Associations between urinary organophosphate pesticide metabolite levels and reproductive parameters in men from an infertility clinic

Melgarejo, María; Mendiola, Jaime; Koch, Holger M.; Moñino-García, Miriam; Noguera-Velasco, José Antonio; Torres-Cantero, Alberto M.

doi:10.1016/j.envres.2015.01.004

Cited by 65 publications

(52 citation statements)

References 53 publications

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“…This list reflects the paucity of studies with OPCs. Asymptomatic low-level exposure to OPCs has been reported to cause various health effects including cardiac lesions (8,20,21). Different individual toxicokinetics of OPCs necessitates investigating the effect on the heart under normal and diabetic conditions (22).…”

Section: Discussionmentioning

confidence: 99%

Terbufos-sulfone exacerbates cardiac lesions in diabetic rats: a sub-acute toxicity study

Nurulain

Shafiullah

Yasin

et al. 2016

Archives of Industrial Hygiene and Toxicology

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Organophosphorus compounds (OPCs) have a wide range of applications, from agriculture to warfare. Exposure to these brings forward a varied kind of health issues globally. Terbufos is one of the leading OPCs used worldwide. The present study investigates the cardiac effect of no observable dose of a metabolite of terbufos, terbufos-sulfone (TS), under nondiabetic and streptozotocin-induced diabetic condition. One hundred nanomoles per rat (1/20 of LD 50 ) was administered intraperitoneally to adult male Wister rats daily for fifteen days. The left ventricle was collected for ultrastructural changes by transmission electron microscopy. The blood samples were collected for biochemical tests including RBC acetylcholinesterase, creatinine kinase (CK), lactate dehydrogenase (LDH), cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides, ALT, AST, and GGT. The study revealed about 10 % inhibition of RBCAChE in two weeks of TS treatment in non-diabetic rats whereas RBC-AChE activity was significantly decreased in diabetic TS treated rats. CK, LDH, and triglycerides were significantly higher in diabetic TS treated rats. Electron microscopy of the heart showed derangement and lesions of the mitochondria of cardiomyocytes in the TS treated groups. The present study concludes that a non-lethal dose of TS causes cardiac lesions which exacerbate under diabetic condition. Biochemical tests confirmed the ultrastructural changes. It is concluded that a non-lethal dose of TS may be a risk factor for a cardiovascular disease, which may be fatal under diabetic condition.

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Section: Discussionmentioning

confidence: 99%

Terbufos-sulfone exacerbates cardiac lesions in diabetic rats: a sub-acute toxicity study

Nurulain

Shafiullah

Yasin

et al. 2016

Archives of Industrial Hygiene and Toxicology

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“…In the last two decade, global consumption of OPs has risen steadily, from 102 kilo-tons in 1991 to 320 kilo-tons in 2013, of which China consumed a quarter of the chemicals [3][4][5]. Concerns about human exposure to OPs are due to the fact that some OPs have shown various toxicities to biota including humans [6]. A brief summary of published data on health effects of OPs has been provided in the supporting information (Table S1).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of triphenylphosphine oxide and other organophosphorus compounds in indoor air and settled dust of an institute building

Faiz

Wei

Feng

et al. 2016

Building and Environment

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Please cite this article as: Faiz Y, Zhao W, Feng J, Sun C, He H, Zhu J, Occurrence of triphenylphosphine oxide and other organophosphorus compounds in indoor air and settled dust of an institute building, Building and Environment (2016), AbstractIndoor environments contain a wide range of synthetic products that emit a variety of semi-volatile organic compounds (SVOCs). Among these SVOCs, organophosphorus compounds (OPs) are ubiquitous in indoor environments with relatively high concentrations.This study investigated the occurrence of seven OPs including triphenylphosphine oxide (TPPO) in three different types of indoor spaces (offices, conference halls and laboratories) of an institute building. A total of 39 airborne particulate matter (PM 10 ) and ten settled dust samples were analyzed. Among the seven target OPs, tri(2-chloroethyl) phosphate (TCEP), tri(chloropropyl) phosphate (TCPP) and TPPO were the major ones found in these samples.TPPO was for the first time identified in indoor environments with levels up to 94 ng/m 3 in indoor air and 1.1 µg/g in the indoor settled dust. Positive identity of TPPO in the samples was confirmed by comparisons of the mass spectrum of TPPO peak with that of TPPO standard and same GC retention time of TPPO from samples and from the standard. Compositions of OPs in these samples revealed different sources of OPs present in the indoorspaces. An equilibrium model was used to predict OPs in settled indoor dust from their corresponding levels found in indoor airborne particulate matters. There was a statistically significant correlation between predicted and measured OPs in settled dust in all three types of indoor spaces. The difference between measured and model predicted OP levels in settled dust was in the general range of predictions reported for indoor air SVOCs.

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“…These DAP metabolites are: dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP), dimethyl dithiophosphate (DMDTP), diethyl phosphate (DEP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP). Though these metabolites are not pesticide specific 12 , they have been used as biomarkers of OP exposure in occupational and environmental studies 13 , providing information on recent pesticide exposure (1–3 days) or possibly longer-term exposure (3 months) 14 .…”

Section: Introductionmentioning

confidence: 99%

Exploring Associations Between Postural Balance and Levels of Urinary Organophosphorus Pesticide Metabolites

Kim

Nussbaum²,

Laurienti

et al. 2018

Journal of Occupational &Amp; Environmental Medicine

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Objective Apply a data-driven approach to explore associations between postural balance and pesticide exposure among Latino farmworkers and non-farmworkers. Methods Lasso-regularized, generalized linear models were used to examine associations between postural control measures in four experimental conditions (2 visual × 2 cognitive difficulty) and dialkylphosphate (DAP) urinary metabolite levels. Results Obtained models generally performed poorly at explaining postural control measures. However, when both visual and cognitive conditions were altered – the most challenging balance condition – models for some postural balance measures contained several DAP metabolites and had relatively better fits. Conclusions The current results were equivocal regarding associations between postural control measures and DAP metabolite concentrations. However, farmworker status appears to be an important variable in understanding this association. Future work should use a posturally- and cognitively-challenging test condition to reveal any potential associations.

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Associations between urinary organophosphate pesticide metabolite levels and reproductive parameters in men from an infertility clinic

Cited by 65 publications

References 53 publications

Terbufos-sulfone exacerbates cardiac lesions in diabetic rats: a sub-acute toxicity study

Terbufos-sulfone exacerbates cardiac lesions in diabetic rats: a sub-acute toxicity study

Occurrence of triphenylphosphine oxide and other organophosphorus compounds in indoor air and settled dust of an institute building

Exploring Associations Between Postural Balance and Levels of Urinary Organophosphorus Pesticide Metabolites

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