Associations of Polymorphisms of the &amp;lt;i&amp;gt;CYP&amp;lt;/i&amp;gt;1&amp;lt;i&amp;gt;A&amp;lt;/i&amp;gt;1 and &amp;lt;i&amp;gt;CYP&amp;lt;/i&amp;gt;1&amp;lt;i&amp;gt;B&amp;lt;/i&amp;gt;1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan

Balmukhanov, T. S.; Khanseitova, A. K.; Nigmatova, V. G.; Varchenko, S. P.; Talaeva, Sh. Zh.; Аitkhozhinа, N. А.

doi:10.4236/abcr.2013.23009

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…CYP1A1 is located on chromosome 15 and comprises seven exons and six introns that span 5810 base pairs [25]. The contribution of CYP1A1 to estrogen metabolism and polycyclic aromatic hydrocarbon (PAH) carcinogen metabolism points to its involvement in breast cancer [26].…”

Section: Discussionmentioning

confidence: 99%

Association of rs4646903 and rs1048943 CYP1A1 estrogen-metabolizing gene polymorphisms with estrogen receptor-positive breast cancer in Kenyan women

Murithi

Nyanjom

Mobegi

et al. 2023

ARCH BIOL SCI BELGRA

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Breast cancer is the most prevalent neoplasm and the second leading cause of death among females in Kenya. Estrogen and its metabolites are known risk factors for breast cancer. Polymorphisms in these genes and breast cancer susceptibility are unique among different populations. This study aimed to determine the probable associations between estrogen-metabolizing gene variations and other risk factors for breast cancer risk in Kenyan women. Buffy coat samples were obtained from patients diagnosed with estrogen receptor-positive breast cancer, benign breast disease, and healthy volunteers. Genotyping of target polymorphisms was conducted using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis. The rs4646903 variant genotype CC was associated with breast cancer in the case-control model (P=0.001); the heterozygous genotype TC (P=0.01) and the luminal B molecular subtype (P=0.02) showed increased odds of late-stage breast cancer. The rs1048943 variant genotype GG was associated with breast cancer in the case-benign model (P=0.04), whereas CG was associated with breast cancer in the case-control model (P=0.02). These findings imply that the rs4646903 and rs1048943 variant genotypes are involved in breast cancer risk in Kenyan women. Hence, they may be explored further as potential markers for the disease.

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Section: Discussionmentioning

confidence: 99%