Augmentation Index Immediately after Maximal Exercise in Patients with Type 2 Diabetes Mellitus

Sacre, Julian W.; Holland, David J.; Jenkins, Carly; Sharman, James E.

doi:10.1249/mss.0b013e318228588c

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…Arterial biomarkers are usually evaluated at rest. However, responses to exercise can reveal physiologic anomalies that are not observable at rest, including vascular alterations 21 , 22 . Furthermore, the integration of cardiac and arterial analyses in exercise can help in understanding the physiologic and pathophysiologic mechanisms of cardiovascular adaptation to exercise.…”

Section: Discussionmentioning

confidence: 99%

Carotid‐Ventricular Coupling During Exercise

Bianchini

Bruno

Pitino

et al. 2016

J of Ultrasound Medicine

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Section: Discussionmentioning

confidence: 99%

Carotid‐Ventricular Coupling During Exercise

Bianchini

Bruno

Pitino

et al. 2016

J of Ultrasound Medicine

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“…Indeed, we have shown that independent of resting BP, light-moderate exercise hemodynamics can unveil BP abnormalities [16,17] and also predict kidney function in older men [18]. We have also found that patients with T2DM have abnormal responses at higher exercise intensities [19,20]. This study aimed to determine associations between central hemodynamics, including aortic reservoir characteristics, and brain structure in people with and without T2DM, during rest and light-moderate exercise.…”

Section: Introductionmentioning

confidence: 99%

Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study

Climie

Srikanth

Beare

et al. 2014

Cardiovasc Diabetol

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BackgroundCentral hemodynamics help to maintain appropriate cerebral and other end-organ perfusion, and may be altered with ageing and type 2 diabetes mellitus (T2DM). We aimed to determine the associations between central hemodynamics and brain structure at rest and during exercise in people with and without T2DM.MethodsIn a sample of people with T2DM and healthy controls, resting and exercise measures of aortic reservoir characteristics (including excess pressure integral [Pexcess]) and other central hemodynamics (including augmentation index [AIx] and aortic pulse wave velocity [aPWV]) were recorded. Brain volumes (including gray matter volume [GMV] and white matter lesions [WML]) were derived from magnetic resonance imaging (MRI) scans. Multivariable linear regression was used to study the associations of hemodynamic variables with brain structure in the two groups adjusting for age, sex, daytime systolic BP (SBP) and heart rate.ResultsThere were 37 T2DM (63 ± 9 years; 47% male) and 37 healthy individuals (52 ± 8 years; 51% male). In T2DM, resting aPWV was inversely associated with GMV (standardized β = −0.47, p = 0.036). In healthy participants, resting Pexcess was inversely associated with GMV (β = −0.23, p = 0.043) and AIx was associated with WML volume (β = 0.52, p = 0.021). There were no associations between exercise hemodynamics and brain volumes in either group.ConclusionsBrain atrophy is associated with resting aortic stiffness in T2DM, and resting Pexcess in healthy individuals. Central vascular mechanisms underlying structural brain changes may differ between healthy individuals and T2DM.

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“…Arterial stiffness may play a key role in the occurrence of CV events in patients with T2DM whose HGS is low as we previously reported 9 . Acute handgrip exercises increase AIx and cSBP which is more strongly related to CV than brachial blood pressure in healthy individuals 28 , while AIx decreases after maximal exercise in T2DM patients who usually have impaired cardiac function 29 . The effect of acute exercise on arterial stiffness is different between healthy individuals and patients with T2DM 30 ; therefore, we should also be careful to interpret the association between HGS and AIx in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Handgrip strength is inversely associated with augmentation index in patients with type 2 diabetes

Hamasaki¹,

Yanai

2023

Sci Rep

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Handgrip strength (HGS) is a measure of overall skeletal muscle strength and is used to identify risks for cardiovascular disease and mortality. Furthermore, HGS is an indicator of arterial stiffness that leads to atherosclerotic cardiovascular disease. This study aimed to examine the relationship between HGS and augmentation index (AIx) in patients with type 2 diabetes. A cross-sectional study was conducted to examine patients with type 2 diabetes whose HGS and AIx were measured in our hospital. AIx was measured noninvasively using an applanation tonometer, and multiple regression analyses were conducted to assess the independent relationship between HGS and AIx. This study included 404 patients. After adjusting for age, gender, body mass index, duration of diabetes, smoking and exercise habit, biochemical parameters, and physiological parameters related to arterial stiffness, HGS was found to be independently and inversely associated with AIx (β = − 0.270, p = 0.006). HGS was independently and inversely associated with AIx in patients with type 2 diabetes. Patients with diminished HGS should be subjected to intensive exercise therapy for reducing the risk of arterial stiffness and cardiovascular disease.Trial registration: UMIN000023010.

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Augmentation Index Immediately after Maximal Exercise in Patients with Type 2 Diabetes Mellitus

Abstract: Patients with T2DM have significantly (and paradoxically) lower postexercise central AIx and greater central AIx reserve, which may be explained by an impaired cardiac functional reserve.

Cited by 10 publications

References 36 publications

Carotid‐Ventricular Coupling During Exercise

Carotid‐Ventricular Coupling During Exercise

Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study

Handgrip strength is inversely associated with augmentation index in patients with type 2 diabetes

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