Associations between milk protein genetic polymorphisms and milk production traits in Merino sheep breed

Corral, Javier; Padilla, J. A.; Izquierdo, M.

doi:10.1016/j.livsci.2010.01.007

Cited by 35 publications

(24 citation statements)

References 20 publications

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“…The milk composition and protein content differ in different species, and are affected by many factors such as the lactation stage (Maria et al, 2014). The milk proteins in normal white goats and cloned goats were identified to be α-lactalbumin, β-lactoglobulin, α-casein, β-casein, and serum albumin; the protein constitution of goat milk was seen to be in agreement with those reported by previous studies in sheep and goats (Corral et al, 2010;Maria et al, 2014). In this study, two cloned goats with the same genetic background produced milk containing different proteins and different protein contents, despite being phenotypically (gender, coat color, and coat pattern) and genetically (DNA fingerprinting) identical; on the other hand, the phenotypically and genetically dissimilar three normal white goats (controls) produced milk with a similar protein composition and protein content.…”

Section: Discussionsupporting

confidence: 85%

Analysis of polymorphisms in milk proteins from cloned and sexually reproduced goats

Xing¹,

Shao²,

Yy³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study evaluates the relationship between the genotype and milk protein components in goats. Milk samples were collected from cloned goats and normal white goats during different postpartum (or abortion) phases. Two cloned goats, originated from the same somatic line of goat mammary gland epithelial cells, and three sexually reproduced normal white goats with no genetic relationships were used as the control. The goats were phylogenetically analyzed by polymerase chain reaction-restriction fragment length polymorphism. The milk protein components were identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The results indicated that despite the genetic fingerprints being identical, the milk protein composition differed between the two cloned goats. The casein content of cloned goat C-50 was significantly higher than that of cloned goat C-4. Conversely, although the genetic fingerprints of the normal white goats N-1, N-2, and N-3 were not identical, the milk protein profiles did not differ significantly in their milk samples (obtained on postpartum day 15, 20, 25, 30, and 150). These results indicated an association between milk protein phenotypes and genetic polymorphisms, epigenetic regulation, and/or non-chromosomal factors. This study extends 16197©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16196-16203 (2015) Polymorphisms in milk proteins of cloned and normal goats the knowledge of goat milk protein polymorphisms, and provides new strategies for the breeding of high milk-yielding goats.

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Section: Discussionsupporting

confidence: 85%

Analysis of polymorphisms in milk proteins from cloned and sexually reproduced goats

Xing¹,

Shao²,

Yy³

et al. 2015

Genet. Mol. Res.

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“…Some investigations assessed the superiority of the B allele (Rampilli et al, 1997;Bolla et al, 1989). Later, this result was confirmed by Corral et al (2010) in Merino sheep breed.…”

Section: Relationship Between Genetic Variants Of Blg Gene and Milk Pmentioning

confidence: 55%

“…As for milk quality, recently Corral et al (2010) demonstrated that Merino ewes genotyped as AA were those that produced the highest fat and protein percentages. Moreover, heterozygous Serra da Estrela animals presented higher milk fat content than those carrying genotype BB.…”

Section: Relationship Between Genetic Variants Of Blg Gene and Milk Pmentioning

confidence: 99%

β-Lactoglobulin Gene Polymorphisms in Sheep and Effects on Milk Production Traits: A Review

Selvaggi¹

2015

Adv. Anim. Vet. Sci.

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| β-lactoglobulin is the main whey protein of milk from different species. To date, β-lactoglobulin gene (BLG) is one of the most investigated in ruminants including sheep. β-lactoglobulin was the first protein, in which polymorphism was found. Polymorphisms of BLG gene have been detected in several sheep breeds, but studies on the effects of BLG genetic variants on milk production traits and cheese making ability have given conflicting results. Therefore, this paper represents a detailed and updated review on β-lactoglobulin gene polymorphisms in many sheep breeds worldwide. Moreover, the associations among BLG polymorphisms and milk yield and composition as well as milk coagulation properties were reported to offer a complete overview on these topics.

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“…Nevertheless, Baranyi et al (2010) reported a higher frequency of allele A than that of allele B in Racka sheep. Also, (Mohammadi et al 2006, Mele et al 2007, Dario et al 2008, Michalcova & Krupova 2009, Corral et al 2010 reported that allele A is dominant in different sheep breeds. Statistical analysis revealed significant associations between AB genotype of β-LG gene with higher percentages of fat and milk lactose.…”

Section: β-Lactoglobulin Genementioning

confidence: 99%

“…Kawecka & Radko (2011) found no statistical associations between β-LG genotypes and milk yield and composition in Polish Mountain, East Friesian, Polish Merino and Austrian Bergschaf sheep. However, most of the studies have reported significant associations between β-LG polymorphism and milk related traits (Cubric-Curik et al 2002, Corral et al 2010.…”

Section: β-Lactoglobulin Genementioning

confidence: 99%

Effect of β-lactoglobulin and κ-casein genes polymorphism on milk composition in indigenous Zel sheep

et al. 2013

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The effect of β-lactoglobulin (β-LG) and κ-casein (CSN3) genotypes on milk composition were evaluated in Iranian indigenous Zel sheep breed. Genotypes were determined by PCR amplification followed by digestion with RsaI enzyme for exon II of the β-LG gene and SSCP method for exon IV of the CSN3 gene. Polymorphism was detected in all PCR products. β-lactoglobulin showed two alleles and three genotypes and CSN3 gene revealed two conformational patterns, respectively. Results indicated that there were significant associations between AB genotype of β-LG gene with higher fat and lactose percentages and also between K 1 pattern of CSN3 gene with higher lactose percentage. Therefore, it is feasible to improve milk composition in Zel sheep breed using β-LG and CSN3 genes.

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Associations between milk protein genetic polymorphisms and milk production traits in Merino sheep breed

Cited by 35 publications

References 20 publications

Analysis of polymorphisms in milk proteins from cloned and sexually reproduced goats

Analysis of polymorphisms in milk proteins from cloned and sexually reproduced goats

β-Lactoglobulin Gene Polymorphisms in Sheep and Effects on Milk Production Traits: A Review

Effect of β-lactoglobulin and κ-casein genes polymorphism on milk composition in indigenous Zel sheep

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