Au<sub>3</sub>Cu tetrapod nanocrystals: highly efficient and metabolizable multimodality imaging-guided NIR-II photothermal agents

Wang, Zhiyi; Ju, Yanmin; Tong, Shiyan; Zhang, Hongchen; Lin, Jian; Wang, Baodui; Hou, Yanglong

doi:10.1039/c8nh00135a

Cited by 25 publications

(27 citation statements)

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“…e) Calculation of the photothermal conversion efficiency at 1064 nm. f) Comparison of photothermal conversion efficiency (η) of reported PTT agents in the NIR‐II biowindow: 1) AuNCs@SiO 2 ; 2) Au 3 Cu@PEG TPNCs; [ 46 ] 3) Au‐wires‐on‐AuNR; [ 47 ] 4) Pt Spiral; [ 48 ] 5) Cu 2 MnS 2 NPs; [ 49 ] 6) Nb 2 C (Mxene); [ 50 ] 7) Cu 3 BiS 3 NRs; [ 51 ] 8) L‐Pdots; [ 52 ] 9) TBDOPV‐DT NPs; [ 53 ] 10) SPN‐DT. [ 54 ] g) Relative viabilities of 4T1 cells after co‐incubation with different concentrations of AuNCs@SiO 2 under different 1064 nm laser treatment (0.5 W cm −2 ).…”

Section: Methodsmentioning

confidence: 99%

Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

et al. 2020

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Precise manipulation of optical properties through the structure‐evolution of plasmonic nanoparticles is of great interest in biomedical fields including bioimaging and phototherapy. However, previous success has been limited to fixed assembled structures or visible–NIR‐I absorption. Here, an activatable NIR‐II plasmonic theranostics system based on silica‐encapsulated self‐assembled gold nanochains (AuNCs@SiO2) for accurate tumor diagnosis and effective treatment is reported. This transformable chain structure breaks through the traditional molecular imaging window, whose absorption can be redshifted from the visible to the NIR‐II region owing to the fusion between adjacent gold nanoparticles in the restricted local space of AuNCs@SiO2 triggered by the high H2O2 level in the tumor microenvironment (TME), leading to the generation of a new string‐like structure with strong NIR‐II absorption, which is further confirmed by finite‐difference‐time‐domain (FDTD) simulation. With the TME‐activated characteristics, AuNCs@SiO2 exhibits excellent properties for photoacoustic imaging and a high photothermal conversion efficiency of 82.2% at 1064 nm leading to severe cell death and remarkable tumor growth inhibition in vivo. These prominent intelligent TME‐responsive features of AuNCs@SiO2 may open up a new avenue to explore optical regulated nano‐platform for intelligent, accurate, and noninvasive theranostics in NIR‐II window.

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Section: Methodsmentioning

confidence: 99%

Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

et al. 2020

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“…For example, the hypoxia tumor microenvironment (TME) deteriorates the PDT efficiency and the heat shock response weakens the PTT effect. [16][17][18][19][20][21][22][23][24][25][26] As an emerging therapeutic strategy, the fundamental mechanism of chemodynamic therapy (CDT) involves the generation of highly toxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O 2 ) catalyzed by transition metal, metal, or peroxidase-like catalysts through in situ treatment. [27][28][29][30][31][32][33][34] If the Fenton or Fenton-like reactions can simultaneously produce oxygen (O 2 ) along with •OH, the generated O 2 may also relieve TME hypoxia and enhance the therapeutic efficacy of PDT simultaneously.…”

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confidence: 99%

An Ultrasmall SnFe₂O₄ Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

Feng

Liu

Xie

et al. 2020

Adv Funct Materials

182

138

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The tumor microenvironment (TME) with the characteristics of severe hypoxia, overexpressed glutathione (GSH), and high levels of hydrogen peroxide (H2O2) dramatically limits the antitumor efficiency by monotherapy. Herein, a novel TME‐modulated nanozyme employing tin ferrite (SnFe2O4, abbreviated as SFO) is presented for simultaneous photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The as‐fabricated SFO nanozyme demonstrates both catalase‐like and GSH peroxidase‐like activities. In the TME, the activation of H2O2 leads to the generation of hydroxyl radicals (•OH) in situ for CDT and the consumption of GSH to relieve antioxidant capability of the tumors. Meanwhile, the nanozyme can catalyze H2O2 to generate oxygen to meliorate the tumor hypoxia, which is beneficial to achieve better PDT. Furthermore, the SFO nanozyme irradiated with 808 nm laser displays a prominent phototherapeutic effect on account of the enhanced photothermal conversion efficiency (η = 42.3%) and highly toxic free radical production performance. This “all in one” nanozyme integrated with multiple treatment modalities, computed tomography, and magnetic resonance imaging properties, and persistent modulation of TME exhibits excellent tumor theranostic performance. This strategy may provide a new dimension for the design of other TME‐based anticancer strategies.

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“…Subsequently, we further evaluated the nanozyme activity of Ag 2 S@Fe 2 CDSPE PEGiRGD in cancer cells. Because nonfluorescent dihydrorhodamine 123 (DHR123) can be oxidized by ROS into green fluorescent rhodamine 123, DHR123 was used as an intracellular ROS indicator (36). Fortunately, the strongest fluorescence intensity was shown in the group of Ag 2 S@Fe 2 CDSPEPEGiRGD under the ir radiation of 808nm laser, which demonstrated that the nanozyme (Fig.…”

Section: Evaluation Of Enhanced Cellular Uptake Ros-generation and mentioning

confidence: 95%

Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer

et al. 2020

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Nanozymes as artificial enzymes that mimicked natural enzyme–like activities have received great attention in cancer therapy. However, it remains a great challenge to design nanozymes that precisely exert its activity in tumor without producing off-target toxicity to surrounding normal tissues. Here, we report a synergetic enhancement strategy through the combination between nanozyme and tumor vascular normalization to destruct tumors, which was based on tumor microenvironment (TME) “unlocking.” This nanozyme that we developed not only has photothermal properties but also can produce reactive oxygen species efficiently under the stimulation of TME. Moreover, this nanozyme also showed remarkable imaging performance in fluorescence imaging in the second near-infrared region and magnetic resonance imaging for visualization tracing in vivo. The process of combination therapy showed remarkable therapeutic effect for breast cancer. This study provides a therapeutic strategy by the cooperation between multifunctional nanozyme and tumor vascular normalization for intensive combination therapy of breast cancer.

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Au₃Cu tetrapod nanocrystals: highly efficient and metabolizable multimodality imaging-guided NIR-II photothermal agents

Abstract: Au3Cu tetrapod nanocrystals were synthesized. After surface modification, the obtained monodisperse Au3Cu@PEG-Cy5,FA showed great potential as a fluorescence imaging and MSOT imaging-guided photothermal agent in the NIR-II region, which could be metabolized in vitro after treatment.

Cited by 25 publications

References 55 publications

Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

An Ultrasmall SnFe₂O₄ Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer

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Au3Cu tetrapod nanocrystals: highly efficient and metabolizable multimodality imaging-guided NIR-II photothermal agents

Abstract: Au3Cu tetrapod nanocrystals were synthesized. After surface modification, the obtained monodisperse Au3Cu@PEG-Cy5,FA showed great potential as a fluorescence imaging and MSOT imaging-guided photothermal agent in the NIR-II region, which could be metabolized in vitro after treatment.

Cited by 25 publications

References 55 publications

Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

Activatable NIR‐II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

An Ultrasmall SnFe2O4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer

Contact Info

Product

Resources

About

Au₃Cu tetrapod nanocrystals: highly efficient and metabolizable multimodality imaging-guided NIR-II photothermal agents

An Ultrasmall SnFe₂O₄ Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy