Augmentation of Intraorbital Volume with Fat Injection

Brown, Matthew S.; Lee, Michelle; Zwiebel, Samantha; Adenuga, Paul; Molavi, Sima; Gargesha, Madhusudhana; Varghai, Davood; Guyuron, Bahman

doi:10.1097/prs.0000000000000105

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…In this regard a study on experimental, orbital volume augmentation in rabbits with injection of hyaluronic acid and human, xenogenic ADRCs resulted in lasting inflammation for at least 6 weeks posttreatment followed by formation of profound fibrosis/scar tissue [80], which may have also occurred in [77][78][79]. However, formation of profound fibrosis/scar tissue (most probably secondary to a chronic inflammatory (rejection) reaction caused by application of xenogenic ADRCs) is neither the aim in orbital volume augmentation [81] nor the aim in tendon regeneration. Considering these data and substantial ethical concerns in potential application of allogeneic ADRCs in treatments of human tendon pathologies this approach appears not suitable for clinical routine use.…”

Section: Discussionmentioning

confidence: 99%

New, biomechanically sound tendon tissue after injection of uncultured, autologous, adipose derived regenerative cells in partial Achilles tendon defects in rabbits

Schmitz,

Alt,

Würfel

et al. 2024

Preprint

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BackgroundCurrent management options for partial tendon tears may not offer future potential to heal tissue and improve clinical results. This study tested the hypothesis that treatment of a partial rabbit common calcaneus tendon (CCT) defect with uncultured, autologous, adipose derived regenerative cells (UA-ADRCs) enables regenerative healing without scar formation, as recently observed in a biopsy of a human supraspinatus tendon.MethodsA full-thickness hole (diameter, 3 mm) was punched into the midsubstance of the right gastrocnemius tendon (GT; which is a part of the CCT) of adult, female New Zealand white rabbits. Immediately thereafter the rabbits were treated by application of an averaged 28.3×106UA-ADRCs in 0.5 ml lactated Ringer’s solution (RLS) into the GT defect and surrounding tendon tissue, or underwent sham treatment. Rabbits were sacrificed either four weeks (W4) or twelve weeks (W12) post-treatment, and the CCTs were investigated using histology, immunohistochemistry and non-destructive biomechanical testing.ResultsNewly formed connective tissue was consistent with the formation of new tendon tissue after treatment with UA-ADRCs, and with the formation of scar tissue after sham treatment, at both W4 and W12 post-treatment. Biomechanical testing demonstrated a significantly higher mean percent relaxation after treatment with UA-ADRCs than after sham treatment (p < 0.05), and significant, negative correlations between the peak stress as well as the equilibrium stress and the cross-sectional area of the CCT (p < 0.05) after treatment with UA-ADRCs but not after sham treatment.ConclusionsManagement of partial tendon tears with UA-ADRCs has the potential to be truly “structure-modifying”.

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Section: Discussionmentioning

confidence: 99%

New, biomechanically sound tendon tissue after injection of uncultured, autologous, adipose derived regenerative cells in partial Achilles tendon defects in rabbits

Schmitz,

Alt,

Würfel

et al. 2024

Preprint

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“…In an animal experiment, 24 the right eye orbital volume of 10 rabbits was augmented with autologous fat injected into the retrobulbar space. Right globe position showed a mean increase in eye proptosis of 3.4 mm at postoperative day 1 and of 0.9 mm at 11 weeks postoperatively in comparison with the left globe position.…”

Section: Discussionmentioning

confidence: 99%

Widening Aging Eyes and Ending Outdoor Tearing with Retrobulbar Injections of Dermal Fillers

Lemperle¹,

Kassem-Trautmann²,

Schmidt

2023

Plastic and Reconstructive Surgery - Global Open

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Background: As people age, the intraorbital fat may diminish and palpebral fissures may narrow, causing the eyes to increasingly tear outside in cold weather. As the bulbus recedes from the conjunctiva, a “wind trap” is formed in the lateral corner of the eye. This wind trap appears to irritate the adjacent lacrimal gland. In this article, an 84-year-old patient experienced annoying outdoor tearing despite having undergone three tarsal strip canthopexies during the past 20 years. Methods: Retrobulbar injections of 3.5-mL high-viscous dermal fillers (Bellafill or Radiesse) pushed the eyeballs forward, aligned the bulbus with the conjunctiva, and closed the wind trap behind the lateral canthus. Magnetic resonance imaging confirmed the filler material in the posterior lateral corner of the orbit. Results: The effect was immediate: the patient’s constant outdoor tearing had resolved after the first treatment of his senile enophthalmos. In addition, the narrow palpebral fissure had widened by 2 mm and rejuvenated his aging eyes. Conclusions: An eyeball that has receded with age can be pushed forward with a retrobulbar injection of a long lasting dermal filler to reattach to the eyelids.

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In Vitro Modeling of Co-Transplantation of Multipotent Stromal Mesenchymal Cells from Orbital Fat Pad and Lipoaspirate of Human Subcutaneous Adipose Tissue in Organ Culture in Collagen Gel

et al. 2018

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The interplay of multipotent stromal cells derived from the orbital fat pads and cells of the lipoaspirate from the subcutaneous adipose tissue was studied using in vitro co-transplantation model in an organ culture in a collagen gel. Microscopy findings and intensity of apoptosis and cell proliferation in cultures of lipoaspirate with and without multipotent stromal cells showed that the cells maintained their viability, proliferation capacity, and cytokine secretion activity. Higher proliferatitive activity of cells in cocultures promotes renewal of fat transplant cells and can help to maintain its stable volume in delayed terms after transplantation.

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Augmentation of Intraorbital Volume with Fat Injection

Abstract: Fat injection can augment orbital volume in an animal model and preserve visual function. Further investigation is necessary to document the clinical safety and value of this technique in humans.

Cited by 8 publications

References 26 publications

New, biomechanically sound tendon tissue after injection of uncultured, autologous, adipose derived regenerative cells in partial Achilles tendon defects in rabbits

New, biomechanically sound tendon tissue after injection of uncultured, autologous, adipose derived regenerative cells in partial Achilles tendon defects in rabbits

Widening Aging Eyes and Ending Outdoor Tearing with Retrobulbar Injections of Dermal Fillers

In Vitro Modeling of Co-Transplantation of Multipotent Stromal Mesenchymal Cells from Orbital Fat Pad and Lipoaspirate of Human Subcutaneous Adipose Tissue in Organ Culture in Collagen Gel

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