2022
DOI: 10.1155/2022/6551358
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Attenuation of Some Inflammatory Markers by Endurance Training in the Spinal Cord of Rats with Diabetic Neuropathic Pain

Abstract: Nervous inflammation is an important component of the pathogenesis of neurodegenerative diseases including chronic diabetic neuropathic pain. In order to obtain a decrease in the progression of diabetic neuronal damage, it may be necessary to examine therapeutic options that involve antioxidants and anti-inflammatory agents. The aim of this study was to investigate the attenuation of inflammatory factors with endurance training in the spinal cord of rats with neuropathic pain. Thirty-two 8-week-old male Wistar… Show more

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Cited by 3 publications
(2 citation statements)
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“…It was found that both HIIT and MCT owned favorable adaptability to IL‐6, but only HIIT group could improve the blood lipid status of DM patients 267 . Previous data showed endurance training significantly decreased the gene expression of NLRP3, P38MAPK, TNF‐α, and IL‐1β in the spinal cord of DM rats 268 . Therefore, exercise played a pivotal role in improving the level of NLRP3 inflammasome and its related inflammatory factors.…”
Section: Therapeutic Interventions Targeting Inflammation In Diabetesmentioning
confidence: 93%
See 1 more Smart Citation
“…It was found that both HIIT and MCT owned favorable adaptability to IL‐6, but only HIIT group could improve the blood lipid status of DM patients 267 . Previous data showed endurance training significantly decreased the gene expression of NLRP3, P38MAPK, TNF‐α, and IL‐1β in the spinal cord of DM rats 268 . Therefore, exercise played a pivotal role in improving the level of NLRP3 inflammasome and its related inflammatory factors.…”
Section: Therapeutic Interventions Targeting Inflammation In Diabetesmentioning
confidence: 93%
“…267 Previous data showed endurance training significantly decreased the gene expression of NLRP3, P38MAPK, TNF-α, and IL-1β in the spinal cord of DM rats. 268 Therefore, exercise played a pivotal role in improving the level of NLRP3 inflammasome and its related inflammatory factors. In future, it is worth to study the effects of exercise type, intensity and duration on DM patients.…”
Section: Healthy Diet and Exercisementioning
confidence: 99%