Associations of MTHFR rs1801133 (677C&gt;T) and rs180113 (1298A&gt;C) Polymorphisms with Susceptibility to Bladder Cancer: A Systematic Review and Meta-Analysis

Farshid, Saman; Alijanpour, Abolhasan; Barahman, Maedeh; Dastgheib, Seyed Alireza; Narimani, Nima; Shirinzadeh-Dastgiri, Zahra; Maleki, Hadi; Asadian, Fatemeh; Mazaheri, Mahta; Neámatzadeh, Hossein

doi:10.31557/apjcp.2022.23.5.1465

Cited by 7 publications

(5 citation statements)

References 59 publications

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“…I 2 statistic was also utilized to qualify between-study heterogeneity (range of 0 to 100%: I 2 =0-25%, no heterogeneity; I 2 =25-50%, moderate heterogeneity; I 2 = 50-75%, large heterogeneity; I 2 =75-100%, extreme heterogeneity) [29][30][31]. Therefore, a random-effects model (DerSimonian and Laird method) or fixed-effects model (Mantel-Haenszel method) was used to calculate pooled effect estimates in the presence or absence of heterogeneity, respectively [32][33][34]. Moreover, Hardy-Weinberg equilibrium (HWE) assessed by chi-square test was made in control group of each study [35][36][37][38], P>0.05 were considered to have reliable and representative controls.…”

Section: Discussionmentioning

confidence: 99%

Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis

Alijanpour,

Golshan,

Vakili-Ojarood

et al. 2024

Asian Pac J Cancer Prev

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Breast cancer is the most-commonly diagnosed malignant tumor in women in the world, as well as the first cause of death from malignant tumors [1][2][3]. Breast cancer patients account for as much as 36% of oncological patients. An estimated 287,850 new cases women were diagnosed with breast cancer in USA and 43,250 women will die from breast cancer in 2022 [4,5]. The occurrence of breast cancer is associated with many risk factors, including genetic and hereditary predisposition [6,7]. Breast cancers are highly heterogeneous [8,9]. There is growing evidence that germline mutations in certain genes

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Section: Discussionmentioning

confidence: 99%

Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis

Alijanpour,

Golshan,

Vakili-Ojarood

et al. 2024

Asian Pac J Cancer Prev

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“…Both CβS and MTHFR did not exhibited associations with HPV infection or major lesions. Meta-analyses, other reviews, and original papers have been describing associations of this MTHFR variant with several types of cancers, such as ovarian cancer, breast cancer, colorectal cancer, bladder cancer, lung cancer, childhood acute lymphoblastic leukemia [71][72][73][74][75][76], and even cervical cancer [77][78][79][80][81]. However, such associations remain contentious [82][83][84][85], potentially due to population differences [81].…”

Section: Discussionmentioning

confidence: 99%

Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes

Inácio,

Aguiar,

Rodrigues

et al. 2023

Antioxidants

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Human papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress is known to play a crucial role in HPV infection and carcinogenesis. In this study, we comprehensively investigate the modulation of HPV infection, HSIL and ICC, and ICC through an exploration of oxidative stress-related genes: CβS, MTHFR, NOS3, ACE1, CYBA, HAP, ACP1, GSTT1, GSTM1, and CYP1A1. Notably, the ACE1 gene emerges as a prominent factor with the presence of the I allele offering protection against HPV infection. The association of NOS3 with HPV infection is perceived with the 4a allele showing a protective effect. The presence of the GSTT1 null mutant correlates with increased susceptibility to HPV infection, HSIL and ICC, and ICC. This study also uncovers intriguing epistatic interactions among some of the genes that further accentuate their roles in disease modulation. Indeed, the epistatic interactions between the BB genotype (ACP1) and DD genotype (ECA1) were shown to increase the risk of HPV infection, and the interaction between BB (ACP1) and 0.0 (GSTT1) was associated with HPV infection and cervical lesions. These findings underscore the pivotal role of four oxidative stress-related genes in HPV-associated cervical lesions and cancer development, enriching our clinical understanding of the genetic influences on disease manifestation. The awareness of these genetic variations holds potential clinical implications.

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“…However, stratification by ethnicity revealed that the association only existed in Asians and Europeans, but not in Americans and Africans. Another systematic review, which comprised 20 case-control studies, investigated the association between MTHFR polymorphisms and the risk of bladder cancer, revealing no overall association, but when data were stratified by ethnicity, both C677T and A1298C were associated with the risk of bladder cancer only in Asians and not Europeans 18 .…”

Section: Mtfhr Polymorphisms: Challenges In Interpretationmentioning

confidence: 99%

MTHFR genetic testing: is there a clinical utility?

Planello,

Villela,

Loureiro

2024

Rev. Assoc. Med. Bras.

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Associations of MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) Polymorphisms with Susceptibility to Bladder Cancer: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 59 publications

Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis

Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis

Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes

MTHFR genetic testing: is there a clinical utility?

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