Attenuation of Endothelial-Dependent Vasodilator Responses, Induced by Dye-Encapsulated Silica Nanoparticles, in Aortic Vessels

Farooq, Asima; Whitehead, Debra; Azzawi, May

doi:10.2217/nnm.12.213

Cited by 19 publications

(28 citation statements)

References 31 publications

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“…The ECs of the aortic vessels exposed to positively charged Si NPs (100 nm) exhibited a greater degree of attenuation of the vasodilator responses in vitro . Similar effects of dye‐encapsulated Si NPs on the aortic vessels were demonstrated by Farooq et al…”

Section: Bio‐toxicitysupporting

confidence: 74%

Bio‐effect of nanoparticles in the cardiovascular system

Hong

Zhang

2016

J Biomedical Materials Res

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Nanoparticles (NPs; < 100 nm) are increasingly being applied in various fields due to their unique physicochemical properties. The increase in human exposure to NPs has raised concerns regarding their health and safety profiles. The potential correlation between NP exposure and several cardiovascular (CV) events has been demonstrated. The aim of this review is to provide a comprehensive evaluation of the current knowledge regarding the bio-toxic impacts of titanium oxide, silver, silica, carbon black, carbon nanotube, and zinc oxide NPs exposure on the CV system in terms of in vivo and in vitro experiments, which is not fully understood presently. Moreover, the potential toxic mechanisms of NPs in the CV system that are still being questioned are elaborately discussed, and the underlying capacity of NPs used in medicine for CV events are summarized. It will be an important instrument to extrapolate relevant data for human CV risk evaluation and management. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2881-2897, 2016.

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Section: Bio‐toxicitysupporting

confidence: 74%

Bio‐effect of nanoparticles in the cardiovascular system

Hong

Zhang

2016

J Biomedical Materials Res

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“…The dosage of MNPs added to the aortic vessels was 1.96 Â 10 12 NP mL À1 was the same concentration used in our previous study in which we tested non-porous silica nanoparticles (71 ± 6 nm) [24]. In line with our previous observations with non-porous silica nanoparticles, the MNPs and FITC MNPs had no detriment to the endothelial-independent vasodilation indicating good biocompatibility.…”

Section: Time (Min)supporting

confidence: 58%

“…The difference between groups at a given concentration was tested by one way analysis of variance (ANOVA) with Bonferroni corrections. Statistical significance is taken as P < 0.05 as previously described by Farooq et al [24].…”

Section: Discussionmentioning

confidence: 99%

“…The aortic rings were placed under a constant 2 g tension throughout the experimentation as preliminary results have determined this to be the optimal tension value. Vessels were equilibrated for approximately 1 h, followed by pre-constriction with high K + (60 mM, KCl) to test vessel viability and achieve stable contraction, as previously described by Farooq et al [24]. Responses to SNP were examined by adding cumulative doses of SNP (0.01-100 lM) as a control.…”

Section: Vascular Functional Studiesmentioning

confidence: 99%

“…Ultrathin 70 nm sections were cut with Leica 'Ultracut S' ultramicrotome and placed on formvar carbon coated TEM copper grids (Agar Scientific). The samples were observed using a Tecnai 12 Biotwin TEM at 80 kV as previously described by Farooq et al [24].…”

Section: Transmission Electron Microscopymentioning

confidence: 99%

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Real-time observation of aortic vessel dilation through delivery of sodium nitroprusside via slow release mesoporous nanoparticles

Farooq

Tosheva

Azzawi

et al. 2016

Journal of Colloid and Interface Science

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Spherical mesoporous nanoparticles (MNPs) with a diameter of ∼100nm were synthesised via a sol-gel method in the presences of organic template (with and without fluorescein dye encapsulation). The template molecules were removed by acidic extraction to form a regular pore lattice structure. The nanoparticle size and morphology were analysed using transmission electron microscopy and dynamic light scattering analysis. The MNPs were further characterised by zeta potential, nitrogen adsorption measurements and infra-red spectroscopy. The interior pores had an average diameter of ∼3nm and were loaded with an endothelial-independent vasodilator, sodium nitroprusside (SNP). The optimal drug loading and drug release was determined in high potassium physiological salt solution using dialysis and atomic absorption spectroscopy. We demonstrate that the initial instantaneous release is due to the surface desorption of the drug followed by diffusion from the pores. Furthermore, these drug loaded MNPs (with and without fluorescein dye encapsulation) were added to viable aortic vessels and release in real-time was observed, ex vivo. MNPs and loaded with and without SNP were incubated with the vessel (at 1.96×10(12)NPmL(-1)) over a 3h time period. The real-time exposure to unloaded MNPs resulted in a small attenuation in constriction that occurred after approximately 1h. In contrast, MNPs loaded with SNP led to a rapid relaxation of aortic vessels that was sustained over the 3h period (p<0.001).

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Gallic Acid and Gallic Acid Nanoparticle Modulate Insulin Secretion Pancreatic β-Islets against Silica Nanoparticle–Induced Oxidative Damage

Ahangarpour

Sharifinasab

Kalantari‬

et al. 2022

Biol Trace Elem Res

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Attenuation of Endothelial-Dependent Vasodilator Responses, Induced by Dye-Encapsulated Silica Nanoparticles, in Aortic Vessels

Abstract: Our results suggest that the mechanism of attenuated dilation is different for SiNPs and silica RBITC nanoparticles, which has implications for the future fabrication of biocompatible nanoparticles for imaging diagnostics.

Cited by 19 publications

References 31 publications

Bio‐effect of nanoparticles in the cardiovascular system

Bio‐effect of nanoparticles in the cardiovascular system

Real-time observation of aortic vessel dilation through delivery of sodium nitroprusside via slow release mesoporous nanoparticles

Gallic Acid and Gallic Acid Nanoparticle Modulate Insulin Secretion Pancreatic β-Islets against Silica Nanoparticle–Induced Oxidative Damage

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