Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function

Loopstra, Rachel; Liese, Angela D.; Haffner, Steven M.; Wagenknecht, Lynne E.; Hanley, Anthony J.

doi:10.1007/s00125-010-1957-8

Cited by 71 publications

(41 citation statements)

References 24 publications

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“…On the other hand, coffee consumption was associated with a reduced risk, as has previously been observed in other studies [30]. The negative relationship between coffee consumption and the risk of T2DM could also be explained by the positive relationship between caffeine and insulin sensitivity, and between decaffeinated coffee and β cell function [31]. Polyphenols, including coffee and tea polyphenols, seem to inhibit the uptake of intestinal hemo iron [25], thus reducing its adverse effects.…”

Section: Discussionsupporting

confidence: 68%

Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: an observational cohort analysis

et al. 2013

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BackgroundSeveral epidemiological studies have observed an increased risk of type 2 diabetes mellitus (T2DM) among subjects with a higher consumption of red and processed meat. Heme iron intake has been directly associated with a higher risk of T2DM in healthy adult Chinese and U.S populations. The objective of the present study was to evaluate the association between heme iron intake and the incidence of T2DM in a Mediterranean population at high cardiovascular risk.MethodsWe assessed a subset of participants in the PREDIMED trial as an observational cohort, followed up for a maximum of eight years. We initially included 1073 non-diabetic subjects (57.1% women) aged 67.3 ± 6.0 years, at high cardiovascular risk. Diet was assessed at the study baseline using a validated, semi-quantitative food frequency questionnaire.ResultsDuring the follow-up period 131 diabetics were newly diagnosed. The risk of developing T2DM was assessed using baseline heme iron intake and proportional hazard models, first unadjusted, then adjusted for energy, and finally adjusted for dietary, anthropometric, socio-demographic and lifestyle variables. Significant direct associations with the incidence of T2DM were found for heme iron (Hazard Ratio [HR] 1.30, 95% confidence interval [CI], 1.02 to 1.66). Secondarily, we have also observed that coffee (HR:0.93, 95% CI, 0.89 to 0.98) and alcoholic beverages (HR: 1.02, 95% CI, 1.01 to 1.04) were also found to reduce and increase the risk of T2DM, respectively.ConclusionHigh dietary intake of heme iron was associated with an increased risk of developing T2DM in a Mediterranean population at high cardiovascular risk.Trial registrationIdentifier: ISRCTN35739639.

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Section: Discussionsupporting

confidence: 68%

Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: an observational cohort analysis

et al. 2013

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“…For example, a single serving of coffee considerably heightens the postprandial glycemic response in healthy overweight men [42], which can support a potential mechanism explanation for the effects of instant coffee. Furthermore, caffeine consumption in some levels may result in improved insulin sensitivity, which can play an important role in energy regulation and expenditure [43], and obesity is always associated with insulin resistance and type 2 diabetes [44]. Meanwhile, late chronotype may aggravate the chance to consume caffeinated drinks.…”

Section: Discussionmentioning

confidence: 99%

Caffeinated Drinks Intake, Late Chronotype, and Increased Body Mass Index among Medical Students in Chongqing, China: A Multiple Mediation Model

Zhang

Xiong

Dong

et al. 2018

IJERPH

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Background: This paper investigates the problems regarding caffeinated drinks intake, late chronotype, and increased body mass index (BMI) among medical students at a Chinese university. Methods: This cross-sectional study was conducted in 2018 with 616 medical students from Chongqing Medical University in Chongqing, China, whose information were collected by a self-reported questionnaire that included four sections: Demographic characteristics; Caffeinated drinks intake and physical state; Morningness-Eveningness Questionnaire; Depression Anxiety Stress Scale 21. Multiple mediation analyses were conducted to test the impact of late chronotype on increased BMI through caffeinated drinks consumption through two models. Results: The significantly mediated effect of caffeinated drinks consumption was revealed (estimate: −0.01, SE = 0.01, 95% CI [−0.02, −0.01]), and which played a positive role in linking late chronotype (B = −0.01, SE = 0.01, p < 0.001) and increased BMI (B = 1.37, SE = 0.21, p < 0.01), but their significant association did not be found in reversed model. In addition, physical activity and inactivity times demonstrated significant indirect effects in the two models. Conclusions: Interventions should focus on reducing caffeinated drinks intake and sedentary behavior time, enhancing physical activity among medical students.

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“…Type 2 diabetes is a complex disease caused by the combination of b-cell dysfunction and insulin resistance. Recently, it was reported that the intake of caffeinated coffee, but not of decaffeinated coffee, was positively related to insulin sensitivity in humans (3). However, the underlying mechanism by which coffee suppresses the development of type 2 diabetes remained unclear.…”

mentioning

confidence: 99%

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Kobayashi

Matsuda

Iwai

et al. 2012

J Nutr Sci Vitaminol

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Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function

Cited by 71 publications

References 24 publications

Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: an observational cohort analysis

Heme iron intake and risk of new-onset diabetes in a Mediterranean population at high risk of cardiovascular disease: an observational cohort analysis

Caffeinated Drinks Intake, Late Chronotype, and Increased Body Mass Index among Medical Students in Chongqing, China: A Multiple Mediation Model

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

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