Au-ultrathin functionalized core–shell (Fe3O4@Au) monodispersed nanocubes for a combination of magnetic/plasmonic photothermal cancer cell killing

Abdulla-Al-Mamun, Md.; Kusumoto, Yoshihumi; Zannat, Tohfatul; Horie, Yuji; Manaka, Hirotaka

doi:10.1039/c3ra21479f

Cited by 50 publications

(34 citation statements)

References 33 publications

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“…XRD was used to identify the crystalline structure of all samples. As can be seen in Figure 2B, the bare Fe3O4 exhibited characteristic crystalline peaks at around 30.40°, 35.80°, 43.60°, 53.70°, 57.20° and 62.70°, which are consistent with the standard Fe3O4 XRD data (JCPDS, card 89-0950) [46]. In addition, it was found ( Figure 2B(c)) that the coating procedure did not affect the phase change of Fe3O4 nanoparticles because the SiO2 and APTES coatings are amorphous.…”

Section: Preparation and Characterization Of The Magnetic Combi-cleassupporting

confidence: 80%

Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes In Situ

et al. 2018

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Enzymes are biocatalysts. In this study, a novel biocatalyst consisting of magnetic combined cross-linked enzyme aggregates (combi-CLEAs) of 3-quinuclidinone reductase (QNR) and glucose dehydrogenase (GDH) for enantioselective synthesis of (R)-3-quinuclidinolwith regeneration of cofactors in situ was developed. The magnetic combi-CLEAs were fabricated with the use of ammonium sulfate as a precipitant and glutaraldehyde as a cross-linker for direct immobilization of QNR and GDH from E. coli BL(21) cell lysates onto amino-functionalized Fe 3 O 4 nanoparticles. The physicochemical properties of the magnetic combi-CLEAs were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and magnetic measurements. Field emission scanning electron microscope (FE-SEM) images revealed a spherical structure with numerous pores which facilitate the movement of the substrates and coenzymes. Moreover, the magnetic combi-CLEAs exhibited improved operational and thermal stability, enhanced catalytic performance for transformation of 3-quinuclidinone (33 g/L) into (R)-3-quinuclidinol in 100% conversion yield and 100% enantiomeric excess (ee) after 3 h of reaction. The activity of the biocatalysts was preserved about 80% after 70 days storage and retained more than 40% of its initial activity after ten cycles. These results demonstrated that the magnetic combi-CLEAs, as cost-effective and environmentally friendly biocatalysts, were suitable for application in synthesis of (R)-3-quinuclidinol essential for the production of solifenacin and aclidinium with better performance than those currently available.

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Section: Preparation and Characterization Of The Magnetic Combi-cleassupporting

confidence: 80%

Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes In Situ

et al. 2018

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“…Copyright 2011, American Chemical Society; d) Reproduced with permission . Copyright 2006, American Chemical Society; e) Reproduced with permission . Copyright 2013, Royal Society of Chemistry; f) Reproduced with permission .…”

Section: Preparation Of (Plasmonic Metal)/semiconductor Hybrid Nanostmentioning

confidence: 99%

“…In silica‐cored Au nanoshells, the silica nanosphere core mainly functions as a structural template. Effort has been made to replace silica nanosphere cores with semiconductors in order to obtain bifunctional nanostructures . However, so far there have been only a few successes, because the coating of a continuous metal shell requires the surface functionalization of the core.…”

Section: Preparation Of (Plasmonic Metal)/semiconductor Hybrid Nanostmentioning

confidence: 99%

“…The attached Au nanoparticles act as nucleation sites for further Au deposition, which causes gradual formation of a continuous Au shell. (Fe 3 O 4 core)/(Au shell) nanostructures have also been made by electrostatic adsorption and subsequent reduction of [AuCl 4 ] − species on Fe 3 O 4 nanocubes (Figure e) . The adsorption is realized by surface‐functionalizing Fe 3 O 4 nanocubes with poly‐L‐histidine to make their surface positively charged.…”

Section: Preparation Of (Plasmonic Metal)/semiconductor Hybrid Nanostmentioning

confidence: 99%

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Metal/Semiconductor Hybrid Nanostructures for Plasmon‐Enhanced Applications

et al. 2014

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Hybrid nanostructures composed of semiconductor and plasmonic metal components are receiving extensive attention. They display extraordinary optical characteristics that are derived from the simultaneous existence and close conjunction of localized surface plasmon resonance and semiconduction, as well as the synergistic interactions between the two components. They have been widely studied for photocatalysis, plasmon-enhanced spectroscopy, biotechnology, and solar cells. In this review, the developments in the field of (plasmonic metal)/semiconductor hybrid nanostructures are comprehensively described. The preparation of the hybrid nanostructures is first presented according to the semiconductor type, as well as the nanostructure morphology. The plasmonic properties and the enabled applications of the hybrid nanostructures are then elucidated. Lastly, possible future research in this burgeoning field is discussed.

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“…[18][19][20] To the best of our knowledge, there have been no reports of the MR imaging of a human prostate tumor model using such core-shells. In this work, we developed a method to prepare uniform SPION@Au core-shells via an intermediate layer between the core and shell that strongly bonds these two layers and prevents the di®usion of gold atoms into the SPION, thereby protecting its magnetization vector.…”

Section: Introductionmentioning

confidence: 99%

Development of Gold-Coated Magnetic Nanoparticles as a Potential MRI Contrast Agent

Montazerabadi

Oghabian

Irajirad

et al. 2015

NANO

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Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methylpolyethylene glycol (mPEG) are synthesized and investigated as a magnetic resonance (MR) imaging contrast agent. The synthesized mPEG-core@shells are characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometry (VSM), zeta-potential analysis and X-ray di®raction (XRD). In addition, the transverse relaxivity of the mPEG-core@shells is measured using a 3 T MRI scanner. The cytotoxicity of the mPEG-core@shells is tested in the LNCaP cell line using an 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that the mPEG-core@shell particles are semispherical with hydrodynamic size of $ 65 nm and a transverse relaxivity of 162.3 mM À1 S À1 . The mPEG-core@shell particles demonstrate good stability in biological media without any signi¯cant in vitro cytotoxicity under high cellular uptake conditions. Finally, in vivo imaging shows that mPEG-core@shells are a potential contrast agent for use in early-stage detection.

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Au-ultrathin functionalized core–shell (Fe3O4@Au) monodispersed nanocubes for a combination of magnetic/plasmonic photothermal cancer cell killing

Cited by 50 publications

References 33 publications

Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes In Situ

Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes In Situ

Metal/Semiconductor Hybrid Nanostructures for Plasmon‐Enhanced Applications

Development of Gold-Coated Magnetic Nanoparticles as a Potential MRI Contrast Agent

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