Association of Vulvar Melanoma with Lichen Sclerosus

Hieta, Niina; Kurki, Samu; Rintala, Marjut; Hietanen, Sakari; Orte, Katri

doi:10.2340/00015555-3103

Cited by 21 publications

(45 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The risk factors for developing a vulvar melanoma are poorly understood. The relation with a previous lichen sclerosis lesion has been previously described [ 22 ], but no other risk factors are known. Regarding one of the cases presented in this review, a possible relation with a chronic immunosuppressive treatment could be hypothesized.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Vulvar Melanoma: A Case Series

et al. 2021

View full text Add to dashboard Cite

Vulvar malignant melanoma is the second most common subtype of vulvar cancer, accounting for 5–10% of all vulvar cancers. The prognosis is still very poor, although some advances have been achieved in the last years. One of the most significant changes in its management has been the development of less invasive surgical techniques that diminish the risk of postoperative morbidity and long-lasting sequelae. In this article, we review the surgical management of the pathology, based on the comment of 3 cases with vulvar melanoma treated at our institution.

show abstract

Section: Discussionmentioning

confidence: 99%

Surgical Management of Vulvar Melanoma: A Case Series

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The risk for SCC among patients with LS is increased, with standardized incidence ratio of 33.4 1 , 5 . Also, the risk of vulvar melanoma among patients with LS is 341 times higher than the risk among women without LS 6 . There are anecdotal reports of basal cell carcinoma and Merkel cell carcinoma developing in patients with LS, but the risk for these malignancies has not been shown to be increased 1 , 7 …”

Section: Discussionmentioning

confidence: 99%

Vulvar malignant pleomorphic adenoma in a patient with lichen sclerosus

et al. 2019

View full text Add to dashboard Cite

“…Unlike cutaneous melanomas, VMs are unrelated to chronic sun exposure and damage from ultraviolet light. Chronic dermatoses such as lichen sclerosus have been discussed as potential risk factors based on findings from a populationbased study, but this warrants validation in larger scaled and prospective studies [17,18]. Molecular characterization of VMs may shed more light on the carcinogenesis.…”

Section: Cancerogenesis and Molecular Biology Of Vmmentioning

confidence: 99%

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment

Wohlmuth

Wohlmuth-Wieser

2021

Am J Clin Dermatol

View full text Add to dashboard Cite

Ten percent of all women have pigmented vulvar lesions. Fortunately, most of these are benign but 1% of all melanomas in women affect the vulva. While the mortality rate of cutaneous melanoma has dropped by 7% annually during the last 5 years, the prognosis of vulvar melanoma remains dismal: the 5-year overall survival rate is 47% compared with 92% for cutaneous melanoma. The current evidence suggests that this likely results from a combination of delayed diagnosis and different tumor biology, treatment strategies, and treatment response. Although many landmark trials on checkpoint inhibitors included mucosal and vulvar melanomas, the results were often not reported separately. Post-hoc analyses indicate overall response rates between 19 and 37% for checkpoint inhibitors. A recently published retrospective study on vulvar melanomas suggests an objective response in 33.3% with a similar safety profile to cutaneous melanoma. Tyrosine kinase inhibitors may be considered in recurrent disease if a c-KIT mutation is present. Key PointsCompared with skin melanomas, vulvar melanomas are associated with a poor prognosis resulting from delayed diagnosis and different tumor biology, treatment strategies, and treatment response.Novel treatment modalities include checkpoint inhibitors and targeted therapies and recent evidence shows that these are also effective in vulvar melanomas.Vulvar melanomas have a different tumor biology with frequent c-KIT mutations, which provides an additional therapeutic target in recurrent disease.

show abstract

Association of Vulvar Melanoma with Lichen Sclerosus

Cited by 21 publications

References 11 publications

Surgical Management of Vulvar Melanoma: A Case Series

Surgical Management of Vulvar Melanoma: A Case Series

Vulvar malignant pleomorphic adenoma in a patient with lichen sclerosus

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment

Contact Info

Product

Resources

About