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Background: Epidermal cysts are mostly benign tumors with a dome-like appearance usually observed in the body, behind the ears, and in the cervical area. Objectives:The study aimed to compare the surgical results of minimal excision and elliptical excision techniques in the surgical management of epidermal cysts. Methods: In a 24-month period, from 2012 to 2015, 356 patients with benign, non-infected epidermal cysts were surgically managed with minimal excision (n = 178) or elliptical excision (n = 178) techniques. Patient information, volume and place of the lesion, the length of the wound, the time of surgical procedure, and recurrence rate were evaluated using SPSS software at a significance level of < 0.05.

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Nimodipine is a US Food and Drug Administration approved drug that has been shown to act as a possible pharmacologic treatment for facial nerve injury. The objective was to assess the effect of locally administered nimodipine on transected peripheral nerve regeneration and functional recovery. Sixty male healthy white Wistar rats were divided into four experimental groups (n = 15), randomly: In transected group (TC), left sciatic nerve was transected and stumps were fixed in the adjacent muscle. In treatment group defect was bridged using an inside-out artery graft (IOAG/Nimodipine) filled with 10 μL nimodipine (100 ng/mL). In artery graft group (IOAG), the graft was filled with phosphate-buffered saline alone. In sham-operated group (SHAM), sciatic nerve was exposed and manipulated. Each group was subdivided into three subgroups of five animals each and regenerated nerve fibers were studied 4, 8 and 12 weeks after surgery. Behavioral testing, biomechanical studies, sciatic nerve functional study, gastrocnemius muscle mass and morphometric indices confirmed faster recovery of regenerated axons in IOAG/Nimodipine than IOAG group (p < 0.05). In immunohistochemistry, location of reactions to S-100 in IOAG/Nimodipine was clearly more positive than that in IOAG group.When loaded in an artery graft nimodipine accelerated and improved functional recovery and morphometric indices of sciatic nerve. This may have clinical implications for the surgical management of patients after facial nerve transection.

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