Associations between tinnitus and glaucoma suggest a common mechanism: A clinical and population-based study

Loiselle, Allison R.; Neustaeter, Anna; Kleine, Emile de; Dijk, Pim van; Jansonius, Nomdo M.

doi:10.1016/j.heares.2019.107862

Cited by 8 publications

(11 citation statements)

References 39 publications

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“…61 A recently published clinic-based, cross-sectional questionnaire study and a population-based, a cross-sectional study showed that patients with glaucoma are more likely to have tinnitus. 62 Many drugs are linked to tinnitus, 63 with salicylate-the active component of the nonsteroidal anti-inflammatory drug aspirin-being one of the most-well-known drugs. High doses of aspirin can cause temporary hearing loss and reversible tinnitus by directly affecting cochlear function.…”

Section: Risk Factorsmentioning

confidence: 99%

Tinnitus Update

Han¹,

Lee

Ryu

et al. 2021

J Clin Neurol

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This article provides an update on tinnitus for audiologists and other clinicians who provide tinnitus-specific services. Tinnitus can be attributable to hearing loss, somatosensory system dysfunction, or auditory cortex dysfunction, with hearing loss being the most common cause and serious underlying pathologies being rare. Hearing loss does not always lead to tinnitus, and patients with tinnitus do not always suffer from hearing loss. The first scenario is explained by a so-called inhibitory gating mechanism, whereas the second assumes that all tinnitus sufferers have some degree of hearing impairment, which might not be detected in standard audiological examinations. The treatments should aim at symptomatic relief and management of associated distress. Current treatment options include pharmacotherapy, education, counseling, cognitive behavioral therapy, and sound therapy.

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Section: Risk Factorsmentioning

confidence: 99%

Tinnitus Update

Han¹,

Lee

Ryu

et al. 2021

J Clin Neurol

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“…Literature suggests a relationship between glaucoma and tinnitus, with glaucoma patients having 19% increased odds for tinnitus than in patients without it [ 46 ]. The mechanism linking these disorders is ambiguous, but vascular dysregulation may play a significant role in causing both disorders.…”

Section: Pathophysiologymentioning

confidence: 99%

“…The mechanism linking these disorders is ambiguous, but vascular dysregulation may play a significant role in causing both disorders. Nitric oxide (NO) production inhibition is a potential mechanism [ 46 ]. NO is a regulator of intraocular pressure (IOP), thus linking defects in the nitric oxide guanylate cyclase (NO-GC) pathway with glaucoma [ 47 ].…”

Section: Pathophysiologymentioning

confidence: 99%

SARS-CoV-2 vaccine-associated-tinnitus: A review

Ahmed

Waseem

Shaikh

et al. 2022

Annals of Medicine &Amp; Surgery

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The global vaccination drive against severe acute respiratory syndrome coronavirus-2 is being pursued at a historic pace. Unexpected adverse effects have been reported following vaccination, including thrombotic thrombocytopenia, myocarditis, amongst others. More recently, some cases of tinnitus are reported post-vaccination. According to the Vaccine Adverse Events Reporting System (VAERS), 12,247 cases of coronavirus post-vaccination tinnitus have been reported till 14 th September 2021. To the best of our knowledge, this is the first review evaluating any otologic manifestation following vaccine administration and aims to evaluate the potential pathophysiology, clinical approach, and treatment. Although the incidence is infrequent, there is a need to understand the precise mechanisms and treatment for vaccine-associated-tinnitus.

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“…Although corresponding pathomechanisms are still under-investigated, the evident relationship between vascular dysregulation and tinnitus is the reduced bioavailability of nitric oxide (NO) in vasospastic individuals. NO is reduced in the jugular vein of individuals with tinnitus, resulting in disruption of microcirculation in the ear [89].…”

Section: High Altitude Sickness and Tinnitus Are Attributable To Distmentioning

confidence: 99%

Voice perturbations under the stress overload in young individuals: phenotyping and suboptimal health as predictors for cascading pathologies

et al. 2020

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Verbal communication is one of the most sophisticated human motor skills reflecting both—the mental and physical health of an individual. Voice parameters and quality changes are usually secondary towards functional and/or structural laryngological alterations under specific systemic processes, syndrome and pathologies. These include but are not restricted to dry mouth and Sicca syndromes, body dehydration, hormonal alterations linked to pubertal, menopausal, and andropausal status, respiratory disorders, gastrointestinal reflux, autoimmune diseases, endocrinologic disorders, underweight versus overweight and obesity, and diabetes mellitus. On the other hand, it is well-established that stress overload is a significant risk factor of cascading pathologies, including but not restricted to neurodegenerative and psychiatric disorders, diabetes mellitus, cardiovascular disease, stroke, and cancers. Our current study revealed voice perturbations under the stress overload as a potentially useful biomarker to identify individuals in suboptimal health conditions who might be strongly predisposed to associated pathologies. Contextually, extended surveys applied in the population might be useful to identify, for example, persons at high risk for respiratory complications under pandemic conditions such as COVID-19. Symptoms of dry mouth syndrome, disturbed microcirculation, altered sense regulation, shifted circadian rhythm, and low BMI were positively associated with voice perturbations under the stress overload. Their functional interrelationships and relevance for cascading associated pathologies are presented in the article. Automated analysis of voice recordings via artificial intelligence (AI) has a potential to derive digital biomarkers. Further, predictive machine learning models should be developed that allows for detecting a suboptimal health condition based on voice recordings, ideally in an automated manner using derived digital biomarkers. Follow-up stratification and monitoring of individuals in suboptimal health conditions are recommended using disease-specific cell-free nucleic acids (ccfDNA, ctDNA, mtDNA, miRNA) combined with metabolic patterns detected in body fluids. Application of the cost-effective targeted prevention within the phase of reversible health damage is recommended based on the individualised patient profiling.

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Associations between tinnitus and glaucoma suggest a common mechanism: A clinical and population-based study

Cited by 8 publications

References 39 publications

Tinnitus Update

Tinnitus Update

SARS-CoV-2 vaccine-associated-tinnitus: A review

Voice perturbations under the stress overload in young individuals: phenotyping and suboptimal health as predictors for cascading pathologies

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