Associations between HLA-C alleles and papillary thyroid carcinoma

Haghpanah, Vahid; Khalooghi, Keynoosh; Adabi, Khadijeh; Amiri, Parvin; Tavangar, Seyed Mohammad; Amirzargar, Ali Akbar; Ghaffari, Seyed H.; Yazdani, Nasrin; Nikbin, Behrooz; Larijani, Bagher; Amoli, Mahsa M.

doi:10.3233/cbm-2009-0564

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…Recent studies also have found associations between HLA-C and Graves'disease, with HLA-C * 07 as predisposing and HLA-C * 03 and HLA-C*16 as protective alleles [26]. We have previously reported an association between HLACw*4 and HLACw*15 allele [18] and papillary thyroid carcinoma in our patients. In this study we have found that the Linkage disequilibrium is strong between HLA-DR and HLA-C loci in our population and HLA-DRB1*04 and HLACw15 were predicted to form a haplotype in our population.…”

Section: Discussionsupporting

confidence: 73%

HLA-DR Association in Papillary Thyroid Carcinoma

et al. 2010

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Abstract.Objective: Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-DR and papillary thyroid carcinoma in an Iranian population. Design: HLA-DR antigen frequencies were determined in patients with papillary thyroid carcinoma (N = 70) and non-related healthy controls (N = 180) using PCR -SSP. Main Outcome: We found that HLA-DRB1*04 frequency was significantly higher in our patients compared to the controls [P = 0.02, OR; 1.9, 95% CI (1.04-3.57)]. Conclusions: Our results revealed HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for associations between HLA-DRB1 and differentiated carcinomas in other populations.

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Section: Discussionsupporting

confidence: 73%

HLA-DR Association in Papillary Thyroid Carcinoma

et al. 2010

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“…Several case-control studies have examined the association between -31G/C polymorphism and cancer risk (Srivastava et al, 2012), including nasopharyngeal carcinoma (Yang et al, 2009a), esophaseal cancer (Yang et al, 2009b), gastric cancer (Yang et al, 2009a;Borges et al, 2010), hepatocellular carcinoma (Bayram et al, 2011), pancreatic cancer (Theodoropoulos et al, 2010), and urothelial carcinoma (Wang et al, 2009). Immunohistochemical staining for survivin expression in tissue samples of thyroid carcinoma has shown the increased expression of survivin in thyroid carcinoma (Haghpanah et al, 2009). In a study on 110 patients with oral SCC, survivin expression was observed in 82.7% of patients, and all cases with metastatic carcinoma were positive for survivin expression.…”

Section: Introductionmentioning

confidence: 99%

Survivin Gene Polymorphism Association with Tongue Squamous Cell Carcinoma

Mostaan

Tabari

Amiri

et al. 2013

Genetic Testing and Molecular Biomarkers

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“…Because of its important role in the immune response and high polymorphism, the HLA system is associated with many diseases. Recently, many papers about the association between HLA and many types of tumor have been published, including cervical cancer (Schiff et al, 2005;Madeleine et al, 2008), leukemia (Dorak et al, 2002;Mundhada et al, 2004;Wu et al, 2007;Yari et al, 2008), gastric cancer (Wu et al, 2002;Quintero et al, 2005), ovarian cancer (Kübler et al, 2006), thyroid cancer (Haghpanah et al, 2009), and breast cancer (Cantú de León et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Yang¹,

Wang²,

Shi³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequencebased typing and PCR with sequence-specific primers. We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, and 0.019, respectively, and the odds ratio values were 1. 052, 3.513, 4.047, 3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was lower in the lung carcinoma group than in the normal control group (P = 0.046, odds ratio = 0.168). We concluded that patients with lung

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Associations between HLA-C alleles and papillary thyroid carcinoma

Abstract: Our results revealed certain HLA-C alleles are predisposing factors in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for association between HLA-C alleles and differentiated carcinomas in other populations.

Cited by 13 publications

References 27 publications

HLA-DR Association in Papillary Thyroid Carcinoma

HLA-DR Association in Papillary Thyroid Carcinoma

Survivin Gene Polymorphism Association with Tongue Squamous Cell Carcinoma

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

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