Associations between TaqI Polymorphisms in Vitamin D Receptor Gene and Type 2 Diabetes Mellitus in Obese Iraqi Population

AL-Darraji, Saifuldeen Z; Al-Azzawie, Hassan F.; AL-Kharsani, Abbas M

doi:10.4172/2155-6156.1000734

J Diabetes Metab

2017

DOI: 10.4172/2155-6156.1000734

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Associations between TaqI Polymorphisms in Vitamin D Receptor Gene and Type 2 Diabetes Mellitus in Obese Iraqi Population

Saifuldeen Z AL-Darraji¹,

Hassan F. Al-Azzawie²,

Abbas M AL-Kharsani³

Abstract: To assess the impact of the association of VDR TaqI polymorphism with T2 diabetic mellitus in Iraqi patients, a total of 200 T2DM diabetic were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of TaqI (rs731236). Results showed that Patients with T allele (TT or Tt) was significantly associated with higher risk of diabetic disease 39%, 78/200, 47.5%, 95/200; P=0.024) compared with patients without T allele (tt; 13.5%, … Show more

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Cited by 3 publications

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“…For any cellular action, activated vitamin D 3 binds to its specific nuclear vitamin D receptor (VDR) in the target tissue 14 . VDR gene is located on 12q13.11 possessing 11 exons with a length of 5.6 kb 15 .…”

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confidence: 99%

Vitamin D and it’s Association with FokI VDR Polymorphism in Patients with Asthma-COPD Overlap

Rosy,

Ali,

Biswas

et al. 2024

J Rang Med Col.

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Background: Asthma-COPD overlap is a new phenotype in respiratory ailments. It has been shown that this group of patients might possess vitamin D3 deficiency. The association of vitamin D receptor (VDR) gene polymorphism with serum vitamin D status in ACO patients has not been investigated yet. Objective: To assess the association of VDR gene polymorphism (FokI) with serum vitamin D status in patients with Asthma-COPD overlap. Methods: This cross-sectional study was carried out in the Department of Physiology of Bangabandhu Sheikh Mujib Medical University, Dhaka, from January 2018 to July 2018 on 23 (twenty-three) patients (aged ≥40 years) with ACO. For comparison, 24 (twenty-four) apparently healthy age, smoking duration and BMI matched subjects were selected. For all participants single nucleotide polymorphism of VDR gene FokI (rs10735810) was done by DNA extraction, polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Vitamin D3 was measured by using automated analyzer: ARCHITECT Plus ci4100. The results were expressed as mean with standard error (mean±SEM) and frequency distribution. The data were statistically analyzed by Graphpad prism (Version 7) using independent sample ‘t’ test, two sample proportion test, Fisher exact test and ANOVA test. In the interpretation of results, ≤0.05 level of probability (p) was accepted as significant. Results: The mean±SEM of serum 25(OH)D were 16.37±0.78 and 18.46±1.01 ng/ml in control and study groups, respectively. The frequency distribution of FokI genotype was 86.95% (FF), 8.69% (Ff), 4.35% (ff) and 91.66% (FF), 4.17% (Ff), 4.17% (ff) in ACO patients and healthy subjects, respectively. When FoKI VDR SNP was analyzed with serum vitamin D status in patients with ACO, statistically no association was seen. Conclusions: FokI VDR SNP is not associated with serum vitamin D status in patients with ACO. J Rang Med Col. March 2024; Vol. 9, No. 1: 22-27

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confidence: 99%

Vitamin D and it’s Association with FokI VDR Polymorphism in Patients with Asthma-COPD Overlap

Rosy,

Ali,

Biswas

et al. 2024

J Rang Med Col.

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Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies

Aravindhan

Almasoody

Selman

et al. 2021

J Diabetes Metab Disord

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Background Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. Here we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms and susceptibility to T2D. Methods All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T2D published up to August 2020 were identified by comprehensive systematic database search in web of science, Scopus, and Medline. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure strength of association. The methodological quality of each study was assessed according to the Newcastle-Ottawa Scale. Subgroup and meta-regression analysis were also performed.Results A total of 47 case-control studies were included in this meta-analysis. The overall population results revealed a significant association between FokI, and BsmI (heterozygote model) polymorphisms and T2D in the overall analysis. However, no association was found with the TaqI and ApaI polymorphisms. Moreover, the pooled results of subgroup analysis by ethnicity suggested significant association between FokI, TaqI, and BsmI polymorphisms and T2D in some subgroups. Meta-regression analyses indicated that none of the publication year, ethnicity, and genotyping method were the source of heterogenicity in all four polymorphisms. Conclusions This meta-analysis suggested a significant association between VDR gene FokI, and BsmI (heterozygote model) polymorphisms and T2D susceptibility in overall population and ethnic-specific analysis.

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Vitamin D Receptor TaqI Gene Polymorphism and Risk of Type 2 Diabetes Mellitus: A Case–Control Study Among Ethiopian Population

Nakachew,

Melake,

Alemu

et al. 2024

Metabolic Syndrome and Related Disorders

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Associations between TaqI Polymorphisms in Vitamin D Receptor Gene and Type 2 Diabetes Mellitus in Obese Iraqi Population

Cited by 3 publications

References 15 publications

Vitamin D and it’s Association with FokI VDR Polymorphism in Patients with Asthma-COPD Overlap

Vitamin D and it’s Association with FokI VDR Polymorphism in Patients with Asthma-COPD Overlap

Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies

Vitamin D Receptor TaqI Gene Polymorphism and Risk of Type 2 Diabetes Mellitus: A Case–Control Study Among Ethiopian Population

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