Autoantibodies against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia

Abstract

Objective:Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism’s self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been explained. The aim of this study was to evaluate CA I and II autoantibodies in patients with acute myeloid leukemia (AML) and to provide a novel perspective regarding the autoimmune basis of the disease.Materials and Methods:Anti-CA I and II antibody levels were investigated using ELISA in serum samples from 30 patients with AML and 30 healthy peers.Results:Anti-CA I and II antibody titers in the AML group were significantly higher compared with the control group (p=0.0001 and 0.018, respectively). A strong positive correlation was also determined between titers of anti-CA I and II antibodies (r=0.613, p=0.0001).Conclusion:Our results suggest that these autoantibodies may be involved in the pathogenesis of AML. More extensive studies are now needed to reveal the entire mechanism.

The Human Carbonic Anhydrase II in Platelets: An Underestimated Field of Its Activity

“…Moreover, in 2007, it was presented that also in rheumatoid arthritis there are present aCAAs in serum, showing affinity to bind to carbonic anhydrase III in synovial membranes [ 16 ]. Up to date aCAAs have been described in patients with rheumatoid disorders (rheumatoid arthritis, Behçet's disease, lupus erythematosus, polymyositis, systemic sclerosis, and Sjögren syndrome) [ 16 – 18 ], digestive tract disorders (idiopathic chronic pancreatitis, primary biliary cirrhosis, autoimmune cholangitis, and gastric cancer) [ 18 , 19 ], endometriosis [ 18 ], Grave's disease [ 20 ], acute myeloid leukaemia [ 21 ], renal tubular acidosis [ 22 ] (significant influence on pathogenesis proved in the animal model of Sjögren's syndrome [ 23 ]), and end-stage kidney disease [ 24 ]. Moreover, autoantibodies against carbonic anhydrase II were proved to play an important role in pathogenesis of retinopathy [ 25 ] and these against CAVI seem to induce dry eye syndrome in Sjögren's syndrome [ 26 , 27 ].…”

Association between the expression of carbonic anhydrase�II and clinicopathological features of hepatocellular carcinoma

“…In previous years, HCC and healthy control groups have been analyzed and compared through protein-protein interaction (PPI) analysis, which has identified markers of disease occurrence and development, providing a theoretical basis for the development of targeted drugs (9). Carbonic anhydrases (CAs), a crucial family of 16 isoenzymes, distribute in different tissues (10). Carbonic anhydrase II (CA2), first identified in red blood cells as monomers, have been suggested to be a prognostic factor of several tumor diseases, including pancreatic (11), colorectal (12) and gastric cancer (13), and peritoneal myxoma (14).…”

Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

“…In our study, patients with the factors that affect MDA, SOD, CAT and CRP levels were excluded. These factors; smokers 8,9 , cancer patients 10,11 , the diagnosis of patients with malignant hematological disease 12 and patients who suffered near-term organophosphate were not included in the study 13,14 . This study was planned as three groups (n=50); Group 1: Patients operated for generalized peritonitis in emergency condition.…”