Associations of parameters characterizing the time course of the tabletting process on a reciprocating and on a rotary tabletting machine for high-speed production

Konkel, Peter; Mielck, Jobst B.

doi:10.1016/s0939-6411(97)00132-x

Cited by 18 publications

(11 citation statements)

References 7 publications

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“…4). Rees and Konkel had also reported the pressure dependency of the apparent mean yield pressure (34,35). Heckel analysis does not accurately describe the compaction of pharmaceutical powders at high compaction pressures, because small error in determination of relative density might cause significant error in the logarithmic transformations.…”

Section: Heckel Analysismentioning

confidence: 99%

Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility

2006

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Section: Heckel Analysismentioning

confidence: 99%

Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility

2006

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“…30 In the present form 31 it is able to describe the normalized pressure-time curve of the tableting process in an eccentric tableting machine. The equation is as follows:…”

Section: Pressure-time Functionmentioning

confidence: 99%

Evaluation of powder and tableting properties of chitosan

Picker‐Freyer

Brink

2006

AAPS PharmSciTech

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The aim of this study was to analyze the process of tablet formation and the properties of the resulting tablets for 3 Ndeacetylated chitosans, with a degree of deacetylation of 80%, 85%, or 90%. Material properties, such as water content, particle size and morphology, glass transition temperature, and molecular weight were studied. The process of tablet formation was analyzed by 3-D modeling, Heckel analysis, the pressure time function, and energy calculations in combination with elastic recovery dependent on maximum relative density and time. The crushing force and the morphology of the final tablets were analyzed. Chitosans sorb twice as much water as microcrystalline cellulose (MCC), the particle size is comparable to Avicel PH 200, a special type of MCC, the particles look like shells, and the edges are bent. Molecular weight ranges from 80 000 to 210 000 kDa, the glass transition temperature (Tg) was not dependent on molecular weight. The chitosans deform ductilely as MCC; however, plastic deformation with regard to time and also pressure plasticity are higher than for MCC, especially for Chit 85, which has the lowest crystallinity and molecular weight. At high densification, fast elastic decompression is higher. 3-D modeling allowed the most precise analysis. Elastic recovery after tableting is higher than for MCC tablets and continues for some time after tableting. The crushing force of the resulting tablets is high owing to a reversible exceeding of Tg in the amorphous parts of the material. However, the crushing force is lower compared with MCC, since the crystallinity and the Tg of the chitosans are higher than for MCC. In summation, chitosans show plastic deformation during compression combined with high elasticity after tableting. Highly mechanically stable tablets result.

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“…On a rotary tablet press, the force-time curves are segmented into three phases-compression phase, dwell phase, and decompression phase. Consolidation time is the time to reach maximum force, dwell time is the time at which maximum displacement occurs, and contact time is the time for compression and decompression 24 .  Force-Displacement Profile: Stress relaxation is observed to be less in case of plastic deformation; where as materials that undergoes elastic deformation tend to relax to a greater extent during and/or after decompression.…”

Section: Physics Of Compressionmentioning

confidence: 99%

Untitled

2012

IJPSR

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Due to various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped making tablets the most popular dosage forms among all available dosages forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e. reduction of volume of the powder under consideration and particle rearrangement) and consolidation (i.e., formation of interparticulate bond to facilitate stable compaction). The success of the compaction process depends not only on the physico-technical properties of drugs and excipients, but also on the instrument settings with respect to rate and magnitude of force transfer. Tablet manufacturing speed and pre/main compression force profile also have an influence on the quality of the final tablet. Mechanical aspects of tablet formation can be studied using, instrumented punches/dies, instrumented tablet punching machines, and compaction simulators. These have potential application in pharmaceutical research and development, such as studying basic compaction mechanism, various process variables, scale-up parameters, trouble shooting problems, creating compaction data library, and fingerprinting of new active pharmaceutical ingredients (APIs) or excipients. Mathematical models, forcetime, force-distance, and die-wall force parameters of tablet manufacturing are used to describe work of compaction, elasticity/plasticity, and time dependent deformation behavior of pharmaceuticals powder under consideration.

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Associations of parameters characterizing the time course of the tabletting process on a reciprocating and on a rotary tabletting machine for high-speed production

Cited by 18 publications

References 7 publications

Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility

Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility

Evaluation of powder and tableting properties of chitosan

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