Association of Type 2 Diabetes Mellitus with Central Corneal Thickness and Intraocular Pressure – A Case Control Study

Kalaivani, K.; Mishra, Preeti; Kumar, Samir

doi:10.31782/ijcrr.2020.122218

Cited by 1 publication

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“…1 Diabetes has become a global epidemic problem It was predicted that 451 million diabetics existed in 2017, with this Figure expected to increase to 693 million by 2045. 2 Most patients with type 2 diabetes, even when using anti-diabetic drugs, struggle to maintain sufficient glycemic regulation and develop microvascular and macrovascular diabetic complications. 3,4 Current diabetes therapy has lots of side effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of in vitro Antidiabetic Activity of Novel Pyrrolidine Sulphonamide Derivative

Salve

Jadhav

2021

IJPI

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Background: Diabetes is a long-term illness characterized by high blood sugar levels. It is estimated that by 2045, there will be nearly 693 million diabetic patients worldwide, with half of the population remaining undiagnosed. Metformin, insulin, sulfonylureas, and thiazolidinediones were related to several risk factors, including hypoglycemia, bone fracture, weight gain, cardiovascular, renal, and other complications. In the present study, we have explored the DPP-IV inhibitors as a new class of antidiabetic drugs. Objectives: The goal of DPP-IV inhibitors is to raise levels of incretins (GLP-1 and GIP), which block glucagon release while boosting insulin secretion, slowing stomach emptying, and reducing blood glucose levels. Methods: A series of derivatives substituted on Oxadiazole of sulfonamide pyrrolidine were produced by reacting 1,2,4-oxadiazol and sulfonyl chloride at room temperature in the presence of ethanol and stirring until the reaction was complete. The compounds were characterized using IR, 1 H NMR, C 13 NMR, mass spectroscopy, elemental analysis, and screened for in vitro assay of DPP-IV inhibition. Results and Discussion: The IC 50 was calculated for compounds B-I, B-V, B-VI, B-XI, and B-XIII that inhibited enzymes significantly, IC 50 values ranging from 19.65 ± 2.60 nM to 11.32 ± 1.59 nM, respectively, and Vildagliptin (4.79±1.66 IC 50 nM) was used as a standard. The most active derivative substituted Oxadiazole of pyrrolidine sulfonamide is B-XI (11.32 ± 1.59 IC 50 nM) among all synthesized compounds. Conclusion: B-XI derivative has shown appreciable DPP-IVinhibitory action. The 1,2,4-oxadiazol-3-yl pyrrolidine-1-sulfonamide derivatives have shown anti-diabetic properties.

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