Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept

Eriksson, Per; Lindskog, Cecilia; Lorente-Leal, Víctor; Waldenström, Jonas; González‐Acuña, Daniel; Järhult, Josef D.; Lundkvist, Åke; Olsén, Björn; Jourdain, Elsa; Ellström, Patrik

doi:10.3389/fmicb.2019.00815

Cited by 12 publications

(17 citation statements)

References 58 publications

(133 reference statements)

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“…Surface adhesion is achieved by binding HA to the cellular SA receptors. Although virus histochemistry only provides information about viral HA for host cell surface adhesion rather than replication ability of virus, it should be highlighted that viral HA for host cell surface adhesion is a necessary condition in the virus replication cycle [42]. In this study, the capacities of IAV bound with SA receptors in the airway of HBV-transgenic mice model and control mice were assessed, which showed that there were more H5N1 subtype strain virus and H1N1 vaccine binding to the trachea tissues from 14 to 16 or 18 month old HBV-transgenic mice compared with control mice significantly.…”

Section: Discussionmentioning

confidence: 99%

High expression levels of influenza virus receptors in airway of the HBV-transgenic mice

Yang

Jia

et al. 2019

Epidemiol. Infect.

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In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different α2-3- and α2-6-linked sialic acid (SA) binding preference. Only a few amino acid changes in the haemagglutinin on the surface of avian influenza viruses (AIV) can cause a switch from avian to human receptor specificity, and the individuals with pathognostic chronic diseases might be more susceptible to AIV due to the decreased expression level of terminal α2-3-linked SA in their saliva. Here, using lectin and virus histochemical staining, we observed the higher expression levels of α2-3/6-linked SA influenza virus receptors in the airway of HBV-transgenic mice compared with that of control mice due to the significant decrease in control mice during ageing, which imply that this is also a risk factor for individuals with pathognostic chronic diseases susceptible to influenza viruses. Our findings will help understand the impact on influenza virus pathogenesis and transmission.

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Section: Discussionmentioning

confidence: 99%

High expression levels of influenza virus receptors in airway of the HBV-transgenic mice

Yang

Jia

et al. 2019

Epidemiol. Infect.

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“…SA α2,3-Gal is the dominant receptor type in the intestines of these birds, and presence of both SAα2,3-Gal β(1-3)GalNAc and SAα2,3-Gal β(1-4)Glc NAc has been identified [ 21 ]. SA expression is reported to vary among various species of this order [ 66 ].…”

Section: Distribution Of Sialic Acid Receptors Among Multiple Hostmentioning

confidence: 99%

“…Of the type of SA α2,3-Gal receptors, SAα2,3-Gal β(1-4) GlcNAc receptors were reported to be dominant in these birds [ 21 ]. However, inter-species variations in the SA expression among the birds of this order have been reported [ 66 ].…”

Section: Distribution Of Sialic Acid Receptors Among Multiple Hostmentioning

confidence: 99%

Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus Spillover

Kuchipudi

Nelli

Gontu

et al. 2021

Viruses

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Emerging viral diseases are a major threat to global health, and nearly two-thirds of emerging human infectious diseases are zoonotic. Most of the human epidemics and pandemics were caused by the spillover of viruses from wild mammals. Viruses that infect humans and a wide range of animals have historically caused devastating epidemics and pandemics. An in-depth understanding of the mechanisms of viral emergence and zoonotic spillover is still lacking. Receptors are major determinants of host susceptibility to viruses. Animal species sharing host cell receptors that support the binding of multiple viruses can play a key role in virus spillover and the emergence of novel viruses and their variants. Sialic acids (SAs), which are linked to glycoproteins and ganglioside serve as receptors for several human and animal viruses. In particular, influenza and coronaviruses, which represent two of the most important zoonotic threats, use SAs as cellular entry receptors. This is a comprehensive review of our current knowledge of SA receptor distribution among animal species and the range of viruses that use SAs as receptors. SA receptor tropism and the predicted natural susceptibility to viruses can inform targeted surveillance of domestic and wild animals to prevent the future emergence of zoonotic viruses.

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“…It was important to investigate AIV attachment to trachea in many avian species [19]. AIVs mainly attached to α2,3-linked SA, but also to combinations of α2,3and α2,6-linked SA [20].…”

Section: Introductionmentioning

confidence: 99%

The molecular evolutionary characteristics of new isolated H9N2 AIV from East China and the function of vimentin on virus replication in MDCK cells

Zheng

Hao

et al. 2020

Virol J

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Background: The low pathogenic H9N2 AIV caused the serious impact on the poultry industry and public safety. Our purpose was to investigate the molecular evolutionary characteristics of the new isolated H9N2 virus and investigate the intracellular target protein of H9N2 AIV replication in sensitive cells. Methods: AIV A/chicken/Shandong/LY1/2017 (H9N2) was isolated from the cloaca of the healthy chicken in Shandong, and the full-length eight gene segments of this isolated H9N2 AIV were amplified by RT-PCR and analyzed. MDCK cells were used as the target cell model, and VOPBA assay and LC-MS/MS were carried out to identify the virus-binding protein of H9N2 AIV. MDCK cells were pre-treated with the special antibody and siRNA, and treated with H9N2 AIV to detect the virus replication. Additionally, Vimentin-pcDNA3.0 was successfully constructed, and transinfected into MDCK cells, and then H9N2 AIV mRNA was detected with RT-PCR. Results: Phylogenetic analysis revealed that HA, NA, PB2, PB1, PA, NP and M seven genes of the isolated H9N2 AIV were derived from A/Chicken/Shanghai/F/98, while NS gene was derived from A/Duck/Hong Kong/Y439/97. The cleavage site sequence of HA gene of the isolated H9N2 AIV was a PARSSR G pattern, and the left side sequence (224~229) of receptor binding site was NGQQGR pattern, which were similar to that of A/Chicken/Shanghai/F/98. Following VOPBA assay, we found one protein of about 50KDa binding to H9N2 AIV, and the results of LC-MS/MS analysis proved that vimentin was the vital protein binding to H9N2 AIV. The pre-incubation of the specific antibody and siRNA decreased the viral RNA level in MDCK cells treated with H9N2 AIV. Furthermore, we found that over-expressed vimentin increased H9N2 AIV replication in MDCK cells.

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Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept

Cited by 12 publications

References 58 publications

High expression levels of influenza virus receptors in airway of the HBV-transgenic mice

High expression levels of influenza virus receptors in airway of the HBV-transgenic mice

Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus Spillover

The molecular evolutionary characteristics of new isolated H9N2 AIV from East China and the function of vimentin on virus replication in MDCK cells

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