Associations between the Prenatal Diet and Neonatal Outcomes—A Secondary Analysis of the Cluster-Randomised GeliS Trial

Günther, Julia; Hoffmann, Julia; Spies, Monika; Meyer, Dorothy; Kunath, Julia; Stecher, Lynne; Rosenfeld, Eva; Kick, Luzia; Rauh, Kathrin; Hauner, Hans

doi:10.3390/nu11081889

Cited by 25 publications

(35 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As noted by others [40], we did not include dietary intake as a covariate. Previously, we reported small effects of the maternal diet on neonatal weight-related parameters [51], and are aware that maternal dietary behavior might have biased the present results. Further potential confounders such as the maternal employment, living circumstances, or other lifestyle factors (smoking, drinking) might have influenced the maternal PA level, but were not considered in the present analyses.…”

Section: Discussionmentioning

confidence: 89%

Associations between Prenatal Physical Activity and Neonatal and Obstetric Outcomes—A Secondary Analysis of the Cluster-Randomized GeliS Trial

Hoffmann

Günther

Geyer

et al. 2019

JCM

View full text Add to dashboard Cite

Prenatal physical activity (PA) was discussed to decrease the incidence of obstetric and neonatal complications. In this secondary cohort analysis of the cluster-randomized GeliS (“healthy living in pregnancy”) trial, associations between prenatal PA and such outcomes were investigated. PA behavior was assessed twice, before or during the 12th week (baseline, T0) and after the 29th week of gestation (T1), using the self-reported Pregnancy Physical Activity Questionnaire. Obstetric and neonatal data were collected in the routine care setting. Data were available for 87.2% (n = 1994/2286) of participants. Significant differences between the offspring of women who adhered to PA recommendations at T1 and offspring of inactive women were found in birth weight (p = 0.030) but not in other anthropometric parameters. Sedentary behavior was inversely associated with birth weight at T1 (p = 0.026) and, at both time points, with an increase in the odds of low birth weight (T0: p = 0.004, T1: p = 0.005). Light-intensity PA at T0 marginally increased the odds of caesarean section (p = 0.032), but neither moderate-intensity nor vigorous-intensity activity modified the risk for caesarean delivery at any time point. The present analyses demonstrated associations between prenatal PA and some neonatal and obstetric outcomes.

show abstract

Section: Discussionmentioning

confidence: 89%

Associations between Prenatal Physical Activity and Neonatal and Obstetric Outcomes—A Secondary Analysis of the Cluster-Randomized GeliS Trial

Hoffmann

Günther

Geyer

et al. 2019

JCM

View full text Add to dashboard Cite

show abstract

“…19 Gunther et al evaluated FFQ data at the 12th and 29th weeks of gestation in the clusterrandomised GeliS Trial of 2286 pregnant women. 5 They determined that consumption of vegetables and good dietary quality, as measured by HEI, were positively associated with birth weight. The HEI was calculated from the FFQ data as the average of scores of 14 food groups and their adherence to recommendations from the German Nutrition Society for a healthy diet where 0 indicated no adherence and 100 indicated high adherence to the Table 4 Adjusted analysis for the model of birth weight, adjusted for exposure of PFOS, nutrition as measured by MNI and covariates, with an indicator for low and high fish consumption defined by an indicator variable (see figure 2; with cut-off at 0.35 times/week).…”

Section: Discussionmentioning

confidence: 99%

“…For example, prenatal consumption of vegetables has been shown to have beneficial effects on birth weight. 5 Adequate prenatal concentrations of vitamins, minerals, protein and essential fatty acids have been shown to have beneficial effects on birth weight and the developing brain, while deficiencies of these nutrients can have the opposite effect. 2 6 However, the complexity of overall nutritiousness during pregnancy—as measured by an index reflecting adherence to the dietary recommendations—has not been used to evaluate pregnancy outcomes and neurodevelopment.…”

Section: Introductionmentioning

confidence: 99%

Contrasting prenatal nutrition and environmental exposures in association with birth weight and cognitive function in children at 7 years

Gennings

Wolk

Håkansson

et al. 2020

BMJNPH

View full text Add to dashboard Cite

BackgroundGood nutrition is essential for individual health, a notion that is particularly true during pregnancy. We have used a nutrition index that measures the adequacy of one’s diet relative to the unique nutritional needs of individuals due to, for example, their activity level, dietary restrictions, lifestyle and body size. The use of this personalised metric of dietary nutritiousness in the analysis of prenatal environmental exposures and developmental outcomes permits testing for potential mitigating effects of good nutrition. We also provide an analysis strategy for investigating the balance in beneficial food sources which are also the source of environmental toxicants.MethodsA holistic measure of nutrition, My Nutrition Index (MNI), measures the nutrient quality (ie, ‘nutritiousness’) of a specified daily diet. MNI is calculated based on quantification of dozens of macronutrients and micronutrients that are specific to an individual’s nutritional needs by incorporating dietary restrictions, subject characteristics, activity level and health behaviours. The Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy Study is a Swedish pregnancy cohort, with prenatal endocrine disrupting chemicals (EDCs) exposure and dietary data available. This makes it possible to test for the potential mitigating effects of good nutrition on health and development effects in offspring from EDCs.ResultsUsing prenatal Food Frequency Questionnaire data to construct an individual’s MNI, the index was significantly and positively associated with important metabolic outcome (as measured by birth weight) and cognitive function at age 7 years (as measured by WISC IQ) in children when adjusted for covariates and prenatal concentrations of an EDC. In a stratified analysis of ‘low’ and ‘high’ fish consumption, a potential source of perfluoro-octanesulfonic acid (PFOS), the association between PFOS and birth weight was diminished in the high consumption group compared with the low consumption group.ConclusionsThus, MNI is evidently a metric of the general nutritiousness of daily diets and is useful in environmental health studies in representing the impact of good nutrition, even during pregnancy.

show abstract

“…9,21 Primary and some secondary outcomes have been published recently. [18][19][20][22][23][24] Details on the study design and setting, and clusterrandomisation, have been described in the study protocol. 21 In brief, the randomisation resulted in one control (CG) area and one intervention (IG) area for each study region.…”

Section: The Gelis Study: Design and Settingmentioning

confidence: 99%

Infant growth during the first year of life following a pregnancy lifestyle intervention in routine care—Findings from the cluster‐randomisedGeliStrial

et al. 2020

View full text Add to dashboard Cite

SummaryBackgroundLifestyle interventions in pregnancy may influence postpartum development and obesity risk in offspring. The impact of lifestyle interventions as health system‐based approaches is unclear.ObjectiveTo evaluate the effect of an antenatal lifestyle intervention conducted as public health approach on infant development and feeding practices.MethodsWe followed offspring born to women participating in the cluster‐randomised GeliS trial who received usual care (CG) or repeated lifestyle counselling (IG). We collected data on offspring development and complementary feeding until the 12thmonth postpartum.ResultsOf the 1998 mother‐child pairs, 1783 completed the follow‐up. Mean infant weight at 12 months was comparable between groups (IG: 9497.9 ± 1137.0 g; CG: 9433.4 ± 1055.2 g;P= .177). There was no significant evidence of differences in sex‐ and age‐adjusted z‐scores or in the odds of offspring being overweight. More infants in the IG received whole‐grain products compared to the CG (95.6%vs. 90.8%;P= .003). Despite small differences in the timing of introducing solid foods, there were no further significant differences in the pattern of complementary feeding.ConclusionsThe antenatal lifestyle intervention embedded in routine care did not substantially influence infant anthropometrics and is thus unlikely to impact future development.

show abstract

Associations between the Prenatal Diet and Neonatal Outcomes—A Secondary Analysis of the Cluster-Randomised GeliS Trial

Cited by 25 publications

References 37 publications

Associations between Prenatal Physical Activity and Neonatal and Obstetric Outcomes—A Secondary Analysis of the Cluster-Randomized GeliS Trial

Associations between Prenatal Physical Activity and Neonatal and Obstetric Outcomes—A Secondary Analysis of the Cluster-Randomized GeliS Trial

Contrasting prenatal nutrition and environmental exposures in association with birth weight and cognitive function in children at 7 years

Infant growth during the first year of life following a pregnancy lifestyle intervention in routine care—Findings from the cluster‐randomisedGeliStrial

Contact Info

Product

Resources

About