Asymmetric serial interactions between ethanol and cocaine in taste aversion learning

Grakalic, Ivana; Riley, Anthony L.

doi:10.1016/s0091-3057(02)00905-x

Cited by 14 publications

(4 citation statements)

References 85 publications

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“…Also, given the effects of MDPV history on cocaine-induced taste avoidance, similar work needs to be extended to cocaine’s rewarding (CPP) and reinforcing (SA) effects. Further, given that the effects of drug history have been reported to be asymmetrical for some compounds, i.e., Drug A affects Drug B, but not vice versa (for a discussion, see Grakalic and Riley, 2002; for a review, see Riley and Simpson, 2001), the impact of cocaine on MDPV needs further assessment as well. It is interesting to note that several studies assessing the serial interactions between cathinones and psychostimulants (see Gregg, 2013; Watterson et al, 2016), the interaction was asymmetrical.…”

Section: Discussionmentioning

confidence: 99%

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Woloshchuk

Nelson

Rice

et al. 2016

Drug and Alcohol Dependence

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Background Drug use is thought to be a balance of the rewarding and aversive effects of drugs. Understanding how various factors impact these properties and their relative balance may provide insight into their abuse potential. In this context, the present study attempted to evaluate the effects of drug history on the aversive effects of 3,4-methylenedioxypyrovalerone (MDPV), one of a variety of synthetic cathinones (collectively known as “bath salts”). Methods Different groups of male Sprague-Dawley rats were exposed to either vehicle or MDPV (1.8 mg/kg) once every fourth day for five total injections prior to taste avoidance conditioning in which a novel saccharin solution was repeatedly paired with either vehicle, MDPV (1.8 mg/kg), the related psychostimulant cocaine (18 mg/kg) or the emetic lithium chloride (LiCl) (13.65 mg/kg). Results In animals pre-exposed to vehicle, all three drugs induced significant and comparable taste avoidance relative to animals injected with vehicle during conditioning. MDPV pre-exposure attenuated the avoidance induced by both MDPV and cocaine (greater attenuation for MDPV than cocaine), but had no effect on that induced by LiCl. Conclusions These findings suggest that a history of MDPV use may reduce or attenuate MDPV and cocaine’s (but not LiCl’s) aversive effects. The implications for such changes in MDPV’s aversive effects to its potential use and abuse were discussed.

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Section: Discussionmentioning

confidence: 99%

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Woloshchuk

Nelson

Rice

et al. 2016

Drug and Alcohol Dependence

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“…For example, Braveman (1975) reported that pre-exposure to methylscopolamine attenuated LiCl-and amphetamine-induced taste aversions. Conversely, Etkind et al (1998) found that aversions induced by cocaine (SC) and ethanol (IP) administered concurrently were significantly greater than those induced by either drug alone, as well as the summation of the aversions produced by each drug, implicating an interaction between the two substances (see also Grakalic and Riley 2002;Jones et al 2006).…”

Section: Introductionmentioning

confidence: 99%

The effects of nicotine on ethanol-induced conditioned taste aversions in Long–Evans rats

et al. 2008

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These data demonstrate that nicotine may interact with ethanol, increasing ethanol's aversive effects. Although the rewarding effects of concurrently administered nicotine and ethanol were not assessed, these data do indicate that the reported high incidence of nicotine and ethanol co-use is unlikely due to reductions in the aversiveness of ethanol with concurrently administered nicotine. It is more likely attributable to nicotine-related changes in ethanol's rewarding effects.

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“…If cocaine-induced CTAs are mediated to any degree by this same mechanism, preexposure (and the accompanying tolerance) should result in an attenuation of cocaine-induced CTAs. It is interesting in this context that such asymmetrical cross-drug preexposure effects have been reported for other combinations of drugs (De Beun et al, 1996; Gommans et al, 1998; Goudie and Thornton, 1975; see also Riley and Simpson, 2001; see Grakalic and Riley, 2002; Serafine and Riley, 2009; 2010 for examples with cocaine) and are generally interpreted as evidence of similar, but non-identical, mechanisms responsible for the induction of CTAs by the two compounds.…”

Section: Methodsmentioning

confidence: 90%

Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909

Serafine

Briscione

Rice

et al. 2012

Pharmacology Biochemistry and Behavior

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Although cocaine readily induces taste aversions, little is known about the mechanisms underlying this effect. It has been suggested that its inhibitory effects at one of the monoamine transporters may be mediating this suppression. Using the cross-drug preexposure preparation, the present series of studies examined a possible role of dopamine (DA) in this effect. Male Sprague-Dawley rats were exposed to cocaine (18 mg/kg; Experiment 1) or the selective DA transporter (DAT) inhibitor GBR 12909 (50 mg/kg; Experiment 2) prior to the pairing of a novel saccharin solution with injections of GBR 12909 (32 mg/kg), cocaine (18 mg/kg) or vehicle in a conditioned taste aversion (CTA) procedure. Preexposure to cocaine attenuated aversions induced by itself but not aversions induced by GBR 12909 (Experiment 1). Conversely, preexposure to GBR 12909 attenuated aversions induced by itself and cocaine (Experiment 2). This asymmetry suggests that cocaine and GBR 12909 induce CTAs via similar, but non-identical, mechanisms. These data are discussed in the context of previous work demonstrating roles for dopamine, norepinephrine and serotonin in cocaine-induced CTAs.

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Asymmetric serial interactions between ethanol and cocaine in taste aversion learning

Cited by 14 publications

References 85 publications

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

The effects of nicotine on ethanol-induced conditioned taste aversions in Long–Evans rats

Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909

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