Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers

Zhao, Zhong; Satsu, Hideo; Fujisawa, Masahiko; Hori, Masaru; Ishimoto, Yoko; Totsuka, Mamoru; Nambu, Aya; Kakuta, Shigeru; Ozaki, Hiroshi; Shimizu, Makoto

doi:10.1007/s00726-007-0562-8

Cited by 56 publications

(42 citation statements)

References 35 publications

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“…Taurine also significantly inhibited the increase in the expression of macrophage inflammatory protein (MIP-2), a pro-inflammatory chemokine. 89) These results suggest that taurine prevented DSSinduced colitis partly in association with its inhibitory effects on the secretion of MIP-2 from IECs and on the infiltration of inflammatory cells such as neutrophils. The cytoprotective functions of taurine in the epithelial barrier against the direct toxicity of DSS and inflammatory cell-induced injury were also suggested.…”

Section: Anti-inflammatory Functions Of Taurinementioning

confidence: 70%

“…To confirm the anti-inflammatory activity of taurine in experiments in vivo, the effects of dietary taurine on experimental colitis induced by dextran sulfate sodium (DSS) in C57BL/6 mice were investigated. 89) Taurine supplementation significantly attenuated the weight decrease, diarrhea severity, colon shortening, and the increase in colonic tissue myeloperoxidase activity induced by DSS. Taurine also significantly inhibited the increase in the expression of macrophage inflammatory protein (MIP-2), a pro-inflammatory chemokine.…”

Section: Anti-inflammatory Functions Of Taurinementioning

confidence: 90%

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Interaction between Food Substances and the Intestinal Epithelium

Shimizu

2010

Bioscience, Biotechnology, and Biochemistry

130

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The small intestine is an organ responsible for nutrient absorption, barrier functions, signal recognition/transduction, and the production of bioactive compounds. These functions are known to be regulated by such factors as hormones and cytokines, but substances contained in the daily diet are also thought to play roles as major modulators of intestinal functions. Intestinal epithelial cells (IECs), which form a monolayer covering the inside surface of the intestinal tract, are particularly important in this modulation, because they directly interact with intestinal contents, including food substances, their digests, and gut microbial components. Using cell-based in vitro assays, we investigated the food-IEC interactions at the cellular and molecular levels, and found that a variety of food substances affected the transporter activity, tight junction permeability, metabolic enzyme expression, immune functions, and so on. Modulation of the intestinal functions by dietary substances is therefore essential to promote health.

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Section: Anti-inflammatory Functions Of Taurinementioning

confidence: 70%

Section: Anti-inflammatory Functions Of Taurinementioning

confidence: 90%

Interaction between Food Substances and the Intestinal Epithelium

Shimizu

2010

Bioscience, Biotechnology, and Biochemistry

130

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“…Concerning taurine, in vitro data showed a protective role on enterocyte-like Caco-2 cell monolayer and a reduction of IL-8 release. 44 Prophylactic treatment with taurine in DSS-treated mice limited intestinal damage. 44 Interestingly, curative treatment with taurine also reduced the inflammatory response in TNBS-induced colitis, probably by increasing the defenses against oxidative insult.…”

Section: Other Amino Acidsmentioning

confidence: 99%

Potential for amino acids supplementation during inflammatory bowel diseases

Coëffier

Marion‐Letellier

Déchelotte

2010

Inflammatory Bowel Diseases

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The pathophysiology of inflammatory bowel diseases (IBDs) is multifactorial and involves interactions of gut luminal content with mucosal barrier and especially immune cells. Malnutrition is a frequent issue during IBD flares, especially in Crohn's disease (CD) patients, and nutritional support is frequently used to treat malnutrition but also in an attempt to modulate intestinal inflammation. The use of oral or enteral nutrition intervention in IBDs may be effective, alone or in combination with drugs, to achieve and maintain remission. However, standard diets are less effective than new-generation biotherapies and could be improved by supplementation with specific immunomodulatory amino acids. Experimental studies evaluating glutamine, the preferential substrate for enterocytes, are promising. Some clinical studies with oral glutamine in CD are until now disappointing, but new formulations and targeting could enhance glutamine efficacy at the site of mucosal lesions. The role of arginine, involved in nitric oxide and polyamines synthesis, still remains debated. However, the effects of these amino acids in IBD have been poorly documented in humans. Other candidates like glycine, cysteine, histidine, or taurine should also be evaluated in the future.

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“…It is therefore important to regulate and maintain the secretion of IL-8 by intestinal epithelial cells to prevent the intestinal inflammatory loop from developing. It has recently been discovered by using intestinal epithelial cell lines that such food components as flavonoids and amino acids suppressed stimulant-induced IL-8 secretion (12)(13)(14)(15). We focused the present study on the effect of food-derived components on stimulantinduced IL-8 production by intestinal epithelial cells.…”

mentioning

confidence: 99%

Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells

Satsu

Hyun

Shin

et al. 2009

J Nutr Sci Vitaminol

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SummaryThis study demonstrates the effect of soybean components on the tumor necrosis factor-␣ (TNF-␣ )-induced production of interleukin-8 (IL-8), one of the major inflammatory chemokines, in intestinal epithelial-like Caco-2 cells. Among the soybean components, an isoflavone fraction (IFF) suppressed the TNF-␣ -induced IL-8 secretion by Caco-2 cells in a dose-dependent manner, whereas a soyasaponin fraction and soypeptide fraction had no significant effect on TNF-␣ -induced IL-8 secretion. The IL-8 secretion induced by hydrogen peroxide and by IL-1 ␤ was not suppressed by IFF, suggesting that the inhibitory effect of isoflavone was specific for the TNF-␣ -induced regulation of IL-8. The increased expression of IL-8 mRNA by TNF-␣ was almost completely suppressed by IFF. Furthermore, the transcriptional activity of the human IL-8 promoter was increased by the TNF-␣ treatment, and IFF significantly suppressed the IL-8 promoter activity. These results indicate that IFF suppressed TNF-␣ -induced IL-8 production at the transcriptional level in human intestinal Caco-2 cells, suggesting IFF of soybean as a promising food component for preventing intestinal inflammation such as inflammatory bowel disease.

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Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers

Cited by 56 publications

References 35 publications

Interaction between Food Substances and the Intestinal Epithelium

Interaction between Food Substances and the Intestinal Epithelium

Potential for amino acids supplementation during inflammatory bowel diseases

Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells

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