Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network

Moira, Angela Pinot de; Strandberg‐Larsen, Katrine; Bishop, Tom; Pedersen, Marie; Avraam, Demetris; Cadman, Tim; Calas, Lucinda; Casas, Maribel; Lauzon-Guillain, Blandine de; Elhakeem, Ahmed; Estarlich, Marisa; Foong, Rachel E.; Haakma, Sido; Harris, Jennifer R.; Huang, Rae‐Chi; Inskip, Hazel; Lertxundi, Aitana; Mensink‐Bout, Sara M.; Nader, Johanna; Pizzi, Costanza; Popović, Maja; Salika, Theodosia; Sunyer, Jordi; Meel, Evelien R. van; Swertz, Morris A.; Jaddoe, Vincent W. V.; Burton, Paul R.; Duijts, Liesbeth; Andersen, Anne‐Marie Nybo

doi:10.1016/j.jaci.2022.01.023

Cited by 32 publications

(36 citation statements)

References 87 publications

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“…We also found that the rs2305480 asthma-risk allele increased the risk of lateonset and persistent wheeze. Consistent with the recently reported results of a very large meta-analysis on European children, 14 we found no association between dog and cat ownership in the first year of life and asthma or any wheeze outcome when studied in the whole population. When the interaction between genotype and pet ownership was investigated, our most striking finding was that among dog owners, this most replicated asthma risk allele (rs2305480_G) was no longer associated with an increased risk of asthma or any wheeze phenotype.…”

Section: Discussionsupporting

confidence: 92%

“…9 Previous studies on rs2305480 interaction with environmental exposures already identified maternal smoking and tobacco smoke exposure in early life as an asthma risk factor. 10,11 Because sensitization to cats and dogs is a common feature of childhood asthma, environmental exposure to pets in early life in relation to asthma development has been widely investigated, but epidemiologic studies showed inconsistent results, [12][13][14] possibly reflecting different effects of cats and dogs, and differing genetic susceptibilities of study subjects. Four studies have focused on the interaction between 17q12-q21 SNPs and pet ownership, but the study designs and the findings were heterogeneous, [15][16][17][18] The aim of this study was to evaluate the gene-environment interaction between the missense variant rs2305480 from 17q12-q21 locus and cat and dog ownership in infancy (separately) in relation to the novel wheeze classes in the STELAR cohorts and to a more commonly used asthma definition.…”

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confidence: 99%

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Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Tutino¹,

Granell²,

Curtin³

et al. 2023

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Tutino¹,

Granell²,

Curtin³

et al. 2023

Journal of Allergy and Clinical Immunology

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“…On the other hand, the effect of pet ownership on the development of allergic diseases still remains inconsistent. Recently, a meta‐analysis from EU Child Cohort Network showed that pet ownership during early life was not associated with allergic sensitization to dogs 54 . According to Liccardi and colleagues, indirect allergen exposure should be investigated, in addition to pet ownership, to evaluate the real exposure to dog allergens in a more accurate way 55,56 .…”

Section: Discussionmentioning

confidence: 99%

Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Ermis

Borres

Basna

et al. 2022

Clin Experimental Allergy

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Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a populationbased and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein).Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma.Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and | ME THODS | Study participantsThe study data were derived from an ongoing population-based longitudinal study, the West Sweden Asthma Study (WSAS). Details of the study procedures have been described elsewhere. 25,26 We sent out 30,000 postal questionnaires to randomly selected 16-75-year-old adults living in the Västra Götaland region of Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion:Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization. K E Y W O R D Scomponent resolved diagnostics, dog allergy, dog dander sensitization, dog molecular allergen components, furry animal allergy, Can f 1, Can f 5 Key Message• Can f 1 (43%) and Can f 5 (33%) were the most commonly sensitized single components.

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“…The association between allergen exposures, sensitization, and asthma observed in epidemiological studies, and the findings that high allergen exposure early in life combined with the development of allergic sensitization increases the risk of subsequently developing asthma symptom, 13,73 prompted several primary prevention studies to ascertain whether allergen control during pregnancy and early life can modify the risk of the development of these clinical outcomes (reviewed in 74 ). Due to the differences between the studies in design and characteristics of included populations, the results are not directly comparable.…”

Section: Allerg En Avoidan Ce In Primary Pre Venti On Of S En S Itiz ...mentioning

confidence: 99%

Environmental influences on childhood asthma: Allergens

Čustović

Moira

Murray

et al. 2023

Pediatric Allergy Immunology

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Exposure to inhalant allergens (primarily house-dust mites, cat and dog allergens) is important in the development of allergen-specific sensitization, and if asthma has developed, further allergen exposure may contribute to ongoing symptoms. However, the relationship between allergen exposure and sensitization is complex. To develop allergen-specific sensitization, one needs to be exposed to that allergen. The absence of a consistent, linear dose-response relationship between specific allergen exposures and sensitization has necessitated the application of more complex approaches to attempt to understand these inter-relationships-an essential step in would-be disease prevention. In real life, humans are simultaneously exposed to a mixture of allergens, together with a range of other

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Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network

Cited by 32 publications

References 87 publications

Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Environmental influences on childhood asthma: Allergens

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