Attenuation of renal ischemia-reperfusion injury by trimetazidine:
Evidence of an in vivo antioxidant effect

Kaur, Harsimran; Padi, S.S.V.; Chopra, Kirti

doi:10.1358/mf.2003.25.10.793329

Cited by 16 publications

(19 citation statements)

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“…In this context, the antioxidant role of TMZ in the renal I/R injury has been investigated by administering it in vivo or by adding it to preservation solutions used for kidney transplantation [5,[10][11][12] . In addition, it has been suggested that TMZ can prevent the injury of the kidney as a remote organ by diminishing systemic oxidative stress in the body in the situations of I/R elsewhere [13] .…”

Section: Effectiveness Of Trimetazidine In Testicular Torsionmentioning

confidence: 99%

Protective Effects of Trimetazidine on Testicular Ischemia-Reperfusion Injury in Rats

Unal

Karataş

Savaş³

et al. 2007

Urol Int

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Introduction: We tried to prove the effectiveness of trimetazidine (TMZ) on testicular torsion-detorsion injury. Materials and Methods: 15 male rats were equally divided into three groups: group 1 was the sham-operated control group; group 2 had 2 h of unilateral testicular ischemia followed by 3 days of reperfusion, and group 3 had 2 h of unilateral testicular ischemia followed by 3 days of oral TMZ treatment (5 mg/kg, bid) during reperfusion. In the removed testicles, tissue reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), malondialdehyde (MDA) levels and pathological modified Johnson scores (MJS) were evaluated. Mann-Whitney U test was used for statistical evaluations. Results: In group 2, on the ipsilateral side, GSH were significantly lower and MDA were higher than in groups 1 and 3, though GSH and MDA were not statistically different between groups 1 and 3. On the other hand, GPx in the control testicles of group 3 was significantly lower compared to those in the counterparts of both groups 1 and 2. Among three groups, GR determined in both testicles were not statistically different. On the ipsilateral side, MJS in group 3 were lower than in the sham group, but significantly higher than in group 2. Conclusions: According to this study, TMZ has an antioxidant effect on testicular torsion-detorsion injury, though the protective effect of TMZ seems to decrease in control testicles. Consequently it has been considered that TMZ can be only used in torsion patients with a healthy contralateral testicle after further studies have been conducted.

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Section: Effectiveness Of Trimetazidine In Testicular Torsionmentioning

confidence: 99%

Protective Effects of Trimetazidine on Testicular Ischemia-Reperfusion Injury in Rats

Unal

Karataş

Savaş³

et al. 2007

Urol Int

View full text Add to dashboard Cite

show abstract

“…Several studies in animal models provide evidence for the utility of antioxidants in protecting endothelial cells and other cells in the kidney, and reducing I/Rmediated renal tissue damage [12][13][14][15]. At present, however, antioxidant drugs have not been approved for renal I/R injury in patients.…”

Section: Introductionmentioning

confidence: 99%

ETS-GS, a New Antioxidant, Ameliorates Renal Ischemia-Reperfusion Injury in a Rodent Model

Hagiwara

Koga

Iwasaka

et al. 2011

Journal of Surgical Research

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“…Recipient treatment with trimetazidine improved graft function and protected energy status after lung transplantation (Inci et al, 2001). The effects of trimetazidine in a rat model of renal ischemia-reperfusion injury were investigated (Kaur et al, 2003). The ischemic kidneys of rats showed severe hyaline casts, epithelial swelling, proteinaceous debris, tubular necrosis, medullary congestion and hemorrhage.…”

Section: Effect Of Trimetazidine On the Nucleotide Profile In Rat Kidmentioning

confidence: 99%

Ischemia-Reperfusion Injury in the Transplanted Kidney Based on Purine Metabolism Markers and Activity of the Antioxidant System

Domański¹,

Kłoda²,

Ciechanowski³

2012

Organ Donation and Transplantation - Public Policy and Clinical Perspectives

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Attenuation of renal ischemia-reperfusion injury by trimetazidine: Evidence of an in vivo antioxidant effect

Cited by 16 publications

References 0 publications

Protective Effects of Trimetazidine on Testicular Ischemia-Reperfusion Injury in Rats

Protective Effects of Trimetazidine on Testicular Ischemia-Reperfusion Injury in Rats

ETS-GS, a New Antioxidant, Ameliorates Renal Ischemia-Reperfusion Injury in a Rodent Model

Ischemia-Reperfusion Injury in the Transplanted Kidney Based on Purine Metabolism Markers and Activity of the Antioxidant System

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