The volume of E-commerce transactions had accelerated on huge scale due to COVID-19. Telemedicine comes under the segment of E-commerce, where the patients can get their treatments from isolates. Patients’ information security is a basic challenge in this COVID-19 telemedicine segment. The majority of the non-obtrusive and non-emergency patients are encouraged and treated distantly from their secludes without the inclusion of COVID-19 transmission. Anxiety, depressive disorders, stress, dementia, mood disorder, OCD, aggression, etc. are the critical mental challenges that have abruptly occurred during this COVID period. The present work focused on “New Normal Mode” of COVID-19 telepsychiatry so that the patients’ mental illness can be treated remotely in a secure way. An episode of dual neural-genetic firefly (DNGF) has been proposed on COVID-19 "New Normal Mode" 2nd wave telepsychiatry. The pool of transmission keys was generated with the help of firefly algorithm, neural perceptron, and genetic operations. Besides these, the proposed DNGF keys are effective to be used for different online psychiatric transactions. The objectivity of this paper is to generate a robust pool of transmission keys in order to nullify different types of intruding. It has effectively cleared Avalanche test and Strict Avalanche test. The outcome of parameterized functional security test has been recorded with adequacy. These were: 0.327933, 0.350467, 0.332533, 0.317867, and 0.350267 on the generated pool of DNGF. The correlation coefficient between the key generation time and parameterized functional security has been found to be
Distinctive mathematical arranged examinations were directed on the proposed key pool. It has shown better reasonability on the part of the COVID-19 2nd wave telepsychiatry, which is a component of E-commerce.