Atenolol Attenuates Autonomic Dysfunction of Rat Jejunum Submitted to Cold Ischemic Preservation

Taha, Murched Omar; Fraga, Melissa Mariti; Guimarães, F.A.G.; Jurkiewicz, Aron; Caricati‐Neto, Afonso

doi:10.1016/j.transproceed.2006.05.024

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…In this way, drugs and cellular protector strategies to prevent or to attenuate systemic organ dysfunction must be investigated. Many types of strategies has been studied [5][6][7][8][9][10][11] , such as exogenous Adenosine treatment [12][13][14][15][16] and ischemic preconditioning [17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Heart injury following intestinal ischemia reperfusion in rats is attenuated by association of ischemic preconditioning and adenosine

Montero¹,

Saurim

Bonservizi

et al. 2014

Acta Cir. Bras.

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PURPOSE:To investigate the effect of ischemic preconditioning (IPC) and adenosine as strategies to protect cardiac injury caused by intestinal IR in rats, based on increasing in adenosine bioavailability and improvement of cell energy state by IPC. METHODS:Male Wistar rats were submitted to 60 minutes of intestinal ischemia and 120 minutes of reperfusion. Intravenous injections of saline or Adenosine (AD) was administered five minutes before ischemia, five minutes before reperfusion and after 55 minutes reperfusion. Cardiac samples were obtained, fixed in formalin solution, embedded in paraffin, and sections of 5 μm were stained by hematoxylin-eosin. Histological analysis of myocardium was performed according occurrence of necrosis signs: piknosis, band contraction, eosinophilic cytoplasm, karyorrhexis and vacuolization (score -zero to 5). RESULTS:The groups submitted to ischemia alone (I=4.0), and reperfusion (IR=4.5) showed highest level of lesion compared to the others (I+IPC=3.3, IR+IPC=3.6, I+AD=3.0, IR+AD=3.8). The most interesting result was association of IPC and AD in IR model (IR+IPC+AD=1.2, p=0.002), showing preservation of the heart tissue, with fibers showing typical cross-striations and nuclei characteristics. Rare and small areas of tissue necrosis was observed and suggestion of capillaries congestion. CONCLUSION:Intestinal ischemia reperfusion promotes cardiac tissue injury. Ischemic preconditioning in association with adenosine is an efficient strategy to protect the heart against ischemia and reperfusion injury.

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Section: Introductionmentioning

confidence: 99%

Heart injury following intestinal ischemia reperfusion in rats is attenuated by association of ischemic preconditioning and adenosine

Montero¹,

Saurim

Bonservizi

et al. 2014

Acta Cir. Bras.

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Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle

Jurkiewicz

Caricati‐Neto

Jurkiewicz

2009

An. Acad. Bras. Ciênc.

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The term functionomics (Amin 2003, Neumann et al. 2004 refers to a postgenomic integrated Systems Biology (Attur et al. 2002) using a multidimensional approach for cells, tissues and organs. It considers current or future involvement among genomics, proteomics or metabolomics, including the main factors that cause biological responses and modulation under different conditions. Our objective in the present review is to summarize the contemporary understanding of functionomics of smooth muscle pharmacology, based on the results obtained on the pregenomic era during several years in our laboratory. The present approach is based on the knowledge of the dynamics of the receptor system, which comprises a cascade of phenomena, leading from the drug administration to the final biological response. We will describe several conditions in which the final effect is modified, based on perturbations induced on drug absorption, distribution, metabolism, interaction with receptors and mobilization of second messengers, as well as by interactions with a second receptor system. We will also discuss the gaps that need to be fulfilled in order to obtain a clear and better understanding of the receptor system in smooth muscle, and to narrow the bridge between our knowledge of the function of biological systems, genomics, and other recently introduced areas.

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Atenolol Attenuates Autonomic Dysfunction of Rat Jejunum Submitted to Cold Ischemic Preservation

Cited by 2 publications

References 19 publications

Heart injury following intestinal ischemia reperfusion in rats is attenuated by association of ischemic preconditioning and adenosine

Heart injury following intestinal ischemia reperfusion in rats is attenuated by association of ischemic preconditioning and adenosine

Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle

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