Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

Öksüz, Fatih; Yarlıoğlueş, Mikail; Öztürk, Serkan; Kaya, Fatma Duygu; Oksuz, Esra; Murat, Sani Namık; Turak, Osman; Çelik, İbrahim Etem; Kılıç, Alparslan; Kurtul, Alparslan

doi:10.5603/kp.a2017.0038

Cited by 7 publications

(2 citation statements)

References 23 publications

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“…A meta-analysis exhibited that AD has made a significant contribution to cardiac events, including an increased risk of cardiovascular mortality, coronary heart disease, and heart failure ( Emdin et al, 2016 ). Patients with AD have been identified to be characterized by prolonged atrial electromechanical delay detected by tissue Doppler echocardiography ( Oksuz et al, 2017 ), which was a herald of AF.…”

Section: Discussionmentioning

confidence: 99%

Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation

Ran

Zhang²,

Wan³

et al. 2022

Front. Pharmacol.

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Background: Anxiety disorder (AD) is the most common mental disorder, which is closely related to atrial fibrillation (AF) and is considered to be a trigger of AF. Pinocembrin has been demonstrated to perform a variety of neurological and cardiac protective effects through its anti-inflammatory and antioxidant activities. The current research aims to explore the antiarrhythmic effect of pinocembrin in anxiety disorder rats and its underlying mechanisms.Methods: 60 male Sprague-Dawley rats were distributed into four groups: CTL group: control rats + saline; CTP group: control rats + pinocembrin; Anxiety disorder group: anxiety disorder rats + saline; ADP group: anxiety disorder rats + pinocembrin. Empty bottle stimulation was conducted to induce anxiety disorder in rats for 3 weeks, and pinocembrin was injected through the tail vein for the last 2 weeks. Behavioral measurements, in vitro electrophysiological studies, biochemical assays, ELISA, Western blot and histological studies were performed to assess the efficacy of pinocembrin. In addition, HL-1 atrial cells were cultured in vitro to further verify the potential mechanism of pinocembrin.Results: After 3 weeks of empty bottle stimulation, pinocembrin significantly improved the exploration behaviors in anxiety disorder rats. Pinocembrin alleviated electrophysiological remodeling in anxiety disorder rats, including shortening the action potential duration (APD), prolonging the effective refractory period (ERP), increasing the expression of Kv1.5, Kv4.2 and Kv4.3, decreasing the expression of Cav1.2, and ultimately reducing the AF susceptibility. These effects may be attributed to the amelioration of autonomic remodeling and structural remodeling by pinocembrin, as well as the inhibition of oxidative stress with upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) pathway.Conclusion: Pinocembrin can reduce AF susceptibility in anxiety disorder rats induced by empty bottle stimulation, with the inhibition of autonomic remodeling, structural remodeling, and oxidative stress. Therefore, pinocembrin is a promising treatment for AF in patients with anxiety disorder.

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Section: Discussionmentioning

confidence: 99%

Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation

Ran

Zhang²,

Wan³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Thus, it might strengthen the data obtained in this valuable study. We thank Russo et al [1] for their interest in our article entitled "Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders" [2]. In our study, we investigated the atrial electromechanical delay (AEMD) by tissue Doppler imaging (TDI) echocardiography in patients suffering from generalised anxiety disorders, and found that this patient group has prolonged AEMD compared to healthy subjects.…”

mentioning

confidence: 89%

Atrial fibrillation risk evaluation in patients with generalised anxiety disorders: the role of electrocardiographic parameters. Commentary to the article: “Atrial electromechanical delay analysed by tissue Doppler echocardiography…"

et al. 2017

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We have read with great interest the recent article by Oksuz et al. [1] entitled "Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders". The authors showed prolonged intra-and inter-atrial electromechanical delay and increased P-wave dispersion in patients with anxiety disorders, and found a positive correlation between these abnormalities and the severity of the disease, assessed by Hamilton Anxiety Rating Scale. P-wave dispersion is considered to reflect the discontinuous and inhomogeneous propagation of sinus impulses and the prolongation of atrial conduction time, and it has been shown to be an independent risk factor for atrial fibrillation (AF) development [2]. Over many years, our research group has studied the electrocardiographic and echocardiographic indexes of AF risk in some other clinical conditions, such as obesity [3], beta-thalassemia major [4-7], congenital heart diseases [8], respiratory disease [9], and muscular dystrophies [10-12]. We showed that electrocardiogram (ECG) may be a feasible and low-cost method to early detect the presence of arrhythmogenic substrate and to identify the high-risk subgroup patients in need of careful electrocardiographic monitoring. Furthermore, it should be noted that in other clinical scenarios, P-wave parameters other than P-wave dispersion are risk predictors of supraventricular arrhythmias and notably of stroke [13-16], as reported in the literature. Specifically, we refer to interatrial block (IAB), which is defined as prolonged conduction time between right and left atria due to impulse delay or blockage, probably most often, but not exclusively, in Bachmann bundle, resulting in prolonged P-wave duration (≥ 120 ms), often with a bifid notch representing the electrical gap between the two-atrium activation. We suggest the authors to analyse IAB, taking the opportunity to firstly report the prevalence of IAB in patients with generalised anxiety disorders. The authors performed all electrocardiographic measurements manually. In our experience manual measurement

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Anxiety is associated with increased risk for atrial cardiopathy

et al. 2020

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Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

Cited by 7 publications

References 23 publications

Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation

Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation

Atrial fibrillation risk evaluation in patients with generalised anxiety disorders: the role of electrocardiographic parameters. Commentary to the article: “Atrial electromechanical delay analysed by tissue Doppler echocardiography…"

Anxiety is associated with increased risk for atrial cardiopathy

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