Auditory event-related potentials at preschool age in children born very preterm

Abstract

Auditory event-related potentials at preschool age in children born very preterm.Hövel, Holger; Partanen, Eino; Huotilainen, Minna; Lindgren, Magnus; Rosén, Ingmar; Fellman, Vineta Link to publication Citation for published version (APA): Hövel, H., Partanen, E., Huotilainen, M., Lindgren, M., Rosén, I., & Fellman, V. (2014). Auditory event-related potentials at preschool age in children born very preterm. Clinical Neurophysiology, 125(3), 449-456. DOI: 10.1016449-456. DOI: 10. /j.clinph.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Highlights• In auditory event-related potentials of preschool children, we found a faster decrease in latencies of P1 and N2 around the age of 5 years than previously described.• At preschool age, children born very preterm had obligatory responses that differed from term-born and late preterm-born children.• The decrease of N1 amplitude in the very preterm born children might reflect cognition, since similar amplitude findings have been described in term-born children with cognitive deficits. 3 AbstractObjective: To assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4±1.9 gestational weeks, n=70) with a high risk of cognitive dysfunction. Methods:We used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or duration). Results:The P1 and N2 latencies were inversely correlated to age (50-63 months) both in VP Conclusions: Our data suggest a fast maturation of P1 and N2 responses with fast decrease in P1 and N2 latencies around the age of 5 years. Mismatch negativity response does not seem to be a robust measure for defining abnormalities in VP children. Significance:In ERP studies in preschool children, even small, non-significant group differences in age at recording should be corrected for. Very preterm born children at preschool age have aERP patterns as earlier described in full-term born children with cognitive deficits. 4

Auditory event-related potentials are related to cognition at preschool age after very preterm birth

“…Lower P1 amplitudes in children born VP have been described earlier (2,16). In this study, the P1 amplitude tended to increase with increasing gestational age, but it was not influenced by brain damage or other morbidity.…”

“…As we in an earlier study had found a significant association between age at examination and AERP latencies (16), and as head size may have an impact on AERP measures, all AERP measures correlating with these factors (P < 0.1 on Pearson bivariate correlations) were corrected for respective factor. Thus, we corrected for head circumference in the time windows between 150-250 and 350-400 ms for the frequency deviant, between 350-400 ms for the direction deviant, and between 200-250 and 350-450 ms for the duration deviant.…”

“…As AERP components show a strong correlation with age at examination (16), all statistics including AERP data were corrected for age. Age at examination correlated significantly with the P1 latency (r = −0.423; P < 0.001), but not with any other AERP data.…”

“…In preterm infants with birth weights below 1,500 g, AERP development during the first year of life differed from healthy term infants (15). Smaller P1 and larger N2 amplitudes were found in Articles 5-y-old children born with mean gestational ages below 28 GW (2,16). In children born at less than 32 GW studied at 2 y of age, MMN responses reflected abnormal phoneme discrimination, which was related to a slower native language acquisition (17).…”

Association of Preterm Birth With Attention-Deficit/Hyperactivity Disorder–Like and Wider-Ranging Neurophysiological Impairments of Attention and Inhibition

“…The ERP studies that have been conducted in preterm-born children have focused mainly on auditory ERP components 24–26. Auditory ERP components are neurophysiological correlates of cortical sound processing and sound discrimination: they are generated involuntarily by the brain during basic auditory encoding (indexed by the ERP component P1) or as a response to a perceived change in continuously repeated sounds (indexed by the ERP components N2, mismatch negativity [MMN] and P3a) 16.…”