This paper investigates the fixed-time attitude tracking control problem for flexible spacecraft with unknown bounded disturbances. First, with the knowledge of norm upper bounds of external disturbances and the coupling effect of flexible modes, a novel robust fixed-time controller is designed to deal with this problem. Second, the controller is further enhanced by an adaptive law to avoid the knowledge of norm upper bounds of external disturbances and coupling effect of flexible modes. This control law guarantees the convergence of attitude tracking errors in fixed time where the settling time is bounded by a constant independent of initial conditions. Moreover, the proposed controllers can prevent the unwinding phenomenon. Simulation results are presented to demonstrate the performance of the proposed control scheme.