Atropine Poisoning: Recovery After 7½ Grains of Atropine Sulphate by Mouth

Comroe, Bernard I.

doi:10.1001/jama.1933.27430310002009b

Cited by 14 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An oral dose of 10 mg of atropine would provoke moderate anticholinergic symptoms in most individuals: tachycardia, raised body temperature, reduced saliva production, mydriasis, disorientation, hallucinations, etc. . The lethal dose is between 100 and 200 mg, but quantities as low as 50 mg or even less than 5 mg in children have been linked with fatal cases .…”

Section: Discussionmentioning

confidence: 99%

“…The lethal dose is between 100 and 200 mg, but quantities as low as 50 mg or even less than 5 mg in children have been linked with fatal cases . On the other hand, cases have been reported of people surviving after ingesting doses of 500 mg to 1 g, but these patients often had the benefit of serious hospital care, with the possible administration of physostigmine or neostigmine as an antidote . It is noteworthy that the pharmacokinetics of atropine varies widely from one person to another.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Atropine Eye Drops: An Unusual Homicidal Poisoning

Carlier

Escard²,

Péoc’h³

et al. 2014

Journal of Forensic Sciences

View full text Add to dashboard Cite

In March 2009, the body of a 51-year-old man was found in the boot of his car. The body had been frozen before being dismembered at the abdomen. The autopsy failed to determine the cause of death. Systematic toxicological analyses of the victim's peripheral blood and urine showed the presence of atropine, a powerful anticholinergic. Atropine was therefore specifically detected and quantified throughout the victim's biologic samples by HPLC-MS² in the biologic fluids and UHPLC-MS² in the hair. The atropine concentrations were 887 ng/mL in the cardiac blood, 489 ng/mL in the peripheral blood, 6693 ng/mL in the gastric contents (1.1 μg), 6753 ng/mL in the urine, and 2290 pg/mg in the hair. The blood concentrations measured in the decedent were consistent with an overdose of atropine, which was determined as the cause of death. The manner of death was a homicide with criminal intent.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atropine Eye Drops: An Unusual Homicidal Poisoning

Carlier

Escard²,

Péoc’h³

et al. 2014

Journal of Forensic Sciences

View full text Add to dashboard Cite

show abstract

“…Chronic administration of atropine sulfate for 4 months resulted in paralytic ileus (274). The fatal dose is approximately 50 mg, but a patient who ingested 500 mg recovered after receiving intensive supportive care (276). The fatal dose is approximately 50 mg, but a patient who ingested 500 mg recovered after receiving intensive supportive care (276).…”

Section: Anticholinergic Drugsmentioning

confidence: 99%