Association of the mir-499 polymorphisms with oral cavity and oropharyngeal squamous cell carcinoma in an Iranian population

Akhani, Atefeh; Motaghi, Arash; Sharif, Maryam; Hemati, Simin

doi:10.4103/1735-3327.284734

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2024

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Cited by 3 publications

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Association of genetic variations in microRNAs with susceptibility to head and neck cancer

Abd El-Fadeal,

Toraih,

Fawzy

2024

Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer

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Association of genetic variations in microRNAs with susceptibility to head and neck cancer

Abd El-Fadeal,

Toraih,

Fawzy

2024

Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer

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Non-coding RNA variations in oral cancers: A comprehensive review

Bozgeyik

2023

Gene

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The Role of Single Nucleotide Polymorphisms in MicroRNA Genes in Head and Neck Squamous Cell Carcinomas: Susceptibility and Prognosis

Szmida,

Butkiewicz,

Karpiński

et al. 2024

Genes

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Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. The identification of molecular alterations adding to the individual risk of HNSCC development and progression is one of the most important challenges in studies on cancer genetics. MicroRNAs (miRNAs), which belong to the group of important post-transcriptional regulators of human gene expression, seem to be valuable options for consideration as key modifiers of individual cancer risk, and therefore may be helpful in predicting inter-individual differences in cancer risk, response to treatment and prognosis. Methods: There have not been many studies focused on the relationship between miRNA variants and HNSCC published in PubMed within the last 15 years. We found and analyzed 30 reviews, meta-analyses and research papers and revealed 14 SNPs which have been reported as significant in the context of HNSCC susceptibility and/or prognosis. Results: These 14 SNPs were located in 13 separate miRNAs. Among them, four were the most frequently studied (miRNA-146, -196, -149 and -499) and have been shown to have the greatest impact on the course of HNSCC. However, the presented results have been conflicting. Conclusions: It must be concluded that, despite the years of studies, there are no conclusive reports demonstrating a significant role of SNPs in miRNAs in the context of the susceptibility to HNSCC or its prognosis.

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Association of the mir-499 polymorphisms with oral cavity and oropharyngeal squamous cell carcinoma in an Iranian population

Cited by 3 publications

References 35 publications

Association of genetic variations in microRNAs with susceptibility to head and neck cancer

Association of genetic variations in microRNAs with susceptibility to head and neck cancer

Non-coding RNA variations in oral cancers: A comprehensive review

The Role of Single Nucleotide Polymorphisms in MicroRNA Genes in Head and Neck Squamous Cell Carcinomas: Susceptibility and Prognosis

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