Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema

Abstract

These findings suggest that atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water and pulmonary arterial pressure, possibly independently from natriuresis/diuresis in oleic acid-induced pulmonary edema.

Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs

“…Because plasma half-lives (t 1/2 ) of ANP were 2.29 Ϯ 1.02 mins (␣-phase) and 15.2 Ϯ 4.75 mins (␤-phase) by the two-compartment model, respectively, the duration and the dose of ANP infusion (1 g/kg/min for 5 hrs) as used in this study seem to be sufficient to maintain its effective plasma concentrations. Although the lower dose (0.2 g/kg/min) of ANP in the rat ameliorated ischemic acute renal failure (10), the higher dose (1 g/kg/min) of ANP used in the present study was shown to cause the potent diuretic effect without affecting MAP in a dog model, as previously demonstrated in our laboratory (13). On the contrary, the gradual decrease in MAP after aortic clamp removal was not observed in the ANP group.…”

“…In humans, ANP infusion increased creatinine clearance and decreased the need for dialysis in patients with established acute renal failure (12). The use of a lower dose (0.2 g/kg/min) of ANP caused depressor effect in rats (10), whereas an even higher dose (1 g/kg/min) of ANP caused profound natriuretic-diuretic effects without depressor effect in dogs (13). Therefore, it is reasonable to consider that ANP may protect kidney from ischemic damage resulting from suprarenal abdominal aortic cross-clamping during aneurysm repair.…”

Differential Effects of Atrial Natriuretic Peptide on the Brain Water and Sodium after Experimental Cortical Contusion in the Rat

“…Recent evidence suggests that ANP reduces extravascular lung water in the dog model of oleic acid-induced pulmonary edema (Mitaka et al, 2002). This peptide also attenuated brain edema in the rat models of cerebral ischemia (Nakao et al, 1990;Naruse et al, 1991), intracerebral hemorrhage (Rosenberg and Estrada, 1995;Rosenberg et al, 1992), or induced hyponatremia (Vajda et al, 2001).…”

Post-ischemic Infusion of Atrial Natriuretic Peptide Attenuates Warm Ischemia–Reperfusion Injury in Rat Lung

“…14,15,20 In the lung, protective effects of ANP have been reported against chemical-, oxidant-and high-altitude-induced lung injuries. [23][24][25][26][27] So far, no investigation has shown a protective effect of ANP on I/R injury in lung.…”