Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness

Levy, Daniel; Hwang, Shih Jen; Kayalar, Atilla; Benjamin, Emelia J.; Vasan, Ramachandran S.; Parise, Helen; Larson, Martin G.; Wang, Thomas J.; Selhub, Jacob; Jacques, Paul F.; Vita, Joseph A.; Keyes, Michelle J.; Mitchell, Gary F.

doi:10.1161/circulationaha.106.652842

Cited by 52 publications

(46 citation statements)

References 60 publications

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“…10, 11 Kaji et al reported the existence of an association between plasma BNP levels and the radial AI. 13 In the Framingham study, Levy et al demonstrated the existence of a significant association of the plasma BNP levels with not only the carotid-femoral PWV, but also with the carotid pulse pressure in men, but not in women. 13 However, no study has ex- independent predictor of future cardiovascular events; 2,14,17 elevated aortic pressure, renal impairment and inflammation have been proposed as possible mechanisms underlying the increased cardiovascular risk associated with elevated CPP.…”

Section: Discussionmentioning

confidence: 99%

“…13 In the Framingham study, Levy et al demonstrated the existence of a significant association of the plasma BNP levels with not only the carotid-femoral PWV, but also with the carotid pulse pressure in men, but not in women. 13 However, no study has ex- independent predictor of future cardiovascular events; 2,14,17 elevated aortic pressure, renal impairment and inflammation have been proposed as possible mechanisms underlying the increased cardiovascular risk associated with elevated CPP. 21 In the stepwise multivariate analysis in this study, in which all parameters related to arterial stiffness/central hemodynamics were entered simultaneously as covariates, only PP2 was found to show a significant relationship with the serum NT-pro BNP levels.…”

Section: Discussionmentioning

confidence: 99%

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Strength of Relationships of the Pulse Wave Velocity and Central Hemodynamic Indices With the Serum N-Terminal Fragment B-Type Natriuretic Peptide Levels in Men

Odaira

Tomiyama

Matsumoto

et al. 2012

Circ J

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Strength of Relationships of the Pulse Wave Velocity and Central Hemodynamic Indices With the Serum N-Terminal Fragment B-Type Natriuretic Peptide Levels in Men

Odaira

Tomiyama

Matsumoto

et al. 2012

Circ J

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“…Of note, discordant results have been found when considering the relationship between BNP and other markers of arterial stiffness such as carotid-radial or femoral pulse wave velocity. 23 This suggests that pulse wave velocity and carotid b index do not necessarily provide similar information.…”

Section: Carotid Arterial Stiffness Bnp and Symptomatic Status In Asmentioning

confidence: 99%

Carotid Artery and Aortic Stiffness Evaluation in Aortic Stenosis

Weisz

Magné

Caso

et al. 2014

Journal of the American Society of Echocardiography

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Background: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (b index). The aim of this study was to investigate the relationship between carotid and aortic b index, left ventricular (LV) function, plasma brain natriuretic peptide (BNP) level, and symptoms in patients with AS.

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“…[6][7][8][9] Furthermore, the effect of Hcy on arterial stiffness in patients with DM has not been extensively investigated, despite its known association with macro-and microvascular complications of DM. 10,11 In this background, we aimed to evaluate the association of Hcy concentrations and arterial stiffness in subjects with type 2 DM using brachial-ankle pulse wave velocity (baPWV)…”

Section: 4mentioning

confidence: 99%

Association of Plasma Homocysteine Level and Arterial Stiffness in Subjects with Type 2 Diabetes Mellitus

Hwang

Jung

Lee

et al. 2013

J Lipid Atheroscler

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Objective: Plasma homocysteine (Hcy) is considered to be a marker of endothelial dysfunction and a predictor of cardiovascular disease (CVD). Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of CVD. Previous studies about the effect of high plasma Hcy levels on arterial stiffness have yielded inconsistent results. We therefore assessed the association between Hcy and baPWV in a relatively large number of subjects with type 2 diabetes mellitus (DM). Methods: We retrospectively assessed plasma Hcy concentration and arterial stiffness in 1,477 Korean type 2 diabetic patients. Participants were also evaluated for plasma glucose, hemoglobin A1c (HbA1c), duration of DM, microvascular complications, lipid profile, and high sensitivity C-reactive protein (hsCRP). Arterial stiffness was measured noninvasively by baPWV. Results: Correlation analysis indicated a significant positive association between serum Hcy levels and baPWV (r=0.245, p<0.001). In a multiple linear regression analysis, the association between serum Hcy levels and baPWV was independent of traditional cardiovascular risk factors (standardized β=3.8, p=0.01). Conclusion:The results support the hypothesis that plasma Hcy levels are associated with arterial stiffness in patients with type 2 DM. Prospective studies are warranted to determine whether lowering serum Hcy level could reduce arterial stiffness and cardiovascular morbidity in type 2 DM.

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Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness

Abstract: Background-Increased arterial stiffness and higher plasma natriuretic peptide and homocysteine levels are associated with elevated risk for cardiovascular disease. Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community.

Cited by 52 publications

References 60 publications

Strength of Relationships of the Pulse Wave Velocity and Central Hemodynamic Indices With the Serum N-Terminal Fragment B-Type Natriuretic Peptide Levels in Men

Strength of Relationships of the Pulse Wave Velocity and Central Hemodynamic Indices With the Serum N-Terminal Fragment B-Type Natriuretic Peptide Levels in Men

Carotid Artery and Aortic Stiffness Evaluation in Aortic Stenosis

Association of Plasma Homocysteine Level and Arterial Stiffness in Subjects with Type 2 Diabetes Mellitus

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