Associations Between Lifestyle Characteristics and the Presence of Nonalcoholic Fatty Liver Disease: A Case–Control Study

Katsagoni, Christina N.; Georgoulis, Michael; Papatheodoridis, George V.; FragopoulouElisabeth,; IoannidouPanagiota,; PapageorgiouMariviki,; Alexopoulou, Alexandra; PapadopoulosNikolaos,; DeutschMelanie,; Kontogianni, Meropi D.

doi:10.1089/met.2016.0105

Cited by 40 publications

(46 citation statements)

References 61 publications

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“…Greek case-control study matched with age, sex, and BMI, 30 but the results showed a tendency of protection with a OR of 0.72 (95% CI: 0.41-1.25). The possible explanation for null association is the small sample size (100 cases and 55 controls) in that study.…”

Section: Discussionmentioning

confidence: 93%

“…Similarly, a study (134 cases and 217 controls) in Greece showed that nut consumption was inversely associated with NAFLD, with OR ranging from 0.92 to 0.98 . However, no association was observed between nut intake and NAFLD in another Greek case‐control study matched with age, sex, and BMI, but the results showed a tendency of protection with a OR of 0.72 (95% CI: 0.41‐1.25). The possible explanation for null association is the small sample size (100 cases and 55 controls) in that study.…”

Section: Discussionmentioning

confidence: 95%

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Association between nut consumption and non‐alcoholic fatty liver disease in adults

Zhang

et al. 2019

Liver International

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Background & Aims Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population. Methods A total of 23 915 participants from Tianjin Chronic Low‐Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD. Results After adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2‐3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers. Conclusions Higher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Association between nut consumption and non‐alcoholic fatty liver disease in adults

Zhang

et al. 2019

Liver International

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“…Lifestyle is an important factor for metabolic syndrome, and it is associated with NAFLD [29]. Further, exercising to lose weight is an indispensable part of lifestyle interventions, and it is proposed as a useful independent item for NAFLD [22].…”

Section: Discussionmentioning

confidence: 99%

The Lifestyle Characteristics in Non-Alcoholic Fatty Liver Disease in the PERSIAN Guilan Cohort Study

Mansour-Ghanaei¹,

Mansour-Ghanaei²,

Naghipour³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide. Since the effect and safety of pharmacotherapy for NAFLD are unknown, the proper management of lifestyle is crucial. AIM: The present study was conducted to determine the status of food, Physical Activity (PA), and sleep in patients with and without NAFLD. METHODS: In this analytical- cross-sectional study, 630 clients with 36-60 years old who referred to the PERSIAN Guilan cohort study were included through simple non-random sampling. The developed questionnaire and lifestyle characteristics, including the status of nutrition, physical activity, and sleep, were completed for all samples. BMI was also calculated by determining weight and height, and fatty liver was confirmed based on abdominal ultrasound. RESULTS: The prevalence of NAFLD in this study was by 43.7% (275 / 630). Smoking, alcohol consumption, BMI, and weight loss over the past six months, regular exercise and exercise intensity, sedentary living, speed of eating, consuming fatty food, red meat, sweets beverages, and use of saturated fatty acid (SFA), and consuming fruits and vegetables were associated with presence of NAFLD (all p < 0.05). However, no significant relationship was observed between the parameters of sleep duration, the interval between dinner and night sleep, consuming breakfast and snack during the day and NAFLD (All p > 0.05). CONCLUSION: The onset and progression of NAFLD are associated with lifestyle. Therefore, dietary therapy solutions, physical activity, and sleep and rest situations should be paid attention for people with or at risk of NAFLD.

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“…Most of the studies have focused on assessing the role of MD, and variants of it, on the prevention and reduction of steatosis, as shown in Table 1. In a case-control study, a Mediterranean dietary and lifestyle pattern was associated to a lower likelihood of having steatosis, independently from body weight and energy intake [85]. The investigators included 100 ultrasound-proven NAFLD patients and 55 healthy controls; dietary habits were assessed through a semi-quantitative food questionnaire.…”

Section: Current Evidence About the Effects Of The Mediterranean Dietmentioning

confidence: 99%

Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered

et al. 2019

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Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is expected to become the leading cause of end-stage liver disease worldwide over the next few decades. In fact, NAFLD encompasses different clinical scenarios, from the simple accumulation of fat (steatosis) to steatohepatitis (NASH), NASH-cirrhosis, and cirrhosis complications. In this context, it is fundamental to pursue strategies aimed at both preventing the disease and reducing the progression of liver fibrosis once liver damage is already initiated. As of today, no pharmacological treatment has been approved for NAFLD/NASH, and the only recommended treatment of proven efficacy are life-style modifications, including diet and physical exercise pointing at weight loss of 5%–7%. Different dietetic approaches have been proposed in this setting, and in this review, we will discuss the evidence regarding the efficacy of the Mediterranean Diet as a treatment for NAFLD. In particular, we will report the effects on liver-related outcomes.

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Associations Between Lifestyle Characteristics and the Presence of Nonalcoholic Fatty Liver Disease: A Case–Control Study

Abstract: Higher PA level and optimal sleep duration are associated with lower likelihood, whereas sweets consumption is associated with higher likelihood of having NAFLD. These associations are independent of body weight status and energy intake.

Cited by 40 publications

References 61 publications

Association between nut consumption and non‐alcoholic fatty liver disease in adults

Association between nut consumption and non‐alcoholic fatty liver disease in adults

The Lifestyle Characteristics in Non-Alcoholic Fatty Liver Disease in the PERSIAN Guilan Cohort Study

Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered

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