Association of the IL-10 polymorphisms and periodontitis: a meta-analysis

Albuquerque, Carlos; Cortinhas, António; Morinha, Francisco; Leitão, José Carlos; Viegas, Carlos; Bastos, Estela

doi:10.1007/s11033-012-1738-1

Cited by 47 publications

(63 citation statements)

References 51 publications

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“…Patient carriers of the IL-6 GG and IL-10 CA or IL-10 AA genotype were considered susceptible to periodontal disease. 23,24 The hypothesis of the present investigation was that individuals susceptible to periodontal disease would demonstrate an increased risk of periodontal disease progression and persisting or recurrent disease activity following treatment as has been determined by previously accepted and validated criteria. 26 We believe this is the first study that investigated this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…30 More specifically, both IL-6 -572 G/C and IL-10 -592 C/A polymorphisms have been associated with an increased protein expression and inflammatory response. 23,31 In the present study, we utilized drops of blood from patients with chronic periodontitis. Genotyping of the polymorphisms in IL-6 (rs1800796) and IL-10 (rs1800872) genes were performed using the real-time polymerase chain reaction technology.…”

Section: Discussionmentioning

confidence: 99%

“…22 A significant increased risk of chronic periodontitis has been associated with IL-6 -572 G/C and IL-10 -592 C/A gene polymorphisms, especially in Caucasian Europeans. 23,24 In periodontal therapy, it is of paramount importance to evaluate the response to active treatment that will detect potential persisting or recurrent disease activity and determine the need for additional therapy. The aim of this study was to examine the effect of interleukin-6 rs1800796 and interleukin-10 rs1800872 gene polymorphisms on the risk of further disease progression and the need for further treatment among adults with chronic periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Chatzopoulos

Doufexi²,

Wolff

et al. 2018

Braz. oral res.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Chatzopoulos

Doufexi²,

Wolff

et al. 2018

Braz. oral res.

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“…A large number of single nucleotide polymorphisms have been identified in the IL-10 gene promoter (17). Of interest are the polymorphisms at -1082 (-1087), -819 (-824) and -592 (-597) (18). However, the presence of an association between IL-10 gene polymorphisms and clinical manifestations of chronic and aggressive periodontitis is controversial.…”

Section: Introductionmentioning

confidence: 99%

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Toker¹,

Görgün²,

Korkmaz³

2017

Cent Eur J Public Health

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SUMMARYObjective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-κB(NF-κB). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-κB1-94ins/del)) and chronic/aggressive periodontitis.Methods: Forty-five patients with chronic periodontitis (CP), 58 patients with aggressive periodontitis (AP) and 38 periodontally healthy subjects were included in this study. Genomic DNA was isolated from whole blood samples. The NF-κB, IL-6, and IL-10 polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: Among subjects for the ins/ins genotypes of NF-κB1 gene, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis group than in healthy controls (p = 0.023). A statistically significant difference in genotyping frequencies between AP group and healthy controls was observed for the IL-6 gene. The AA genotype of IL-10 was overrepresented in CP and AP groups compared to healthy controls (OR = 9.93, 95% CI: 2.11-46.7, OR = 5.7, 95% CI: 1.22-26.89, respectively).Conclusions: Within the limits of this study, it can be concluded that the IL-10 (-597) AA genotype is associated with susceptibility to chronic/ aggressive periodontitis and IL-6 (-174) GG genotypes and G allele seems to be associated with aggressive periodontitis.Clinical relevance: The results of the current study indicate that IL-6 and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-κB1 ins/ins genotypes.

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“…Some studies have illustrated that the IL-10 rs1800896 polymorphism was correlated with enhanced risk of nasopharyngeal carcinoma [25] and gastric cancer [26], diabetic nephropathy [27], and non-Hodgkin's lymphoma [28]. However, non significant correlation between the polymorphism and polycystic ovary syndrome [29], cervical cancer [30], periodontal diseases [31] has been revealed. This means that IL-10 is disease-specific and whether it has an influence on HNC risk remains a confusing due to the inconsistent results of published case-control studies.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

et al. 2017

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BackgroundThe association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation.ResultsSix case-control studies involving 1,781 head and neck cancer patients and 1,978 controls were yielded. The results indicated an association between rs1800896 polymorphism and increased head and neck risk [odds ratio (95%confidence interval) for G vs. A, GA vs. AA, GG vs. AA, GA+GG vs. AA, and GG vs. AA + GA were 1.63 (1.30–2.04), 3.17 (2.11–4.76), 1.63 (1.17–2.26), 1.73 (1.25–2.39), and 2.73 (1.82–4.09), respectively]. The subgroup analyses all obtained similar results with overall populations. The results of clinical stages yielded a non-significant association. No publication bias was detected.Materials and MethodsThe PubMed and Chinese National Knowledge Infrastructure databases were searched up to December 27, 2016. Two authors independently selected studies, extracted and analyzed the data using the RevMan 5 software. Either a fixed effect or a random effect model was used to estimate pooled odds ratio and its 95% confidence intervals.ConclusionsWe concluded that interleukin-10 rs1800896 polymorphism was significantly associated with head and neck cancer risk but not with the clinical stages thereof.

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Association of the IL-10 polymorphisms and periodontitis: a meta-analysis

Cited by 47 publications

References 51 publications

Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

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