2010
DOI: 10.1016/j.phrs.2009.11.006
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Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis

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Cited by 33 publications
(13 citation statements)
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“…1, 2). Besides decreasing inflammation, atorvastatin has recently been documented to relieve hyperalgesia and to improve joint functions in the arthritic rats (Wahane and Kumar 2010). Our findings are in agreement with earlier studies of Barsante et al (2005) where they have reported anti-inflammatory and anti-hypernociceptive effects of atorvastatin in chronic arthritis induced by immunization of rats with adjuvant.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…1, 2). Besides decreasing inflammation, atorvastatin has recently been documented to relieve hyperalgesia and to improve joint functions in the arthritic rats (Wahane and Kumar 2010). Our findings are in agreement with earlier studies of Barsante et al (2005) where they have reported anti-inflammatory and anti-hypernociceptive effects of atorvastatin in chronic arthritis induced by immunization of rats with adjuvant.…”
Section: Discussionsupporting
confidence: 93%
“…Besides, they have been shown to afford protection in various experimental models of arthritis by reducing articular inflammation, preventing bone loss and preserving bone mineral density (Yamagata et al 2007;Funk et al 2008). Recently atorvastatin, one of the longer acting and clinically used statins, has been demonstrated to attenuate inflammatory hyperalgesia in a rat model of monoarticular arthritis (Wahane and Kumar 2010).…”
Section: Introductionmentioning
confidence: 99%
“…According to the authors' conclusion, statins accelerate the onset of CIA in mice. In their study, as previously reported [2], oral atorvastatin and pravastatin had no effect on the arthritis score after CIA induction. Nonetheless, the oral route might be ineffective due to the significant hepatic first-pass metabolism of statins.…”
supporting
confidence: 66%
“…Atorvastatin prevented joint inflammation in rat inflammatory arthritis with decreased tissue concentrations of IL-1β, IL-6, TNFα and chemokines 41 42. Statins also reduced the proportion of interferon γ (IFNγ) release by T cells and downregulated expression of inflammatory cytokines by synoviocytes in RA 13 15.…”
Section: Discussionmentioning
confidence: 99%