Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients

Pertiwi, Kamalita; Küpers, Leanne K.; Wanders, Anne J.; Goede, Janette de; Zock, P.L.; Geleijnse, Johanna M.

doi:10.1186/s12986-019-0407-y

Cited by 15 publications

(12 citation statements)

References 26 publications

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“…Dairy intake, particularly low-fat dairy, has been associated with a better kidney function, possibly due to blood pressure lowering minerals such as calcium, potassium and magnesium [49,50]. Plasma OCFAs have been identified as biomarkers of dairy intake, also in the present cohort [51], but we found no association of OCFAs with kidney function decline. Plasma C14:0 has also been proposed as a dairy biomarker [52], although it may also reflect saturated fat intake from coconut or palm oil [53].…”

Section: Discussioncontrasting

confidence: 69%

Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort

Westing

Eckl

Küpers

et al. 2021

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Age-related kidney function decline is accelerated in patients with coronary heart disease (CHD). CHD and chronic kidney disease may share common etiologies. We examined plasma fatty acids (FAs) as novel biomarkers of kidney function decline after myocardial infarction (MI). Methods and results: The analysis included 2329 Dutch posteMI patients aged 60-80y (Alpha Omega Cohort) most receiving state-of-the-art medications. Plasma FAs (% total FAs) in cholesteryl esters were assessed at baseline (2002e2006), and w40 months change in creatininecystatin C based glomerular filtration rate was estimated (eGFR, in ml/min per 1.73 m 2 ). Beta coefficients for annual eGFR change in relation to plasma linoleic acid (LA; 50.1% of total FAs in CE), omega-3 FAs (EPA þ DHA; 1.7%), odd-chain FAs (C15:0 and C17:0; 0.2%), and C14:0 (0.7%) were obtained from linear regression analyses adjusted for age, sex, smoking, and alcohol intake. Mean baseline eGFR AESD was 78.5 AE 18.7, which declined by 4.7 AE 13.1 during follow-up, or 1.4 AE 3.9 per year. The annual decline in eGFR was less in patients with higher plasma LA (adjusted beta: 0.40 for LA >47 vs 47%, 95% CI: 0.01; 0.78; p Z 0.046). Associations of plasma LA with annual eGFR decline were stronger in 437 patients with diabetes (1.21, 0.24; 2.19) and in 402 patients with CKD (eGFR<60; 0.90, À0.09; 1.89). Weaker, non-significant associations with kidney function decline were observed for the other plasma FAs. Conclusion: Higher plasma LA may be a good predictor of less kidney function decline after MI, particularly in patients with diabetes.The Alpha Omega Cohort is registered with clinicaltrials.gov, NCT03192410.

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Section: Discussioncontrasting

confidence: 69%

Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort

Westing

Eckl

Küpers

et al. 2021

Nutrition, Metabolism and Cardiovascular Diseases

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“…In a recent study from Pertiwi et al using a cohort of post-myocardial infarction patients, it was suggested that the associated health benefits attributed to C17:0 may be partially explained by dietary fiber intake. 63 Human studies showing that a strong association between BCAA and OCFA is lost in disease states suggest that more research is required on the metabolite sources of OCFA and their roles in modulating energy homeostasis. This is important to further understand which metabolites lead to these beneficial health outcomes reported to be associated with OCFA in other studies.…”

Section: Discussionmentioning

confidence: 99%

The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism

et al. 2020

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Dairy intake, as a source of branched-chain amino acids (BCAA), has been linked to a lower incidence of type-2-diabetes and increased circulating odd-chain fatty acids (OCFA). To understand this connection, we aimed to investigate differences in BCAA metabolism of leucine and valine, a possible source of OCFA, and their role in hepatic metabolism. Male mice were fed a high-fat diet supplemented with leucine and valine for 1 week and phenotypically characterized with a focus on lipid metabolism. Mouse primary hepatocytes were treated with the BCAA or a Pparα activator WY-14643 to systematically examine direct hepatic effects and their mechanisms. Here, we show that only valine supplementation was able to increase hepatic and circulating OCFA levels via two pathways; a PPARα-dependent induction of α-oxidation and an increased supply of propionyl-CoA for de novo lipogenesis.Meanwhile, we were able to confirm leucine-mediated effects on the inhibition of food intake and transport of fatty acids, as well as induction of S6 ribosomal protein phosphorylation. Taken together, these data illustrate differential roles of the BCAA in lipid metabolism and provide preliminary evidence that exclusively valine contributes to the endogenous formation of OCFA which is important for a better understanding of these metabolites in metabolic health.

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“…Plasma C17:0 levels increase after dietary supplementation with inulin and propionate [8], and endogenous production (through elongation of propionyl-CoA or a-oxidation of C18:0) seems an important source of circulating C17:0 [50]. Indeed, in some studies, C17:0 in phospholipids was more strongly correlated with fiber intake than with dairy intake [51,52], while C15:0 had stronger correlations with dairy intake [7]. In our data, however, lipids with C17:0 correlated with dietary variables similarly as the lipids with C15:0.…”

Section: Food Determinants Of Ocfa-containing Lipidsmentioning

confidence: 99%

Association of the odd-chain fatty acid content in lipid groups with type 2 diabetes risk: A targeted analysis of lipidomics data in the EPIC-Potsdam cohort

et al. 2021

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Background: Plasma odd-chain saturated fatty acids (OCFA) are inversely associated with type 2 diabetes (T2D) risk and may serve as biomarkers for dairy fat intake. Their distribution across different lipid classes and consequences for diabetes risk remain unknown. Aim: To investigate the prospective associations of OCFA-containing lipid species with T2D risk and their dietary determinants. Methods: Within the European Prospective Investigation into Cancer and NutritionePotsdam study (n ¼ 27,548), we applied a nested case-cohort design (subcohort: n ¼ 1248; T2D cases: n ¼ 820; median follow-up 6.5 years). OCFA-containing lipids included triacylglycerols, free fatty acids (FFA), cholesteryl esters (CE), phosphatidylcholines, phosphatidylethanolamines, lysophosphatidylcholines, lysophosphatidylethanolamines, monoacylglycerols, and diacylglycerols. We estimated lipid class-specific associations between OCFA-containing lipids and T2D in sex-stratified Cox proportional-hazards models. We investigated correlations between lipids and dietary intakes derived from food-frequency questionnaires. Results: We observed heterogeneous integration of OCFA in different lipid classes: triacylglycerols, FFA, CE, and phosphatidylcholines contributed most to the total OCFA-plasma abundance. The relative concentration of OCFA was particularly high in monoacylglycerols, and the contribution of C15:0 versus C17:0 to the total OCFA-abundance differed across lipid classes. In women, several OCFA-containing phospholipids were inversely associated with T2D risk [phosphatidylcholine(C15:0), HR Q5 vs Q1: 0.56, 95% CI 0.32e0.97; phosphatidylcholine(C17:0), HR per SD: 0.59, 95% CI 0.48e0.71; lysophosphatidylcholine(C17:0), HR Q5 vs Q1: 0.42, 95% CI 0.23e0.76]. In men, we did not detect statistically significant inverse associations in phospholipids, and lysophosphatidylcholine(C15:0) was associated with higher T2D risk (HR Q1 vs. Q5: 1.96, 95% CI 1.06e3.63). Besides, CE(C17:0), monoacylglycerols(C15:0), and diacylglycerols(C15:0) were inversely associated with T2D risk; FFA(C17:0) was positively associated with T2D risk in women. Consumption of fat-rich dairy and fiber-rich foods were positively and red meat inversely correlated to OCFA-containing lipid plasma levels. Conclusions: OCFA-containing lipids are linked to T2D risk in a lipid class and sex-specific manner, and they are correlated with several foods.

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Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients

Cited by 15 publications

References 26 publications

Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort

Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort

The branched‐chain amino acids valine and leucine have differential effects on hepatic lipid metabolism

Association of the odd-chain fatty acid content in lipid groups with type 2 diabetes risk: A targeted analysis of lipidomics data in the EPIC-Potsdam cohort

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