Atypical presentation of syphilitic uveitis associated with Kyrieleis plaques

Superficial Retinal Precipitates in Patients With Syphilitic Retinitis

“…One eye developed nodular periarteritis also known as Kyrieleis plaques. 23 On fluorescein angiogram, the superficial retinal precipitates showed early blockage with no evidence of late leakage or staining.…”

Kyrieleis plaques in herpes zoster virus-associated acute retinal necrosis: a case report

“…2 Other described associated causes include cytomegalovirus (CMV) retinitis, syphilitic retinitis, acute retinal necrosis (ARN) due to Herpes Simplex Virus-2, Varicella-Zoster Virus, and Rickettsia conorii infections. [3][4][5] Orzalesi and Ricciardi 6 suggested they are an immune response, resulting from deposition of immune cells and inflammatory debris in arterial walls. Others have debated this hypothesis as these plaques can persist despite resolution of the infection and treatment with steroids.…”

“…3 Previous retrospective case series of MPS I patients without defined genotype treated with ERT have not shown significant improvement in vision, corneal, or optic nerve changes. 4,5 Little is known about genotype-ocular phenotype correlation in MPS I, but it may be expected that a series of patients with a single L490P mutation would have less ocular phenotypic variability than a group of patients with a variety of mutations. This case series demonstrates that the severity of corneal haze at final follow-up correlated with the timing of treatment with either ERT or HSCT (Figure 1a), although children treated earlier were younger at follow-up ( Table 1).…”

Kyrieleis Plaques Associated With Acute Retinal Necrosis From Herpes Simplex Virus Type 2

“…Kyrieleis initially described periarterial deposits in association with ocular tuberculosis. 14 Subsequently, Kyrieleis plaques have been described in association with toxoplasmosis, 20 syphilis, 16,21 Mediterranean spotted fever, 22 herpes zoster virus-associated ARN syndrome, 23 intraocular lymphoma, 24 arterial macroaneurysms, 23 and associated with collagen vascular disease. 25 The underlying etiology of Kyrieleis plaques may determine the potential for these plaques to present bilaterally.…”