Atteinte hépatique gravidique : mode de révélation d’une anomalie de la bêta-oxydation des acides gras chez l’enfant

Lamireau, Delphine; Feghali, H.; Redonnet‐Vernhet, Isabelle; Mesli, Samy; Carles, Dominique; Brissaud, Olivier

doi:10.1016/j.arcped.2011.12.020

Cited by 13 publications

(5 citation statements)

References 22 publications

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“…Deficient fatty acid oxidation in the offspring may lead to a severe fatty infiltration of fetal organs with fatal outcome [190,191]. To our knowledge, alterations in immunological parameters seem to be rare, if assessed at all.…”

Section: Immunological Backgroundmentioning

confidence: 83%

Immunology of hepatic diseases during pregnancy

2016

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The mother's immune system has to adapt to pregnancy accepting the semi-allograft fetus and preventing harmful effects to the developing child. Aberrations in feto-maternal immune adaptation may result in disease of the mother, such as liver injury. Five pregnancy-associated liver disorders have been described so far, however, little is known concerning immune alterations promoting the respective disease. These liver disorders are pre-eclampsia, hemolysis, elevated liver enzymes, low platelet count (HELLP), acute fatty liver, hyperemesis gravidarum, and intrahepatic cholestasis of pregnancy. On the other hand, pre-existing autoimmune liver injury of the mother can be affected by pregnancy. This review intends to summarize current knowledge linking feto-maternal immunology and liver inflammation with a special emphasis on novel potential biomarkers.

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Section: Immunological Backgroundmentioning

confidence: 83%

Immunology of hepatic diseases during pregnancy

2016

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“…Researchers have found that heredity, immunity, inflammation, metabolism, and blood coagulation have close relations with HELLP syndrome. 8,9 Many factors are intertwined and interact with each other, causing HELLP syndrome. The actual cause of HELLP syndrome is unknown and there is no targeted intervention for its pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of high-dose glucocorticoids on hemolysis, elevating liver enzymes, and reducing platelets syndrome

et al. 2018

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Objective To investigate the effectiveness of high-dose glucocorticoids on hemolysis, elevating liver enzymes, and reducing platelets (HELLP) syndrome. Methods A total of 151 patients with HELLP syndrome were analyzed and divided into two groups. Six subgroups of treatment and control groups were divided into three grades in accordance with the American Mississippi Diagnostic Criteria. Results There were no differences in general characteristics of the patients, primipara rate, minimum platelet recovery time, postpartum hemorrhage volume, postpartum hemorrhage rate, cumulative average of maternal damage, intensive care unit admission rate, perinatal mortality rate, and overall incidence rate of adverse outcomes in fetuses among the groups. The primipara rate in the control group of the third grade was significantly higher than that in the treatment group of the third grade. The treatment group of the second grade (88.7%) had a significantly higher preterm delivery rate than that in the control group of the second grade (66.7%). There were no differences in minimum hemoglobin, and maximum lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase levels among the groups and subgroups. Conclusion High-dose glucocorticoids cannot significantly improve maternal and fetal prognoses and laboratory indices. However, our results might offer some clinical evidence for HELLP syndrome therapy.

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“…Il faut savoir que le diagnostique différentiel le plus difficile de la SHAG est le HELLP syndrome car ils partagent de nombreuses similitudes dans les caractéristiques cliniques et biologiques. Les manifestations de la pré-éclampsie sont habituellement observées durant la deuxième moitié de la grossesse, alors que les symptômes de HELLP syndrome et la SHAG apparaissent fréquemment dans le troisième trimestre [2, 3]. L′incidence du HELLP syndrome est beaucoup plus élevé 1/5000 que celle de la SHAG 1/13000 [4].…”

Section: Discussionunclassified

“…La physiopathologie de la SHAG reste encore discutée, mais les études ont révélé une incidence plus élevée chez les femmes qui ont une mutation génétique qui affecte leur voie mitochondriale d'oxydation des acides gras et qui portent un fœtus avec carence d'une longue chaîne-3- hydroxyacyl-coenzyme A déshydrogénase [2, 7]. …”

Section: Discussionunclassified

Stéatose hépatique aiguë gravidique avec une pyélonéphrite aiguë droite sur une grossesse gémellaire: une association très rare

Benali¹,

Rachidi²,

Omari³

2013

Pan Afr Med J

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La Stéatose hépatique aiguë gravidique est une complication rare de la grossesse, et l'association avec la pyélonéphrite aiguë est encore plus rarissime survenant le plus souvent dans le troisième trimestre. Le diagnostic est affirmé par un faisceau d'argument clinique et biologique si non par l'histologie hépatique en dehors de trouble de la crase sanguine. Autrefois régulièrement mortelle, cette pathologie bénéficie actuellement d'un meilleur pronostic maternel et fœtal, du fait du diagnostic plus précoce, d'une délivrance rapide et du traitement symptomatique. Les auteurs ont jugé utile de rapporter une observation à travers d'un cas clinique d'une grossesse gémellaire associée à la pyélonéphrite aigue droite avec stéatose hépatique aiguë en milieu de réanimation.

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Atteinte hépatique gravidique : mode de révélation d’une anomalie de la bêta-oxydation des acides gras chez l’enfant

Cited by 13 publications

References 22 publications

Immunology of hepatic diseases during pregnancy

Immunology of hepatic diseases during pregnancy

Effectiveness of high-dose glucocorticoids on hemolysis, elevating liver enzymes, and reducing platelets syndrome

Stéatose hépatique aiguë gravidique avec une pyélonéphrite aiguë droite sur une grossesse gémellaire: une association très rare

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