Atopic dermatitis (eczema) in
            <scp>US</scp>
            female nurses: lifestyle risk factors and atopic comorbidities

Drucker, Aaron M.; Li, W.‐Q.; Lin, Lizi; Cho, Eunyoung; Li, T.; Camargo, Carlos A.; Qureshi, Abrar A.

doi:10.1111/bjd.14373

Cited by 20 publications

(27 citation statements)

References 6 publications

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“…In addition, we now have sub‐populations of refined confirmed AD cases within the cohort. These findings provide some reassurance about the validity of our previous analyses on AD in this cohort and are encouraging for future work . Future analyses in NHS2 can explore associations of AD using multiple case definitions, adding to the robustness of their findings.…”

Section: Discussionsupporting

confidence: 61%

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Diagnosis validation and clinical characterization of atopic dermatitis in Nurses’ Health Study 2

Drucker

Cho

et al. 2019

Acad Dermatol Venereol

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Background Epidemiologic studies of atopic dermatitis (AD) are often limited by case definitions that have not been validated. Objective In this study, we assessed the accuracy of self‐report of AD in a large cohort of US female nurses, the Nurses’ Health Study 2 (NHS2). We also provide clinical characteristics of AD in the cohort. Methods We sent an electronic questionnaire to NHS2 participants who previously reported ever having a diagnosis of AD. This questionnaire was designed to confirm cases of AD using previously validated algorithms with >85% specificity. We assessed the association of AD with asthma, comparing the results when different definitions of AD were applied. We also inquired about various aspects of participants’ AD. Results Responses were received from 2509 of 5126 (49%) nurses who were sent the questionnaire, with an average age of 62. Most participants (1996/2509, 80%) reiterated their previously reported clinician diagnosis of AD. Application of the two diagnostic algorithms yielded confirmation of 1538 and 1293 prevalent cases, respectively. The association of AD with asthma was stronger when more stringent AD case definitions were applied. Participants generally reported mild disease (92% with ≤10% maximal body surface area involved) and a high proportion (57%) reported adult‐onset disease. Conclusions Self‐report of AD diagnosis has good reliability, and future analyses will be strengthened by our ability to conduct sensitivity analyses with refined confirmed AD subgroups.

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Section: Discussionsupporting

confidence: 61%

“…Our research group has published AD‐related analyses using data from Nurses’ Health Study 2 (NHS2), an ongoing cohort of US female nurses, which relies on self‐report of ever receiving a clinician diagnosis of AD for its case definition . Participants are also asked what year they were diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis validation and clinical characterization of atopic dermatitis in Nurses’ Health Study 2

Drucker

Cho

et al. 2019

Acad Dermatol Venereol

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“…and Egeberg et al . reported increased alcohol intake in AD patients compared with that in the reference group, while Drucker et al . reported no difference.…”

Section: Discussionmentioning

confidence: 92%

Dietary habits in adult Japanese patients with atopic dermatitis

Ito

Morita

Okazaki

et al. 2019

The Journal of Dermatology

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Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief‐type self‐administered diet history questionnaire and compared the results to those of age‐ and sex‐matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. The results of logistic regression analysis showed that the intake of alcohol was negatively associated with atopic dermatitis (odds ratio, 0.905; 95% confidence interval, 0.832–0.983; P = 0.0181). The intakes of vitamin B6 and fruit were positively correlated with the severity scoring of atopic dermatitis. Multiple regression analysis revealed that vitamin B6 intake was a predictor of the severity scoring of atopic dermatitis (β = 26.98508709, t = 2.3995292, P = 0.01933781). The intakes of vegetable fat, n‐6 polyunsaturated fatty acid, and confections were lower in the severe atopic dermatitis group (severity scoring of atopic dermatitis, ≥33) than those in the mild group. Atopic dermatitis is negatively associated with alcohol intake, and intake of vitamin B6 is a predictor of severity scoring of atopic dermatitis. The intake of n‐6 polyunsaturated fatty acid is lower in the severe atopic dermatitis group than that in the mild group. Further study is warranted on the relationships of these results with abnormal immune responses, impaired skin barrier or pruritus in atopic dermatitis.

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“…AD has been variably associated with a number of cardiovascular risk factors, including higher BMI, lower physical activity, increased alcohol consumption, cigarette smoking, hypertension, hypercholesterolemia and adult-onset diabetes. (2, 3, 5, 12)…”

Section: Discussionmentioning

confidence: 99%

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women

Drucker

Cho

et al. 2016

Allergy

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We aimed to determine the association between atopic dermatitis (AD) and cardiovascular events in the Nurses' Health Study 2, a cohort of US women. We used logistic regression models to calculate age- and multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between history of AD and non-fatal MI and non-fatal stroke. Of the 78,702 participants in our analysis, 7,916 (10%) had a history of AD. There were 392 and 391 cases of non-fatal MI and stroke, respectively. AD was not associated with MI in age- or multivariate-adjusted analyses. AD was significantly associated with stroke in the age-adjusted analysis (OR 1.38, 95% CI 1.03-1.85). This was no longer significant in multivariate models that adjusted for hypertension, hypercholesterolemia and diabetes (OR 1.31, 95% CI 0.98-1.76) and atopic comorbidities (OR 1.17, 95% CI 0.86-1.58). AD was not independently associated with non-fatal MI or stroke in this study.

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Atopic dermatitis (eczema) in US female nurses: lifestyle risk factors and atopic comorbidities

Cited by 20 publications

References 6 publications

Diagnosis validation and clinical characterization of atopic dermatitis in Nurses’ Health Study 2

Diagnosis validation and clinical characterization of atopic dermatitis in Nurses’ Health Study 2

Dietary habits in adult Japanese patients with atopic dermatitis

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women

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