Atrazine inhibition of testosterone production in rat males following peripubertal exposure

Friedmann, Andrew S.

doi:10.1016/s0890-6238(02)00019-9

Cited by 178 publications

(108 citation statements)

References 13 publications

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“…The similarities between these previous findings in fish (4) and in reptiles (18) and the present findings in an amphibian suggest that the demasculinizing effects of atrazine are also not species, genera, family, or even order specific but occur across vertebrate classes. Indeed, declining androgens (22,26) and decreased sperm production have been shown in laboratory rodents exposed to atrazine as well (22,26,42), albeit at higher doses. Furthermore, atrazine exposure is highly correlated (P < 0.009) with low sperm count, poor semen quality, and impaired fertility in humans (43).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its persistence, mobility, and widespread contamination of water, atrazine is also a concern because several studies have shown that atrazine is a potent endocrine disruptor active in the ppb (parts per billion) range in fish (4, 5), amphibians (6)(7)(8)(9)(10)(11)(12), reptiles, and human cell lines (5,(13)(14)(15), and at higher doses (ppm) in reptiles (16)(17)(18), birds (19), and laboratory rodents (20)(21)(22)(23)(24)(25)(26)(27)(28). Atrazine seems to be most potent in amphibians, where it is active at levels as low as 0.1 ppb (6)(7)(8)(9)(10).…”

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confidence: 99%

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Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)

Hayes

Khoury

Narayan

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

526

307

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The herbicide atrazine is one of the most commonly applied pesticides in the world. As a result, atrazine is the most commonly detected pesticide contaminant of ground, surface, and drinking water. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations. Previous studies showed that atrazine adversely affects amphibian larval development. The present study demonstrates the reproductive consequences of atrazine exposure in adult amphibians. Atrazineexposed males were both demasculinized (chemically castrated) and completely feminized as adults. Ten percent of the exposed genetic males developed into functional females that copulated with unexposed males and produced viable eggs. Atrazineexposed males suffered from depressed testosterone, decreased breeding gland size, demasculinized/feminized laryngeal development, suppressed mating behavior, reduced spermatogenesis, and decreased fertility. These data are consistent with effects of atrazine observed in other vertebrate classes. The present findings exemplify the role that atrazine and other endocrine-disrupting pesticides likely play in global amphibian declines.A trazine is one of the most widely used pesticides in the world. Approximately 80 million pounds are applied annually in the United States alone, and atrazine is the most common pesticide contaminant of ground and surface water (1). Atrazine can be transported more than 1,000 km from the point of application via rainfall and, as a result, contaminates otherwise pristine habitats, even in remote areas where it is not used (2, 3). In fact, more than a half million pounds of atrazine are precipitated in rainfall each year in the United States (2).In addition to its persistence, mobility, and widespread contamination of water, atrazine is also a concern because several studies have shown that atrazine is a potent endocrine disruptor active in the ppb (parts per billion) range in fish (4, 5), amphibians (6-12), reptiles, and human cell lines (5, 13-15), and at higher doses (ppm) in reptiles (16-18), birds (19), and laboratory rodents (20-28). Atrazine seems to be most potent in amphibians, where it is active at levels as low as 0.1 ppb (6-10). Although a few studies suggest that atrazine has no effect on amphibians under certain laboratory conditions (29,30), in other studies, atrazine reduces testicular volume; reduces germ cell and Sertoli cell numbers (11); induces hermaphroditism (6, 8, 10); reduces testosterone (10); and induces testicular oogenesis (7-9, 31). Furthermore, atrazine contamination is associated with demasculinization and feminization of amphibians in agricultural areas where atrazine is used (32) and directly correlated with atrazine contamination in the wild (7,9,33,34).Despite the wealth of data from larvae and newly metamorphosed amphibians, the ultimate impacts of atrazine's developmental effects on reproductive function and fitness at sexual maturity, which relate more closely to population level effects and amphibian declines, have b...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)

Hayes

Khoury

Narayan

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

526

307

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“…A downregulation of Leydig cell steroidogenic gene expression (Pogrmic et al 2009) and reductions in testosterone concentrations have been observed both in serum and in testicular interstitial fluid following 3-4 weeks of exposure (Trentacoste et al 2001, Friedmann 2002, although decreases in body weight with longer treatments were believed to contribute to these endocrine effects. In females, lifetime dietary exposures to ATRZ were found to cause premature reproductive senescence in female Sprague Dawley rats .…”

Section: Introductionmentioning

confidence: 99%

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

et al. 2013

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Multiple exposures to the herbicide atrazine (ATRZ) were shown to suppress the LH surge in both cycling female rats and those ovariectomized (OVX) and primed with estradiol (E 2 ). A single ATRZ administration was found to induce a prompt and marked increase in progesterone (P 4 ). As exogenous P 4 is known to have a differential effect on the LH surge depending on its temporal relationship with the surge, it was hypothesized that a single treatment in an OVX, E 2 -primed rat would augment the surge, whereas several exposures would cause a decrease. Following four daily treatments with 100 mg/kg, LH surge was suppressed. In contrast, a single ATRZ exposure elevated the surge. Two treatments were without effect. The single administration caused a large increase in P 4 at 30 and 60 min that was likely attributable to adrenal secretion. Four exposures also elevated P 4 after the final treatment, although the duration of the increase was shortened. A single treatment with 0, 10, 30, and 100 mg/kg ATRZ showed similar elevations at the highest concentration in P 4 , the LH peak, and area under the curve (AUC), whereas four exposures reduced the AUC. An increase at 1 h in the expression of Kiss1 in the anteroventral periventricular nucleus suggests that this regional kisspeptin neuronal population has a role in the ATRZ augmentation of the surge. These data support the hypothesis that ATRZ-induced changes in adrenal P 4 can either augment or attenuate the surge depending on the temporal proximity of exposure to the rise in LH.

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“…Considerando os problemas de saúde pública que podem ser causados pela presença de ATZ em águas de abastecimento e a limitação dos processos de tratamento, denominados convencionais na remoção desta, a proposta deste trabalho foi avaliar a adsorção em carvão ativado por meio de isotermas em águas com diferentes conteúdos orgânicos. 2002;GIBSON & KOIFMAN, 2008). Nos Estados Unidos e na Europa, a ATZ tem sido encontrada em mananciais em concentrações variando de 2,9 a 89,0 μg.L -1 (CEREJEIRA et al, 2003;BAKER;SPETH, 1989 …”

Section: Introductionunclassified

Emprego do carvão ativado para remoção de atrazina em água de abastecimento público

Coelho¹,

Vazzoler

Leal

2012

Eng. Sanit. Ambient.

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ResumoA atrazina é um dos herbicidas mais utilizados no mundo, sendo encontrada em águas superficiais e subterrâneas. Pertence à classe das s-triazinas, possui potencial carcinogênico e apresenta toxicidade como disruptor endócrino. A reconhecida limitação dos processos de tratamento de água, os quais empregam a coagulação química na remoção da atrazina e os efeitos na saúde, motivou este trabalho, considerando a adsorção em carvão ativado como tecnologia alternativa. O estudo experimental consistiu na caracterização física do carvão ativado e nos ensaios de adsorção em águas de diferentes conteúdos orgânicos. Foi possível verificar a capacidade do carvão ativado em remover atrazina, e o mecanismo de adsorção foi influenciado pela variação da qualidade das matrizes de água gerando isotermas com características distintas.Palavras-chave: atrazina; carvão ativado; isotermas de adsorção; matéria orgânica natural. AbstractAtrazine is one of the most widely herbicides used in the world, being found in surface water and groundwater. It belongs to the s-triazines class classified as possible carcinogenic potential and toxicity presents as an endocrine disruptor. The acknowledged limitation of the water treatment processes, which employ chemical coagulation in atrazine removal and the risks to health, has motivated this work taking into regards the adsorption of activated carbon as an alternative technology. The experimental study consisted of physical characterization of activated carbon and of adsorption tests in waters of different organic content.It was possible to verify the capacity of activated carbon to remove atrazine, and the adsorption mechanism was influenced by the quality variation of water matrices generating isotherms with different characteristics.Keywords: atrazine; activated carbon; adsorption isotherms; natural organic matter.Endereço para correspondência: Edumar Ramos Cabral Coelho -Rua Alvim Borges da Silva, 168 -Jardim Camburí -29090-300 -E-mail: edumar@ct.ufes.br Recebido: 09/09/11 -Aceito: 28/01/13 -Reg. ABES: 39 IntroduçãoA aplicação de agrotóxicos na agricultura tem gerado grandes complicações ambientais como, por exemplo, a contaminação de mananciais destinados ao abastecimento público. Quando acumulados no corpo humano, mesmo em doses relativamente pequenas, os agrotóxicos podem produzir sérios efeitos sobre a saúde. Sendo assim, a produção de água potável requer o uso de tecnologias que proporcionem diminuição de matéria orgâ-nica e microcontaminantes para enquadramento ao padrão de potabilidade.A atrazina (ATZ) é um dos herbicidas mais utilizados no mundo e é caracterizada por sua abrangente aplicação, alta persistência em diferentes ambientes aquáticos, capacidade de produzir efeitos nos sistemas neuroendócrino e reprodutivo, além de ser classificada como de potencial carcinogênico (FRIEDMANN,

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Atrazine inhibition of testosterone production in rat males following peripubertal exposure

Cited by 178 publications

References 13 publications

Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)

Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

Emprego do carvão ativado para remoção de atrazina em água de abastecimento público

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