Asymmetric cationic liposomes designed for heat-activated association with cells

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

“…And optimized clinical trial has been carried out. Jing et al developed an asymmetric liposome to enhance drug intracellular release based on thermal triggered endocytosis [ 25 ]. The so-called asymmetric liposomes are lipid bilayers with different components of inward and outward membrane ( Figure 3(b) ).…”

“… Thermal response for lipid phase control. (a) Nearly 80% of DOX releases in 20 seconds under 42°C in TSL contained MSPC [ 23 ]; (b) asymmetric liposomes with different components of inward and outward membrane enhance endocytosis after thermal stimulation [ 25 ]; (c) edge stabilizer SC-C5 gives bicelles dilution tolerance and thermoresponsiveness since it has extremely low CMC [ 38 ]; (d) thermosensitive on/off switch liposome achieves a reversible drug release on demand [ 40 ]. …”

Asymmetric Lipid Vesicles: Techniques, Applications, and Future Perspectives as an Innovative Drug Delivery System

“…Jing et al designed asymmetric lipid membranes in which the asymmetry was generated through the selective PEGylation of cationic lipids in the outer membrane leaflet, so an asymmetry between two membrane leaflets of liposomes was created while the charged surface function at the outer liposome surface of the symmetric liposomes was deactivated. This study mentions the importance of designing improved anticancer drugs and of using drug carriers in combination therapies [ 48 ].…”

“…While artificial lipid bilayers are useful to model natural membranes, they are generally symmetric and lack at least some of the critical structural characteristics of natural cell membranes. Since cellular membranes have different lipid domains in different parts of the membrane that are required to control different cellular activities that are essential for differentiation, proliferation, protein interactions, and cell-to-cell communication [ 48 , 49 , 54 ], symmetric bilayers lack the capacity to emulate these behaviors, thus limiting the information obtained from working with this kind of model. Therefore, asymmetric systems could improve our understanding of cellular processes due to their resemblance with the asymmetric behavior of eukaryotic or bacterial cellular membranes [ 49 , 55 , 56 ].…”

“…Jing et al designed asymmetric lipid membranes in which the asymmetry was generated through the selective PEGylation of cationic lipids in the outer membrane leaflet, so an asymmetry between two membrane leaflets of liposomes was created while the charged surface function at the outer liposome surface of the symmetric liposomes was deactivated. This study mentions the importance of designing improved anticancer drugs and of using drug carriers in combination therapies [48]. Asymmetric-type liposomes continue to be studied for their application in the release of different drugs, so it is expected that in the future, the control over the layers of these nanosystems, as well as the benefits that these kinds of liposomes have, will lead to their application in drugs that require a more sustained release as well as better doses and routes of administration.…”