Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women

Costas, Javier; Gratacòs, Mónica; Escaramís, Geòrgia; Martín‐Santos, Rocío; Diego, Yolanda de; Baca‐García, Enrique; Cañellas, Francesca; Estivill, Xavier; Guillamat, Roser; Guitart, Míriam; Gutiérrez-Zotes, Alfonso; García-Esteve, Luisa; Mayoral, Fermín; Moltó, María Dolores; Phillips, C.; Roca, Miquel; Carracedo, Ángel; Vilella, Elisabet; Sanjuán, Julio

doi:10.1016/j.jpsychires.2009.12.012

Cited by 71 publications

(51 citation statements)

References 61 publications

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“…We found a significant decrease of PRKCB1 mRNA expression in SSD compared to the control group. Costas et al (Costas et al, 2010) examined five hundred and eight SNPs in 44 genes, and revealed an association between PRKCB1 and major depression in 1804 post-partum women from Spain: their observations are consistent with our findings. Several pieces of evidence also supported our conclusion.…”

Section: Discussionsupporting

confidence: 91%

Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

Guo¹,

Li²,

Zhang³

et al. 2015

Journal of Psychiatric Research

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Section: Discussionsupporting

confidence: 91%

Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

Guo¹,

Li²,

Zhang³

et al. 2015

Journal of Psychiatric Research

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“…In this sense, it is necessary to carry out comparative research where intergroup differences are assessed among pOCD, npOCD and gynaecological patients without OCD. On the one hand, at the neuroendocrine level, no study has been carried out that monitors and contrasts the levels of female steroids and/or oxytocin (Costas et al, 2010). As for the cognitive behavioural model, there have neither been comparative studies regarding the levels of hyper-responsibility (McGuiness et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Obsessive-compulsive disorder in the perinatal period: Epidemiology, phenomenology, pathogenesis, and treatment. [Trastorno obsesivo-compulsivo durante el período perinatal: epidemiología, fenomenología, etiopatogenia y tratamiento]

et al. 2015

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Título: Trastorno obsesivo-compulsivo durante el período perinatal: epidemiología, fenomenología, etiopatogenia y tratamiento. Resumen: El objetivo de la presente revisión teórica es describir los principales hallazgos e investigaciones sobre el trastorno obsesivo-compulsivo (TOC) durante el período perinatal. Por una parte, los estudios epidemioló-gicos señalan que en esta etapa aumenta el riesgo de debut y/o exacerbación del TOC, especialmente en el puerperio. A nivel fenomenológico, predominan las obsesiones agresivas y de contaminación relacionadas con la figura del feto o neonato. En cuanto a su etiopatogenia, existen evidencias indirectas para postular la participación de variables neuroendocrinas (p.e. esteroides gonadales femeninos y oxitocina) y cognitivo-conductuales (p.e. hiperresponsabilidad, sobreestimación de la amenaza y control mental), siendo necesaria una mayor contrastación empírica de estos correlatos y/o factores de vulnerabilidad específicos. En el ámbito interventivo, se carece de ensayos clínicos aleatorizados con grupo control adaptados a las características idiosincrásicas de este subgrupo de sujetos con TOC. Así mismo, se destaca el papel de la terapia cognitivo-conductual (TCC) en el marco de la prevención primaria selectiva. Palabras clave: Trastorno obsesivo-compulsivo; período perinatal; prevención primaria; terapia cognitivo-conductual; estudio teórico. Abstract:The aim of this review is to describe the main theoretical findings and research conclusions about obsessive-compulsive disorder (OCD) in the perinatal period. On one hand, epidemiological studies show that the risk of OCD onset and/or exacerbation could increase in this period, particularly in the puerperium. Phenomenologically, in this stage aggressive and contamination obsessions are very common and are related to the fetus or newborn. On the other hand, regarding OCD pathogenesis in this period, there is indirect evidence to suggest the participation of neuroendocrine (e.g. female gonadal steroids and oxytocin) and cognitive behavioural variables (e.g. hyper-responsibility, threat overestimation, and mental control). In terms of research, more empirical studies are needed to contrast these specific vulnerability factors. Moreover, no empirically validated psychotherapeutic treatments (controlled trials) adapted to this OCD subgroup were found, although some studies highlight the role of cognitive behavioural therapy (CBT) as an effective intervention in the context of selective primary prevention.

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“…GWA studies are able to perform a wide scanning between different polymorphisms in an effort to identify those that are associated with the outcomes. Of the studies selected in this review, four used this methodology (Costas et al, 2010;El-Ibiary et al, 2013;Mahon et al, 2009;Pinsonneault et al, 2013), all of which assessed depressive states only during the postpartum period. Mahon et al (2009) studied two samples composed of clinical subjects diagnosed with bipolar or depressive disorders.…”

Section: Molecular Genetic Studies Using Other Modern Methodologiesmentioning

confidence: 99%

“…Using the sample from the Spanish study cited previously (Sanjuan et al, 2008), Costas et al (2010) analyzed 508 tagging SNPs that were selected based on linkage disequilibrium (r 2 4 0.8). They found a significant association for haplotypes formed by three SNPs in the protein kinase C (PRKC) gene promoter.…”

Section: Molecular Genetic Studies Using Other Modern Methodologiesmentioning

confidence: 99%

The Influence of genetic factors on peripartum depression: A systematic review

Figueiredo

Parada

Araújo

et al. 2015

Journal of Affective Disorders

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Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women

Cited by 71 publications

References 61 publications

Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

Obsessive-compulsive disorder in the perinatal period: Epidemiology, phenomenology, pathogenesis, and treatment. [Trastorno obsesivo-compulsivo durante el período perinatal: epidemiología, fenomenología, etiopatogenia y tratamiento]

The Influence of genetic factors on peripartum depression: A systematic review

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