Aujeszky's disease in a pack of hounds

Gore, Robert W.; Osborne, A. D.; Darke, P. G. G.; Todd, J

doi:10.1136/vr.101.5.93

Cited by 19 publications

(25 citation statements)

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“…Some reports described lesions outside the CNS, such as petechiae and ecchymoses, which were widespread in mink, probably caused by mechanisms like shock, diffuse intravascular coagulation or endotheliotropism (KIMMAN and VAN OIRSCHOT, 1986). Inclusion bodies in the myenteric plexus were observed in dogs (GORE et al, 1977). In our cases, disseminated intravascular coagulation was common finding in infected foxes whereas we could not identify either ADV antigen in the endothelial cells o r inclusion bodies outside the CNS.…”

Section: Discussioncontrasting

confidence: 58%

Experimental Aujeszky's Disease in Blue Foxes (Alopex lagopus

Quiroga

Vázquez

López-Peña

et al. 1995

Journal of Veterinary Medicine Series A

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Summary Blue foxes were inoculated orally with Aujeszky's disease virus. Several foxes were killed at the onset of clinical signs and other animals spontaneously died. The incubation period ranged from 3 to 6 days and was followed by a short illness characterized by anorexia, depression and coma. At autopsy, no specific gross findings were observed. Microscopically, lesions included a non‐suppurative meningoencephalitis with neuronal necrosis, gliosis, neuronophagia and mononuclear cell cuffing. Viral antigen was detected by immunoperoxidase technique.

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Section: Discussioncontrasting

confidence: 58%

Experimental Aujeszky's Disease in Blue Foxes (Alopex lagopus

Quiroga

Vázquez

López-Peña

et al. 1995

Journal of Veterinary Medicine Series A

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“…8 Clinical features in the cases in the present study were not like those associated with canine Aujeszky's disease (peracute onset of respiratory and alimentary clinical signs or intense pruritus), and histopathologic features of neuronal degeneration, ganglionitis, and the presence of inclusion bodies were not observed. Antibody titers were not observed in the two animals that were tested.…”

Section: Discussioncontrasting

confidence: 54%

“…8 Because of the association of the dams of the affected animals with Texas (USA), additional encephalitogenic rickettsial agents endemic in the southwestern USA (R. rickettsii and E. Meningoencephalitis in Greyhounds canis) were included in the differential diagnosis. 9,26 Although reports of neurologic disease associated with B. burgdorferi infection are rare, this agent has been identified within ticks in Ireland and is associated with encephalitis in humans and animals.…”

Section: Discussionmentioning

confidence: 99%

A Novel Nonsuppurative Meningoencephalitis in Young Greyhounds in Ireland

et al. 2002

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Fourteen 4- to 18-month-old vaccinated Greyhounds (10 males, 4 females) from three kennels in southern Ireland presented over a 2-year period with acute or insidious onset neurological signs. Head tilting, ataxia, recumbency, circling, and blindness were commonly observed, and animals were dull, dehydrated, and had lost weight. Hematologic and biochemical parameters reflected dehydration but were otherwise unremarkable. Microscopic examination revealed severe diffuse and focal gliosis and gemistocytosis accompanied by mononuclear cell perivascular cuffing in caudate nucleus and cortical gray matter of the cerebrum and in the periventricular gray matter of the anterior brainstem. Milder lesions were noted in the caudal brainstem, cranial spinal cord, and in the molecular layer of the cerebellum. This was accompanied by a lymphocyte and plasma cell infiltration of the cerebral and cerebellar meninges. Demyelination, neuropil necrosis, neuronophagia, and vasculitis were not observed. No inclusion bodies, fungi, or protozoal cysts were seen. Additional serologic and molecular pathology tests also failed to determine a cause, suggesting that these cases may represent a previously undiagnosed condition in the dog.

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“…lethargy @OW and MCFERRAN, 1963;GORE et al, 1977;PENSAERT et al, 1980;SHELL and GRANDELL, 1981). Several other neurological diseases such as rabies, distemper or insecticide/herbicide toxicosis may develop the same group of signs and thus laboratory methods are required to confirm the diagnosis (HAWKINS and OLSON, 1985).…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Aujeszky's Disease Virus Infection in Dogs by Use of Immunohistochemistry andIn‐SituHybridization

Quiroga

Nieto

Sur

et al. 1998

Journal of Veterinary Medicine Series A

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Aujeszky's disease (AD) was diagnosed in seven dogs by histolog~cal examination, immunohistochemistry and DNA in-situ hybridization. All dogs which lived on two swine farms died spontaneously showing an acute neurological syndrome (hypersalivation, vomiting, pruritus, depression and coma). The most significant histopathological lesion was a non-suppurative encephahtis located in the brain stem, mainly near the floor of the IVth ventricle. Aujeszky's disease virus (ADV) antigen and ADV nucleic acid hstribution coincided with the histopathologcal lesions. However, little ADV antigen and ADV nucleic acid was found in severely damaged areas. A few neurons stained intensely by immunohistochemistry and in-situ hybridization in non-inflamatory areas. Both immunohistochemistry and in-situ hybridization techniques are valid techniques to confirm ADV infection in paraffin-embedded tissues and will be useful for characterizing the pathogenesis of ADV in the central nervous system (CNS) in carnivores.

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Aujeszky's disease in a pack of hounds

Cited by 19 publications

References 0 publications

Experimental Aujeszky's Disease in Blue Foxes (Alopex lagopus

Experimental Aujeszky's Disease in Blue Foxes (Alopex lagopus

A Novel Nonsuppurative Meningoencephalitis in Young Greyhounds in Ireland

Diagnosis of Aujeszky's Disease Virus Infection in Dogs by Use of Immunohistochemistry andIn‐SituHybridization

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