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Arora, Sheen J; Arora, Aman; Sangwan, Ritu; Jain, Prachi

doi:10.24327/ijrsr.2017.0803.0094

Cited by 11 publications

(13 citation statements)

References 1 publication

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“…They are mainly employed as medications, agrochemicals and as veterinary compounds and antioxidants. They are also find usefulness as sanitizers, developers, as corrosion inhibitors, as copolymers, dye stuff and etc [78] . Benzo[ a ]carbazoles 204 were prepared via sequential cyanide‐catalyzed imino Stetter reaction/Friedel‐Crafts reactions [32] .…”

Section: Application Of Stetter Reaction In Synthesis Of Heterocyclesmentioning

confidence: 99%

Recent Advances in Stetter Reaction and Related Chemistry: An update

et al. 2020

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The Stetter reaction is actually a special CÀ C bond forming reaction through a 1,4-addition reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes and Michael acceptors catalyzed by Nheterocyclic carbenes (NHC's) leading to preparation of 1,4dicarbonyl compounds via carbon-carbon bond formation. It offers a powerful approach to access 1,4-dicarbonyl compounds which are significant starting materials and inter-mediates in the synthesis of several heterocyclic systems, and bioactive heterocyclic framework which are present in natural products. In this review we try to underscore the recent advances in Stetter reaction and its applications from 2015 till date. Notably, we focused on the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products, which have largely been overlooked, previously.

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Section: Application Of Stetter Reaction In Synthesis Of Heterocyclesmentioning

confidence: 99%

Recent Advances in Stetter Reaction and Related Chemistry: An update

et al. 2020

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“…They also find applications as antioxidants, as corrosion inhibitors, and as copolymers. Various compounds of heterocyclic amides and thioethers are used in the field of biology, agriculture, optical material, and as intermediates in the synthesis of antibiotics, which would be very promising in the field of medicinal chemistry [1–3].…”

Section: Introductionmentioning

confidence: 99%

Convergent synthesis of carbonic anhydrase inhibiting bi‐heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

Khan

Abbasi

Aziz-Ur-Rehman

et al. 2021

Journal of Heterocyclic Chem

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By using a convergent methodology, a novel series of N‐arylated 4‐yl‐benzamides containing a bi‐heterocyclic thiazole–triazole core was synthesized, and the structures of these hybrid molecules, 9a–k, were corroborated through spectral analyses. The in vitro studies of these multifunctional molecules demonstrated their potent carbonic anhydrase inhibition relative to the standard used. The kinetics mechanism was exposed by Lineweaver–Burk plots, which revealed that 9j inhibited carbonic anhydrase non‐competitively by forming an enzyme‐inhibitor complex. The inhibition constants Ki calculated from Dixon plots for this compound was 1.2 μM. The computational study was also persuasive with the experimental results, and these molecules disclosed good results of all scoring functions and interactions, which suggested a good binding to carbonic anhydrase. So, it was predicted from the inferred results that these molecules might be considered as promising medicinal scaffolds for various diseases related to the uncontrolled production of this enzyme.

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“…Barbituric acid is a pyrimidine heterocyclic ring with an active methylene group that can be involved in condensation reactions with aldehydes, ketones and δ, β‐unsaturated carbonyl compounds forming other heterocycles compounds with an outstanding biological activity. Barbituric acid and its derivatives have been attracting considerable attention due to their wide range of pharmacological activities such as in‐vitro antitubercular and in‐vivo anticonvulsant, antibacterial, antiurease and antioxidant properties . On the other hand, the barbiturates possess several pharmacological applications, like anticancer, antituberculosis, antiviral, sedative, anxiolytic and urease inhibition and anti‐proliferative activities .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Pyrano[2,3‐d]pyrimidine‐2,4‐diones and Pyridino[2,3‐d]pyrimidine‐2,4,6,8‐tetraones: Evaluation Antitumor Activity

Haggam

Assy

Mohamed

et al. 2019

Journal of Heterocyclic Chem

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A series of some novel pyrano [2,3-d]pyrimidine 4-10 with 75-95% yields and pyridino[2,3-d]pyrimidine derivatives 11-16 with 75-92% yields is reported. The building structures have been achieved by reaction of 5-arylidene barbituric acid 2 and active nucleophile carbon or nitrogen as examples barbituric acid and acetyl acetone or refluxing of bispyrimidine-2,4,6-trione derivative 3 with cyclizing reagents such as phosphorous pentoxide, hydrazine hydrate and aminothiazole. The newly synthesized structures have been elucidated on the basis of their spectral analysis. Some selected members were screened for antitumor activity. Among the screened compounds 9, 16, 7, 10 and 8 exhibited high antitumor activity.

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Attachment retained overdenture

Cited by 11 publications

References 1 publication

Recent Advances in Stetter Reaction and Related Chemistry: An update

Recent Advances in Stetter Reaction and Related Chemistry: An update

Convergent synthesis of carbonic anhydrase inhibiting bi‐heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

Synthesis of Pyrano[2,3‐d]pyrimidine‐2,4‐diones and Pyridino[2,3‐d]pyrimidine‐2,4,6,8‐tetraones: Evaluation Antitumor Activity

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