Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation

Ran, Qian; Zhang, Cui; Wan, Weiguo; Ye, Tianxin; Zou, Ying; Liu, Zhangchi; Yu, Yi; Zhang, Junhua; Shen, Bo; Yang, Bo

doi:10.3389/fphar.2022.1004888

Cited by 3 publications

(5 citation statements)

References 53 publications

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“…We recently demonstrated that the high incidence of AF in AD rats is associated with cardiac autonomic nerve remodeling and electrical remodeling. 15 This was again confirmed in this study, with substantial changes in atrial electrophysiology, including abnormal prolongation of APD and shortening of ERP. AF can be maintained by re-entry and/or focal ectopic trigger.…”

Section: Discussionsupporting

confidence: 83%

“…Consistent with previous studies, 15 a significant reduction in time-domain parameters, including average RR, SDRR, and RMSSD, was observed in AD rats compared with CTL rats (Figs. 3A-C).…”

Section: Inhibition Of Ampars Improved the Hrv In The Anxiety Disorde...supporting

confidence: 92%

“…SD rats were randomly divided into the following 6 groups: CTL group: control rats; AD group: anxiety disorder rats + saline; ADC group: anxiety disorder rats + CX546; ADN group: anxiety disorder rats + NBQX group; ADL group: anxiety disorder rats + LPS; and ADN + L group: anxiety disorder rats + NBQX + LPS. As mentioned above, 15 rats were allowed to drink water only at 9:00-9:10 and 21:00-21:10 every day during the first week to adjust to the new drinking habits. In the next 2 weeks, except for the CTL group, the rats in the remaining 3 groups were randomly given empty bottles once a day at 2 designated times.…”

Section: Rat Model Of Anxiety Disordermentioning

confidence: 99%

“…As previously described, 15,16 electrophysiological studies of the atrium were performed using a Langendorff apparatus. In brief, the heart was isolated and perfused with HEPES-buffered Tyrode's solution (mM NaCl 130, KCl 5.4, CaCl 2 1.8, MgCl 2 1, Na 2 HPO 4 0.3, HEPES 10, glucose 10, and pH adjusted to 7.4, with NaOH) equilibrated with a 95% O 2 /5% CO 2 gas mixture at 378C and at a constant pressure of 60 mm Hg.…”

Section: Electrophysiological Testingmentioning

confidence: 99%

“…14 Previous experiment showed that the induction rate of AF in GAD rats was significantly increased, which may be related to oxidative stress, inflammation, and cardiac remodeling. 15 Whether AMPARs play the role of AMPARs in anxiety-induced AF remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors Ameliorates Atrial Inflammation and Vulnerability to Atrial Fibrillation in Rats with Anxiety Disorders

Zou,

Liu,

et al. 2024

Journal of Cardiovascular Pharmacology

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Previous studies have found that anxiety disorders may increase the incidence of atrial fibrillation (AF). More and more studies have shown that AMPARs are involved in the occurrence and development of cardiovascular diseases. However, the role of AMPARs in AF associated with anxiety disorder remains unclear. The aim of this study was to investigate the effect of AMPARs on atrial fibrillation susceptibility in rats with anxiety disorder and its possible mechanism. The anxiety disorder rat model was established by unpredictable empty bottle stimulation, and was treated with AMPARs agonist and antagonist. Our results showed that AMPARs antagonist treatment significantly reduced sympathetic activity, improved heart rate variability, shortened action potential duration, prolonged effective refractory period, reduced AF induction rate, and improved cardiac electrical remodeling and the expression of inflammatory factors. In addition, inhibition of AMPARs reduced the phosphorylation of IκBα and p65. Our experimental results suggest that inhibition of AMPARs can reduce autonomic remodeling, improve atrial electrical remodeling and suppress myocardial inflammation, which provides a potential therapeutic strategy for the treatment of AF associated with anxiety disorder.

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Section: Discussionsupporting

confidence: 83%

“…Consistent with previous studies, 15 a significant reduction in time-domain parameters, including average RR, SDRR, and RMSSD, was observed in AD rats compared with CTL rats (Figs. 3A-C).…”

Section: Inhibition Of Ampars Improved the Hrv In The Anxiety Disorde...supporting

confidence: 92%

Section: Rat Model Of Anxiety Disordermentioning

confidence: 99%

Section: Electrophysiological Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhibition of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors Ameliorates Atrial Inflammation and Vulnerability to Atrial Fibrillation in Rats with Anxiety Disorders

Zou,

Liu,

et al. 2024

Journal of Cardiovascular Pharmacology

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The role and mechanism of heme oxygenase-1 in arrhythmias

Liu,

Zhang,

Yang

et al. 2024

J Mol Med

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Global epidemiology of mental disorder in atrial fibrillation between 1998-2021: A systematic review and meta-analysis

Zhang,

Liu

et al. 2024

World J Psychiatry

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BACKGROUND As the burden of mental disorders among patients with atrial fibrillation (AF) increases, researchers are beginning to pay close attention to the risk and prevalence of these comorbidities. Although studies have independently analyzed the risk of comorbidity with depression and anxiety in patients with AF, no study has systematically focused on the global epidemiology of these two mental disorders. AIM To explore the prevalence of depression and anxiety in patients with AF. METHODS Five databases were searched from their date of establishment until January 2023. Observational studies reporting the comorbidity of AF with depression and anxiety, were included in this study. Basic information, such as the first author/ publication year, study year, study type, and prevalence of depression and anxiety, were extracted. STATA SE 15.1 was used to analyze the data. Subgroup, meta-regression, and sensitivity analyses were performed to estimate study heterogeneity. RESULTS After a thorough search, 26 studies were identified and included in this meta-analysis. The prevalence rates of depression and anxiety in adults with AF were 24.3% and 14.5%, respectively. Among adult males with AF, the prevalence was 11.7% and 8.7%, respectively, whereas in females it was 19.8% and 10.1%, respectively. In older adults with AF, the prevalence rates of depression and anxiety were 40.3% and 33.6%, respectively. The highest regional prevalence of depression and anxiety was observed in European (30.2%) and North American (19.8%) patients with AF. CONCLUSION In this study, we found that the prevalence of depression and anxiety among patients with AF varies with sex, region, and evaluation scales, suggesting the need for psychological interventions for patients with AF in clinical practice.

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Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation

Cited by 3 publications

References 53 publications

Inhibition of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors Ameliorates Atrial Inflammation and Vulnerability to Atrial Fibrillation in Rats with Anxiety Disorders

Inhibition of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors Ameliorates Atrial Inflammation and Vulnerability to Atrial Fibrillation in Rats with Anxiety Disorders

The role and mechanism of heme oxygenase-1 in arrhythmias

Global epidemiology of mental disorder in atrial fibrillation between 1998-2021: A systematic review and meta-analysis

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