Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review

Xu, Jingyu; Geng, Junze; Zhang, Qiang; Fan, Yihua; Qi, Zijun; Xia, Tian

doi:10.1186/s12957-021-02463-4

Cited by 6 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, patients with CC or CG genotypes of rs2910164 were more susceptible to the other cancers. At the same time, three large meta-analyses found that the CC genotype was associated with a decreased risk of cervical, hepatocellular, and prostate cancer [ 123 , 124 , 125 ].…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

View full text Add to dashboard Cite

There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Data analysis was conducted using STATA 15.1 (StataCorp LP) 23 was used to analyze the data. OR with 95% confidence intervals (95%CI) were utilized for analyzing the risk factors of cardiovascular and cerebrovascular disease subtypes.…”

Section: Methodsmentioning

confidence: 99%

The predictive value of laboratory parameters for no‐reflow phenomenon in patients with ST‐elevation myocardial infarction following primary percutaneous coronary intervention: A meta‐analysis

Wang,

Huang,

Zhou

et al. 2024

Clinical Cardiology

View full text Add to dashboard Cite

To date, the predictive role of laboratory indicators for the phenomenon of no flow is unclear. Hence, our objective was to conduct a meta‐analysis to investigate the association between laboratory parameters and the risk of the no‐reflow phenomenon in patients with ST‐elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI). This, in turn, aims to offer valuable insights for early clinical prediction of no‐reflow. We searched Pubmed, Embase, and Cochrane Library from the establishment of the database to October 2023. We included case‐control or cohort study that patients with STEMI following primary PCI. We excluded repeated publication, research without full text, incomplete information or inability to conduct data extraction and animal experiments, reviews, and systematic reviews. STATA 15.1 was used to analyze the data. The pooled results indicated that elevated white blood cell (WBC) count (odds ratio [OR] = 1.061, 95% confidence interval [CI]: 1.013–1.112), neutrophil count (OR = 1.324, 95% CI: 1.128–1.553), platelet (PLT) (OR = 1.002, 95% CI: 1.000–1.005), blood glucose (OR = 1.005, 95% CI: 1.002–1.009), creatinine (OR = 1.290, 95% CI: 1.070–1.555), total cholesterol (TC) (OR = 1.022, 95% CI: 1.012–1.032), d‐dimer (OR = 1.002, 95% CI: 1.001–1.004), and fibrinogen (OR = 1.010, 95% CI: 1.005–1.015) were significantly associated with increased risk of no‐reflow. However, elevated hemoglobin was significantly associated with decreased risk of no‐reflow. In conclusion, our comprehensive analysis highlights the predictive potential of various parameters in assessing the risk of no‐reflow among STEMI patients undergoing PCI. Specifically, WBC count, neutrophil count, PLT, blood glucose, hemoglobin, creatinine, TC, d‐dimer, and fibrinogen emerged as significant predictors. This refined risk prediction may guide clinical decision‐making, allowing for more targeted and effective preventive measures to mitigate the occurrence of no‐reflow in this patient population.

show abstract

“…STATA 15.1 [14] was used to analyze the data. OR (95% Cl) was used to analyze the risk factors of subtype of cardiovascular and cerebrovascular disease.…”

Section: Methodsmentioning

confidence: 99%

“…[13] 2.5. Data synthesis and statistical analysis STATA 15.1 [14] was used to analyze the data. OR (95% Cl) was used to analyze the risk factors of subtype of cardiovascular and [15] Cohort study Any stroke 7…”

Section: Literature Quality Assessmentmentioning

confidence: 99%

Risk factors of cardiovascular and cerebrovascular diseases in young and middle-aged adults: A meta-analysis

Wu¹,

Xiong²,

Wang³

et al. 2022

Medicine

View full text Add to dashboard Cite

Background: The risk factors for cardiovascular and cerebrovascular diseases in young and middle-aged people have not yet been determined. We conducted a meta-analysis to find the risk factors for cardiovascular and cerebrovascular diseases, in order to provide guidance for the prevention of diseases in the young and middle-aged population. Methods: We searched PubMed, Embase, Cochrane Library from the establishment of the database to Mar 2022. We included case-control or cohort studies reporting risk factors for cardiovascular and cerebrovascular disease in young and middle-aged adults. We excluded repeated publication, research without full text, incomplete information or inability to conduct data extraction and animal experiments, reviews and systematic reviews. STATA 15.1 was used to analyze the data. Results: The pooled results indicated that increased systolic blood pressure was significantly associated with increased risk of any stroke, ischemic stroke and hemorrhagic stroke. Body Mass Index (BMI), current smoking, hypertension, and diabetes were significantly associated with increased risk of any stroke and ischemic stroke. Atrial fibrillation was only significantly associated with increased risk of any stroke. Increased total cholesterol was significantly associated with an increased risk of ischemic stroke, whereas increased triglycerides were significantly associated with a decreased risk of ischemic stroke. In addition, increased hypertension was also significantly associated with an increased risk of acute coronary syndrome. Conclusion: Our pooled results show that BMI, current smoking, atrial fibrillation, hypertension, systolic blood pressure, and total cholesterol can be used as risk factors for cardiovascular and cerebrovascular diseases in young people, while triglycerides can be used as protective factors for cardiovascular and cerebrovascular diseases in young and middle-aged adults.

show abstract

Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review

Cited by 6 publications

References 40 publications

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

The predictive value of laboratory parameters for no‐reflow phenomenon in patients with ST‐elevation myocardial infarction following primary percutaneous coronary intervention: A meta‐analysis

Risk factors of cardiovascular and cerebrovascular diseases in young and middle-aged adults: A meta-analysis

Contact Info

Product

Resources

About