Gallic Acid and Gallic Acid Nanoparticle Modulate Insulin Secretion Pancreatic β-Islets against Silica Nanoparticle–Induced Oxidative Damage

Ahangarpour, Akram; Sharifinasab, Hassan; Kalantari‬, Heibatullah; Dehghani, Mohammad Amin; Maram, Nader Shakiba; Golfakhrabadi, Fereshteh

doi:10.1007/s12011-022-03111-y

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…Researchers in various fields have explored different nanoparticles loaded with GA, including poly(lactic-co-glycolic acid) (PLGA) nanoparticles, 33 chitosan nanoparticles, 34 and Silica Nanoparticles. 35 Our findings indicated that the stable release of GA led to a significant decrease in intracellular ROS levels, which also reduced cardiomyocyte apoptosis ( Figures 6 and 7B ).…”

Section: Discussionsupporting

confidence: 55%

“…Mg 2+ has been demonstrated to promote cell proliferation and angiogenesis. [33][34][35] Apart from enhancing HUVEC proliferation, magnesium ions also impact multiple-signaling pathways to induce growth factor secretion, such as PDGF and VEGF. 36 Increased secretion of PDGF and VEGF promotes significant endothelial cell proliferation, creating a positive feedback loop.…”

Section: Discussionmentioning

confidence: 99%

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Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells

Yu,

Ding,

Chen

et al. 2024

IJN

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Introduction Excessive generation of reactive oxygen species (ROS) following myocardial ischemia-reperfusion (I/R) can result in additional death of myocardial cells. The rapid clearance of ROS after reperfusion injury and intervention during subsequent cardiac repair stages are crucial for the ultimate recovery of cardiac function. Methods Magnesium-doped mesoporous bioactive glasses were prepared and loaded with the antioxidant drug gallic acid into MgNPs by sol-gel method. The antioxidant effects of MgNPs/GA were tested for their pro-angiogenic and anti-inflammatory effects based on the release characteristics of GA and Mg 2+ from MgNPs/GA. Later, we confirmed in our in vivo tests through immunofluorescence staining of tissue sections at various time points that MgNPs/GA exhibited initial antioxidant effects and had both pro-angiogenic and anti-inflammatory effects during the cardiac repair phase. Finally, we evaluated the cardiac function in mice treated with MgNPs/GA. Results We provide evidence that GA released by MgNPs/GA can effectively eliminate ROS in the early stage, decreasing myocardial cell apoptosis. During the subsequent cardiac repair phase, the gradual release of Mg 2+ from MgNPs/GA stimulated angiogenesis and promoted M2 macrophage polarization, thereby reducing the release of inflammatory factors. Conclusion MgNPs/GA acting on multiple cell types is an integrated solution for comprehensive attenuation of myocardial ischaemia-reperfusion injury and cardiac function protection.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells

Yu,

Ding,

Chen

et al. 2024

IJN

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“…The antioxidant activity of the hydrogels in the presence of ROS was determined by measuring the intracellular total SOD, GSH, MDA, [ 50 ] and ROS. The cells were cultured with the hydrogel extract for 24 h and induced with 500 × 10 −6 m H 2 O 2 for 12 h. First, the cells were collected with PBS at 4 °C and air‐conditioned.…”

Section: Methodsmentioning

confidence: 99%

Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing

Zan,

Yang,

Xiao

et al. 2023

Advanced Science

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Treating the most widespread complication of diabetes: diabetic wounds poses a significant clinical obstacle due to the intricate nature of wound healing in individuals with diabetes. Here a novel approach is proposed using easily applicable injectable gelatin/metal/tea polyphenol double nanonetworks, which effectively remodel the wound microenvironment and accelerates the healing process. The gelatin(Gel) crosslink with metal ions (Zr4+) through the amino acids, imparting advantageous mechanical properties like self‐healing, injectability, and adhesion. The nanonetwork's biological functions are further enhanced by incorporating the tea polyphenol metal nanonetwork through in situ doping of the epigallocatechin gallate (EGCG) with great antibacterial, self‐healing, antioxidant, and anticancer capabilities. The in vitro and in vivo tests show that this double nanonetworks hydrogel exhibits faster cell migration and favorable anti‐inflammatory and antioxidant properties and can greatly reshape the microenvironment of diabetic wounds and accelerate the wound healing rate. In addition, this hydrogel is completely degraded after subcutaneous injection for 7 days, with nondetectable cytotoxicity in H&E staining of major mice organs and the serum level of liver function indicators. Considering the above‐mentioned merits of this hydrogel, it is believed that the injectable gelatin/metal/tea polyphenol double nanonetworks have broad biomedical potential, especially in diabetic wound repair and tissue engineering.

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“…191 GA has many biological activities, including anti-inflammatory, anti-tumor, immunomodulatory, hypoglycemic, and hyperlipidemic. 192 GA has strong antioxidant activity due to its three hydroxyl groups. 193 A schematic diagram of the multifunctional MOF magnesium microneedle patch prepared with gallic acid and Mg 2+ is shown in Fig.…”

Section: Delivering Drugs For Regulating Inflammationmentioning

confidence: 99%

Smart microneedle patches for wound healing and management

Gao

Liu

et al. 2023

J. Mater. Chem. B

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Gallic Acid and Gallic Acid Nanoparticle Modulate Insulin Secretion Pancreatic β-Islets against Silica Nanoparticle–Induced Oxidative Damage

Cited by 5 publications

References 44 publications

Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells

Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells

Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing

Smart microneedle patches for wound healing and management

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