Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells

Satsu, Hideo; Hyun, Ja Shil; Shin, Hee Soon; Shimizu, Makoto

doi:10.3177/jnsv.55.442

Cited by 20 publications

(8 citation statements)

References 22 publications

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“…The phytochemical chlorogenic acid (found in many agricultural products such as coffee and apples) and its metabolite caffeic acid have been shown to reduce the secretion of the proinflammatory cytokine IL8 in the human IECs caco2, when they were stimulated with TNFα and H 2 O 2 (Zhao et al, 2008). Similar results were found for isoflavone fractions in another study (Satsu et al, 2009). Chlorogenic acid was also observed to inhibit LPS induced cyclooxygenase-2 expression in mouse macrophage cells, by suppressing NFκβ activation (Shan et al, 2009).…”

Section: Dietary Phytochemicalssupporting

confidence: 90%

Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case

2014

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There are millions of microbes that live in the human gut. These are important in digestion as well as defense. The host immune system needs to be able to distinguish between the harmless bacteria and pathogens. The initial interaction between bacteria and the host happen through the pattern recognition receptors (PRRs). As these receptors are in direct contact with the external environment, this makes them important candidates for regulation by dietary components and therefore potential targets for therapy. In this review, we introduce some of the main PRRs including a cellular process known as autophagy, and how they function. Additionally we review dietary phytochemicals from plants which are believed to be beneficial for humans. The purpose of this review was to give a better understanding of how these components work in order to create better awareness on how they could be explored in the future.

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Section: Dietary Phytochemicalssupporting

confidence: 90%

Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case

2014

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“…16,17 Considering the findings that anti-inflammatory substances, such as component(s) of the Mediterranean diet, soybeans, and n-3 unsaturated fatty acid found in fish oil seem to inhibit age-associated diseases, then anti-inflammatory polyamines may have a role in inhibiting the progression of age-associated disease. [18][19][20][21][22] This is supported by our finding that mice having a long-term intake of chow with polyamine concentrations two to three times higher than that of soybeans had decreased age-associated pathologic changes and increased longevity. 23,24…”

Section: Introductionsupporting

confidence: 52%

Mediterranean diet and polyamine intake: possible contribution of increased polyamine intake to inhibition of age-associated disease

Binh¹,

Soda

Kawakami

2010

NDS

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The Mediterranean diet is a dietary pattern associated with increased longevity, and has been shown to have anti-inflammatory properties. Based on the findings that natural polyamines are strong anti-inflammatory substances, we have found that continuous and increased polyamine intake prolongs murine lifespan. Because polyamines are contained in most foods in widely varying concentrations, we sought epidemiologic evidence that supports an association between the Mediterranean diet and increased polyamine intake. The amounts of food supply in 49 European and other Western countries in 2005 were collected from the United Nations database, and the amount of food polyamine was estimated using polyamine concentrations in foods from published sources. The Mediterranean diet pattern was characteristically observed in Mediterranean countries. For all 49 countries and for foods such as olive oil (Spearman r = 0.602), fruit (r = 0.804), fruit and vegetables (r = 0.611), seafood (r = 0.461), and cheese (r = 0.411), the ratios of the amounts of these foods to total calories consumed were all positively associated (P , 0.05) with the amount of polyamine per calorie. Legumes per calorie (r = 0.379), wine per calorie (r = 0.285), and the amount of seafood and poultry meat relative to red meat (r = 0.313) had a trend of positive association with the amount of polyamine per calorie (P , 0.05), while several foods in the non-Mediterranean diet group had a trend of no or negative association. Food polyamines are absorbed quickly from the intestinal lumen, and long-term increased polyamine intake increases blood polyamine concentration. The present findings, together with previous studies on polyamines, indicate a possible role for the food polyamines that are abundant in the Mediterranean diet in prolonging human life.

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“…In IBD and colon cancer pathogenesis, IL-8 plays an important role in inducing the infiltration of neutrophiles and T cells into the intestinal mucosa (55,56). A number of studies demonstrated that treatment with 5-caffeoylquinic acid, caffeic acid and isoflavones effectively reduces the H 2 O 2 and TNF-α-induced IL-8 overproduction, as well as the overexpression of the IL-8 gene (57,58). In this study, we found that pretreatment with FME effectively attenuated the H 2 O 2 -induced IL-8 overproduction, and also reduced the mRNA expression of IL-8 in Caco-2 cells exposed to H 2 O 2 .…”

Section: Discussionmentioning

confidence: 99%

Effects of methanolic extract form Fuzhuan brick-tea on hydrogen peroxide-induced oxidative stress in human intestinal epithelial adenocarcinoma Caco-2 cells

Song

Gao

2014

Molecular Medicine Reports

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The present study investigated the protective effect of methanolic extract from Fuzhuan brick‑tea (FME) on hydrogen peroxide (H2O2)‑induced oxidative stress in the human intestinal epithelial adenocarcinoma cell line Caco‑2. Caco‑2 cells were pretreated with different concentrations (50, 100 and 200 µg/ml) of FME for 2 h and then exposed to H2O2 (1 mM) for 6 h. FME did not exhibit a significant cytotoxic effect and increased the cell viability following H2O2 treatment by decreasing lipid peroxidation in Caco‑2 cells. To investigate the protective effect of FME on H2O2‑induced oxidative stress in Caco‑2 cells, the levels of intracellular glutathione (GSH) and the activity of the endogenous antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH‑px) and glutathione S‑transferase (GST), were determined. FME significantly increased the level of GSH and the activity of antioxidant enzymes. The results from the present study demonstrated that FME has a protective effect on H2O2‑induced oxidative damage in Caco‑2 cells through the inhibition of lipid peroxidation and the increase in the activity of antioxidant enzymes. In addition, FME reduced the H2O2‑induced expression of interleukin‑8 at both the mRNA and protein levels in Caco‑2 cells.

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Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells

Cited by 20 publications

References 22 publications

Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case

Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case

Mediterranean diet and polyamine intake: possible contribution of increased polyamine intake to inhibition of age-associated disease

Effects of methanolic extract form Fuzhuan brick-tea on hydrogen peroxide-induced oxidative stress in human intestinal epithelial adenocarcinoma Caco-2 cells

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